Archive | May, 2010

The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration.

2010 May;28(4):357-63. doi: 10.3109/07357900903405934. The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Leelawat S1, Leelawat K, Narong S, Matangkasombut O. Author information Abstract Currently, only gemcitabine plus platinum demonstrates the considerable activity for cholangiocarcinoma. The anticancer effect of Delta (9)-tetrahydrocannabinol (THC), the principal active component of cannabinoids […]

Cannabidiol hydroxyquinone-induced apoptosis of splenocytes is mediated predominantly by thiol depletion.

2010 May 19;195(1):68-74. doi: 10.1016/j.toxlet.2010.02.012. Epub 2010 Feb 23. Cannabidiol hydroxyquinone-induced apoptosis of splenocytes is mediated predominantly by thiol depletion. Wu HY1, Jan TR. Author information  Abstract Cannabidiol, the major nonpsychotropic phytocannabinoid, has been recently demonstrated to induce apoptosis in primary lymphocytes via an oxidative stress-dependent mechanism. Cannabidiol can be converted by microsomal enzymes to the hydroxyquinone […]

Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells.

2010 May 15;110(2):321-32. doi: 10.1002/jcb.22540. Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells. Xian XS1, Park H, Cho YK, Lee IS, Kim SW, Choi MG, Chung IS, Han KH, Park JM. Author information Abstract Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the […]