Archive | September, 2011

Allosteric modulation of glycine receptors

Br J Pharmacol. 2011 September; 164(2): 224–236. doi:  10.1111/j.1476-5381.2011.01471.x PMCID: PMC3174402 Allosteric modulation of glycine receptors Gonzalo E Yevenes1 and Hanns Ulrich Zeilhofer1,2 Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Inhibitory (or strychnine sensitive) glycine receptors (GlyRs) are anion-selective transmitter-gated ion channels of the cys-loop superfamily, which includes among others also […]

Discovery of Potent Dual PPARα Agonists/CB1 Ligands.

2011 Sep 16;2(11):793-7. doi: 10.1021/ml200091q. eCollection 2011. Discovery of Potent Dual PPARα Agonists/CB1 Ligands. Pérez-Fernández R1, Fresno N1, Macías-González M2, Elguero J1, Decara J3, Girón R4, Rodríguez-Álvarez A4, Martín MI4, Rodríguez de Fonseca F3, Goya P1. Author information Abstract This letter describes the synthesis and in vitro and in vivo evaluation of dual ligands targeting the cannabinoid and peroxisome proliferator-activated receptors (PPAR). These compounds were obtained […]

Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease.

2011 Sep;89(9):1509-18. doi: 10.1002/jnr.22682. Epub 2011 Jun 14. Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease. Sagredo O1, Pazos MR, Satta V, Ramos JA, Pertwee RG, Fernández-Ruiz J. Author information  Abstract We studied whether combinations of botanical extracts enriched in either Δ(9)-tetrahydrocannabinol (Δ(9)-THC) or cannabidiol (CBD), which are the main constituents of the cannabis-based medicine Sativex, provide neuroprotection in rat […]

Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).

ACS Journals  Bioactive Prenylogous Cannabinoid from Fiber Hemp (Cannabis sativa) Federica Pollastro †, Orazio Taglialatela-Scafati ‡,Marco Allarà §, Eduardo Muñoz , Vincenzo Di Marzo §, Luciano De Petrocellis *§, and Giovani Appendino *† Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Via Bovio 6, 28100, Novara, Italy Dipartimento di Chimica delle Sostanze Naturali,Università di Napoli Federico II, Via Montesano 49, 80131 Napoli, Italy Endocannabinoid […]

Increased Expression of Cannabinoid CB1 Receptors in Achilles Tendinosis

  Increased Expression of Cannabinoid CB1 Receptors in Achilles Tendinosis Emmelie Björklund mail, Sture Forsgren, Håkan Alfredson, Christopher J. Fowler Published: September 08, 2011 DOI: 10.1371/journal.pone.0024731 Abstract Background The endogenous cannabinoid system is involved in the control of pain. However, little is known as to the integrity of the cannabinoid system in human pain syndromes. Here we […]

Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum.

2011 Sep 17;2(11):866-9. doi: 10.1021/ml200183z. eCollection 2011. Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum. Elsebai MF1, Rempel V2, Schnakenburg G3, Kehraus S4, Müller CE2, König GM4. Author information Abstract The fungus Auxarthron reticulatum derived from the marine sponge Ircinia variabilis produced the diketopiperazine alkaloid amauromine (1) and the quinolinone methyl-penicinoline (2). Compound 2 is identical to […]