Archive | September, 2006

Control of Breast Cancer by the Endocannabinoid System

McAllister, Sean D. California Pacific Medical Center Research Institute, San Francisco, CA, United States   Abstract Activation of the endocannabinoid system through CB1, CB2 and additional receptor subtypes results in the inhibition of a broad range of cancers. The endocannabinoid system was discovered through research focusing on the classical cannabinoid agonist, ?9-tetrahydrocannabinol (?9-THC), and other synthetic […]

[Different views on the association between cannabinoids and cancer].

 2006;145(6):453-7; discussion 458-9. [Different views on the association between cannabinoids and cancer]. [Article in Slovak] Vidinský B1, Gál P, Mojzis J. Author information Abstract Cannabinoids are the major active components of the most widely used illegal drug – marihuana. They have a long history of the medicinal use. However, they are still a controversial topic in oncological […]

Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.

 2006 Sep;70(3):897-908. Epub 2006 Jun 5. Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression. McKallip RJ1, Jia W, Schlomer J, Warren JW, Nagarkatti PS, Nagarkatti M. Author information Abstract In the current study, we examined the effects of the nonpsychoactive cannabinoid, cannabidiol, on the induction of apoptosis in leukemia cells. Exposure of leukemia cells to cannabidiol […]

The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells

 2006 Sep;63(17):2057-66. The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Massi P1, Vaccani A, Bianchessi S, Costa B, Macchi P, Parolaro D. Author information Abstract Recently, we have shown that the non-psychoactive cannabinoid compound cannabidiol (CBD) induces apoptosis of glioma cells in vitro and tumorregression in vivo. The present study investigated a possible involvement of caspase activation and reactive oxygen species (ROS) induction in the apoptotic effect of […]

[Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus].

2006 Sep;57(9):801-7. [Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus]. [Article in German] Ständer S1, Reinhardt HW, Luger TA. Author information Abstract BACKGROUND: Chronic, therapy-resistant pruritus often fails to respond to standard measures so new therapeutic approaches are needed. Recently, the expression of cannabinoid receptors on cutaneous sensory nerve fibers was described, so cannabinoid agonists seem a […]