Archive | May, 2008

Cannabinoid receptors: where they are and what they do.

2008 May;20 Suppl 1:10-4. doi: 10.1111/j.1365-2826.2008.01671.x. Cannabinoid receptors: where they are and what they do. Mackie K1. Author information Abstract The endocannabinoid system consists of the endogenous cannabinoids (endocannabinoids), cannabinoid receptors and the enzymes that synthesise and degrade endocannabinoids. Many of the effects of cannabinoids and endocannabinoids are mediated by two G protein-coupled receptors (GPCRs), […]

A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells.

2008 May;8(5):732-40. doi: 10.1016/j.intimp.2008.01.018. Epub 2008 Feb 14. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Lee CY1, Wey SP, Liao MH, Hsu WL, Wu HY, Jan TR. Author information Abstract It has been shown that leukemia and glioma cells are sensitive to cannabidiol (CBD)-induced apoptosis, whereas primary monocytes and glia cells are relatively insensitive. […]

The role of the endocannabinoid system in atherosclerosis.

2008 May;20 Suppl 1:53-7. doi: 10.1111/j.1365-2826.2008.01685.x. The role of the endocannabinoid system in atherosclerosis. Mach F1, Steffens S. Author information Abstract Our current understanding of the pathophysiology of atherosclerosis suggests a prominent role for immune responses from its initiation through its complications. Given the increasing prevalence of cardiovascular risk factors worldwide, there is an urgent need to better understand […]

JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells.

 2008 Aug 28;27(37):5033-44. doi: 10.1038/onc.2008.145. Epub 2008 May 5. JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Caffarel MM1, Moreno-Bueno G, Cerutti C, Palacios J, Guzman M, Mechta-Grigoriou F, Sanchez C. Author information Abstract It has been recently shown that cannabinoids, the active components of marijuana and their derivatives, inhibit cell cycle progression of human […]