Archive | January, 2008

Regulating compassion: an overview of Canada’s federal medical cannabis policy and practice

Harm Reduct J. 2008; 5: 5.  Published online 2008 Jan 28. doi:  10.1186/1477-7517-5-5 PMCID: PMC2267789 Regulating compassion: an overview of Canada’s federal medical cannabis policy and practice Philippe G Lucas1,2,3,4,5 Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Background In response to a number of court challenges brought forth […]

Cannabinoids for cancer treatment: progress and promise.

  2008 Jan 15;68(2):339-42. doi: 10.1158/0008-5472.CAN-07-2785. Cannabinoids for cancer treatment: progress and promise. Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, Farrukh Afaq, and Hasan Mukhtar +Author Affiliations Chemoprevention Program, Paul P. Carbone Comprehensive Cancer Center and Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin Requests for reprints: Hasan […]

Cannabinoids as potential new therapy for the treatment of gliomas.

2008 Jan;8(1):37-49. Cannabinoids as potential new therapy for the treatment of gliomas. Parolaro D1, Massi P. Author information Abstract Gliomas constitute the most frequent and malignant primary brain tumors. Current standard therapeutic strategies (surgery, radiotherapy and chemotherapeutics, e.g., temozolomide, carmustin or carboplatin) for their treatment are only palliative and survival diagnosis is normally 6-12 months. The […]

Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon

Journal of Molecular Medicine (Berlin, Germany) J Mol Med. 2008 Jan; 86(1): 89–98.  Published online 2007 Sep 6. doi:  10.1007/s00109-007-0248-4 PMCID: PMC2755791 Angelo A. Izzo,1 Gabriella Aviello,1 Stefania Petrosino,2,3 Pierangelo Orlando,4Giovanni Marsicano,5,6,9 Beat Lutz,5,6 Francesca Borrelli,1 Raffaele Capasso,1 Santosh Nigam,7,8 Francesco Capasso,1 Vincenzo Di Marzo,2 and Endocannabinoid Research Group Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Colorectal cancer […]

Targeting Cannabinoid Receptors in Brain Tumors

2008, pp 361-374 Targeting Cannabinoid Receptors in Brain Tumors Guillermo Velasco, Arkaitz Carracedo, Cristina Blázquez, Mar Lorente, Tania Aguado, Cristina Sánchez, Ismael Galve-Roperh, Manuel Guzmán  Get Access Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances — the endocannabinoids — that activate specific cell surface receptors. Cannabinoids exert various palliative effects […]

Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?

 2008 Jan;54(1):235-43. Epub 2007 Jul 1. Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Blázquez C1, Carracedo A, Salazar M, Lorente M, Egia A, González-Feria L, Haro A, Velasco G, Guzmán M. Author information Abstract Cannabinoids, the active components of Cannabis sativa L. and their derivatives, inhibit tumor growth in laboratory animals by inducing apoptosis of […]

Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines.

2008 Jan;43(1):66-72. Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines. Notarnicola M1, Messa C, Orlando A, Bifulco M, Laezza C, Gazzerro P, Caruso MG. Author information Abstract OBJECTIVE: Cannabinoids are a class of compounds that have the ability to activate two specific receptor subtypes, the cannabinoid CB1 and CB2 receptors. CB1 receptor is a G-protein-coupled receptor that is linked to the signal transduction pathways. The cumulative effects of this receptor have important implications in […]