Archive | June, 2005

Dronabinol treatment of delayed chemotherapy-induced nausea and vomiting (CINV).

J Clin Oncol. 2005 Jun;23(16_suppl):8018. Meiri E1, Jhangiani H1, Vredenburgh J1, Barbato L1, Yang H1, Li D1, Baranowski V1, Tse N1. Author information Abstract 8018 Background: Dronabinol (MARINOL), synthetic tetrahydrocannabinol, binds to cannabinoid receptors and has antiemetic activity. To explore if this novel mechanism would be of benefit in delayed CINV, dronabinol was added to the prophylactic regimen for acute CINV and continued […]

Tolerability of dronabinol alone, ondansetron alone and the combination of dronabinol plus ondansetron in delayed chemotherapy-induced nausea and vomiting.

J Clin Oncol. 2005 Jun;23(16_suppl):8196. Jhangiani H1, Meiri E1, Vredenburgh J1, Barbato L1, Yang H1, Li D1, Baranowski V1, Tse N1. Author information Abstract 8196 Background: Dronabinol (Marinol), the synthetic version of tetrahydrocannabinol, is used to treat nausea and vomiting following cancer chemotherapy (CINV). It has a unique mechanism of action (cannabinoid receptor binding) compared to the more frequently used serotonin receptor antagonists. […]

Occurrence and possible biological role of the endocannabinoid system in the sea squirt Ciona intestinalis.

2005 Jun;93(5):1141-56. Occurrence and possible biological role of the endocannabinoid system in the sea squirt Ciona intestinalis. Matias I1, McPartland JM, Di Marzo V. Author information Abstract A cannabinoid receptor orthologue (CiCBR) has been described in the sea squirt Ciona intestinalis. Here we report that CiCBR mRNA expression is highest in cerebral ganglion, branchial pharynx, heart and testis of C. […]