Archive | November, 2008

The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation.

2008 Nov-Dec;28(6A):3743-8. The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation. Lissoni P1, Tintori A, Fumagalli L, Brivio F, Messina G, Parolini D, Biondi A, Balestra A, D’Amico G. Author information Abstract BACKGROUND: The cannabinoids have been proposed in the treatment of cancer. Generally, the cannabinoids are believed to be useful only in the palliative therapy of cancer-related symptoms, namely pain, anorexia […]

Activation of CB2 cannabinoid receptors: a novel therapeutic strategy to accelerate osseointegration of dental implants.

 2009 Mar;72(3):311-3. doi: 10.1016/j.mehy.2008.09.047. Epub 2008 Nov 21. Activation of CB2 cannabinoid receptors: a novel therapeutic strategy to accelerate osseointegration of dental implants. Qian H1, Jin Z, Li S, Huo N, Han C, Sang H. Author information Abstract Dental implants have been widely inserted in jaw bones as substitutes for teeth to restore oral function over the last few decades, […]

‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors

Br J Pharmacol. Nov 2008; 155(6): 837–846. Published online Aug 11, 2008. doi:  10.1038/bjp.2008.324 PMCID: PMC2597234 ‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors W-SV Ho,1,* D A Barrett,2 and M D Randall1 Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Background and purpose: The endocannabinoid N-arachidonoylethanolamide (anandamide) is co-synthesized with […]

Phytochemical and genetic analyses of ancient cannabis from Central Asia

J Exp Bot. 2008 November; 59(15): 4171–4182. doi:  10.1093/jxb/ern260 PMCID: PMC2639026 Phytochemical and genetic analyses of ancient cannabis from Central Asia Ethan B. Russo,1,2,3,* Hong-En Jiang,4,5 Xiao Li,5 Alan Sutton,2 Andrea Carboni,6 Francesca del Bianco,6 Giuseppe Mandolino,6 David J. Potter,2 You-Xing Zhao,7 Subir Bera,8 Yong-Bing Zhang,5 En-Guo Lü,9 David K. Ferguson,10 Francis Hueber,11 Liang-Cheng Zhao,12 Chang-Jiang Liu,4 Yu-Fei Wang,4 and Cheng-Sen Li5,13,* Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go […]

Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death.

2007 Dec 7;364(1):131-7. Epub 2007 Oct 2. Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Athanasiou A1, Clarke AB, Turner AE, Kumaran NM, Vakilpour S, Smith PA, Bagiokou D, Bradshaw TD, Westwell AD, Fang L, Lobo DN, Constantinescu CS, Calabrese V, Loesch A, Alexander SP, Clothier RH, Kendall DA, Bates TE. Author information Abstract Time-lapse microscopy of human lung cancer (H460) cells showed that the endogenous cannabinoid […]

High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells.

 2008 Nov 1;86(14):3212-20. doi: 10.1002/jnr.21757. High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. Widmer M1, Hanemann CO, Zajicek J. Author information Abstract Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Gliomacells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be induced by cannabinoids in these cells. Whether this also […]

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

Published in Volume 115, Issue 11 (November 1, 2005) J Clin Invest. 2005;115(11):3104–3116. doi:10.1172/JCI25509. Copyright © 2005, American Society for Clinical Investigation Research Article Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects Wen Jiang1,2, Yun Zhang1, Lan Xiao1,Jamie Van Cleemput1, Shao-Ping Ji1, Guang Bai3 andXia Zhang1 1Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. […]