Archive | April, 2012

Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells.

2012;31(4):377-87. Role of cannabinoid and vanilloid receptors in invasion  of human breast carcinoma cells. Farsandaj N1, Ghahremani MH, Ostad SN. Author information Abstract It is known that the diversified effects of cannabinoid on the fate of carcinoma cells are mediated predominantly through receptors. However, little is known about the effects of the individual activities of cannabinoid and noncannabinoid receptors. Here we investigate the role of cannabinoid receptor (CB) 1, CB2, and transient receptor potential vanilloid type 1 in cell proliferation and invasion patterns in the […]

The biology that underpins the therapeutic potential of cannabis-based medicines for the control of spasticity in multiple sclerosis.

2012 Apr;1(2):64-75. doi: 10.1016/j.msard.2011.11.001. Epub 2012 Jan 18. Baker D1, Pryce G2, Jackson SJ2, Bolton C2, Giovannoni G2. Author information Abstract Cannabis-based medicines have recently been approved for the treatment of pain and spasticity in multiple sclerosis (MS). This supports the original perceptions of people with MS, who were using illegal street cannabis for symptom control and pre-clinical testing […]

Cannabinoids: novel therapies for arthritis?

2012 Apr;4(6):713-25. doi: 10.4155/fmc.12.20. Cannabinoids: novel therapies for arthritis? Dunn SL1, Wilkinson JM, Crawford A, Le Maitre CL, Bunning RA. Author information Abstract A key feature of osteoarthritis and rheumatoid arthritis is the loss of articular cartilage. Cartilage breakdown is mediated by complex interactions of proinflammatory cytokines, such as IL-1, inflammatory mediators, including nitric oxide and prostaglandin E(2), and […]

So what do we call GPR18 now?

Br J Pharmacol. Apr 2012; 165(8): 2411–2413. doi:  10.1111/j.1476-5381.2011.01731.x PMCID: PMC3423231 So what do we call GPR18 now? SPH Alexander Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract The further characterization of the orphan GPCR GPR18 conducted by McHugh et al. in this issue of the British Journal of Pharmacology has generated a […]

Cannabinoids: novel medicines for the treatment of Huntington’s disease.

 2012 Apr 1;7(1):41-8. Cannabinoids: novel medicines for the treatment of Huntington’s disease. Sagredo O, Pazos MR, Valdeolivas S, Fernandez-Ruiz J. Author information Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, 28040-Madrid, Spain. onintza@med.ucm.es Abstract Cannabinoid pharmacology has experienced a notable increase in the last 3 decades which is allowing the development of novel cannabinoid-based medicines for the […]