Archive | July, 2006

Plant, synthetic, and endogenous cannabinoids in medicine.

2006;57:553-74. Plant, synthetic, and endogenous cannabinoids in medicine. Di Marzo V1, Petrocellis LD. Author information Abstract Although used for more than 4000 years for recreational and medicinal purposes, Cannabis and its best-known pharmacologically active constituents, the cannabinoids, became a protagonist in medical research only recently. This revival of interest is explained by the finding in the 1990s of the […]

A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells.

Natalya M. Kogan, Cristina Blázquez, Luis Álvarez, Ruth Gallily, Michael Schlesinger, Manuel Guzmán and Raphael Mechoulam +Author Affiliations Department of Medicinal Chemistry and Natural Products (N.M.K., R.M.), Lautenberg Center for Immunology (R.G.) and Department of Experimental Medicine and Cancer Research (M.S.), Medical Faculty, the Hebrew University, Jerusalem, Israel; Department of Biochemistry and Molecular Biology I, School […]

Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.

 2006 Jul 1;66(13):6748-55. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Carracedo A1, Gironella M, Lorente M, Garcia S, Guzmán M, Velasco G, Iovanna JL. Author information Abstract Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore, it is of especial interest to set new strategies aimed at improving the prognostic of this deadly […]

Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes

Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes Arkaitz Carracedo1, Meritxell Gironella2, Mar Lorente1, Stephane Garcia2, Manuel Guzmán1, Guillermo Velasco1, and Juan L. Iovanna2 +Author Affiliations 1Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain and 2U624 Institut National de la Sante et de la Recherche Medicale, […]

Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.

 2006 Jul 1;66(13):6615-21. Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Caffarel MM1, Sarrió D, Palacios J, Guzmán M, Sánchez C. Author information Abstract It has been proposed that cannabinoids are involved in the control of cell fate. Thus, these compounds can modulate proliferation, differentiation, and survival in different manners depending on the cell […]

The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway.

2006 Jul 1;312(11):2121-31. Epub 2006 Apr 19. The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway. Herrera B1, Carracedo A, Diez-Zaera M, Gómez del Pulgar T, Guzmán M, Velasco G. Author information Abstract Delta9-tetrahydrocannabinol and other cannabinoids exert pro-apoptotic actions in tumor cells via the CB2 cannabinoid receptor. However, the molecular mechanism involved in this effect has remained elusive. […]