Archive | March, 2011

Role of cannabinoids in multiple sclerosis

2011 Mar;25(3):187-201. doi: 10.2165/11539000-000000000-00000. Role of cannabinoids in multiple sclerosis. Zajicek JP, Apostu VI. Author information Abstract Although extracts from the cannabis plant have been used medicinally for thousands of years, it is only within the last 2 decades that our understanding of cannabinoid physiology and the provision of evidence for therapeutic benefit of cannabinoids has begun to […]

Update on the endocannabinoid system as an anticancer target.

 2011 Mar;15(3):297-308. doi: 10.1517/14728222.2011.553606. Epub 2011 Jan 19. Malfitano AM1, Ciaglia E, Gangemi G, Gazzerro P, Laezza C, Bifulco M. Author information Abstract INTRODUCTION: Recent studies have shown that the endocannabinoid system (ECS) could offer an attractive antitumor target. Numerous findings suggest the involvement of this system (constituted mainly by cannabinoid receptors, endogenous compounds and the enzymes for their synthesis […]

Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS

Curr Neuropharmacol. 2011 March; 9(1): 205–208. doi:  10.2174/157015911795017416 PMCID: PMC3137183 Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS E.S Onaivi* Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Cannabinoids are the constituents of the marijuana plant (Cannabis sativa). There are numerous cannabinoids and other natural compounds that have been […]

Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by molecular dynamics simulation

2011 Mar 7;13(9):3660-8. doi: 10.1039/c0cp01456g. Epub 2010 Dec 21. Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by moleculardynamics simulation. Ramos J1, Cruz VL, Martínez-Salazar J, Campillo NE, Páez JA. Author information  Abstract Cannabinoid receptors CB1 and CB2 are a striking class of transmembrane proteins involved in a high number of important biological processes. In spite of the inherent similarity (40% in aminoacid sequence) these receptors are found in different cell environments. […]