Archive | September, 2007

Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats

Original Article Kidney International (2007) 72, 1345–1357; doi:10.1038/sj.ki.5002540; published online 19 September 2007 Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats P Janiak1, B Poirier1, J-P Bidouard1, C Cadrouvele1, F Pierre1, L Gouraud1, I Barbosa1, J Dedio1, J-P Maffrand1, G Le Fur1, S O’Connor1 and J-M Herbert1 1Cardiovascular Therapeutic Department, Sanofi-Aventis Research & Development, Chilly-Mazarin, France Correspondence: P Janiak, Cardiovascular Therapeutic Department, […]

The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.

2007 Nov 15;121(10):2172-80. The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. Greenhough A1, Patsos HA, Williams AC, Paraskeva C. Author information Abstract Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival […]