Archive | February, 2013

Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells.

2013 May;49(8):2066-7. doi: 10.1016/j.ejca.2013.01.026. Epub 2013 Feb 21. Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells. Laezza C, d’Alessandro A, Malfitano AM, Bifulco M. Comment in Modulation of intracellular pathways by anandamide and its evolving role in oncology. [Eur J Cancer. 2013] PMID:  23434151 [PubMed – indexed for MEDLINE] Our studies have demonstrated that […]

Targeting the Endocannabinoid System for Neuroprotection: A 19F-NMR Study of a Selective FAAH Inhibitor Binding with an Anandamide Carrier Protein, HSA.

2013;1(1). pii: 002. Targeting the Endocannabinoid System for Neuroprotection: A 19F-NMR Study of a Selective FAAH Inhibitor Binding with an Anandamide Carrier Protein, HSA. Zhuang J1, Yang DP2, Tian X3, Nikas SP3, Sharma R3, Guo JJ3, Makriyannis A3. Author information Abstract Fatty acid amide hydrolase (FAAH), the enzyme involved in the inactivation of the endocannabinoid anandamide (AEA), is being considered as a therapeutic target for […]

Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma.

 2013 Feb;13(2):237-55. Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma. Esposito E1, Cuzzocrea S. Author information Abstract The endogenous fatty acid palmitoylethanolamide (PEA) is one of the members of N-acyl-ethanolamines family. PEA was identified more than five decades ago and was shown to reduce allergic reactions and inflammation in animals along […]

The neuroprotective effects of cocoa flavanol and its influence on cognitive performance

Br J Clin Pharmacol. Mar 2013; 75(3): 716–727.  Published online Feb 5, 2013. doi:  10.1111/j.1365-2125.2012.04378.x PMCID: PMC3575938 The neuroprotective effects of cocoa flavanol and its influence on cognitive performance Astrid Nehlig Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Cocoa powder and chocolate contain numerous substances among which there […]

Use of cannabis among 139 cluster headache sufferers.

 2013 Feb;33(3):208-13. doi: 10.1177/0333102412468669. Epub 2012 Nov 29. Use of cannabis among 139 cluster headache sufferers. Leroux E1, Taifas I, Valade D, Donnet A, Chagnon M, Ducros A. Author information  Abstract AIMS: A case report suggested the efficacy of cannabis to treat cluster headache (CH) attacks. Our aims were to study the frequency of cannabis use in CH patients, and the reported effects on attacks. METHODS: […]