Archive | May, 2013

Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice.

Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice. Li K, Feng JY, Li YY, Yuece B, Lin XH, Yu LY, Li YN, Feng YJ, Storr M. Source Institute of Digestive Disease, Department of Pathophysiology, Tongji University School of Medicine, Shanghai, China. Abstract OBJECTIVES: The anti-inflammatory effects of O-1602 and cannabidiol (CBD), the ligands of G protein-coupled receptor 55 (GPR55), […]

Cannabis News: The Cannabinoid System Reverses Dementia, Treats PTSD and Controls Diabetes Top May’s News Digest from Publius

  Cannabis News: The Cannabinoid System Reverses Dementia, Treats PTSD and Controls Diabetes Top May’s News Digest from Publius   The Cannabinoid System’s role in reversing dementia, treating PTSD and controlling diabetes highlight May’s cannabis news from Publius, the pen name used by the authors of The Cannabis Papers – Federal ignorance goes on unabated. […]

Δ9-Tetrahydrocannabinol Disrupts Estrogen-Signaling Through Up-regulation of Estrogen Receptor β (ERβ).

. [Epub ahead of print] Δ9-Tetrahydrocannabinol Disrupts Estrogen-Signaling Through Up-regulation of Estrogen Receptor β (ERβ). Takeda S, Yoshida K, Nishimura H, Harada M, Okajima S, Miyoshi H, Okamoto Y, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. Abstract Δ9-Tetrahydrocannabinol (Δ9-THC) has been reported as possessing anti-estrogenic activity, although the mechanisms underlying these effects are poorly delineated. In this study, we used the estrogen receptor α (ERα)-positive human […]

Orexin neurons use endocannabinoids to break obesity-induced inhibition.

 [Epub ahead of print] Orexin neurons use endocannabinoids to break obesity-induced inhibition. Alpár A, Harkany T. Source Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. PMID:  23720305 [PubMed – as supplied by publisher]   http://www.ncbi.nlm.nih.gov/pubmed/23720305

Synaptic Zn2+ Inhibits Neurotransmitter Release by Promoting Endocannabinoid Synthesis.

J Neurosci. 2013 May 29;33(22):9259-9272. Synaptic Zn2+ Inhibits Neurotransmitter Release by Promoting EndocannabinoidSynthesis. Perez-Rosello T, Anderson CT, Schopfer FJ, Zhao Y, Gilad D, Salvatore SR, Freeman BA, Hershfinkel M, Aizenman E,Tzounopoulos T. Source Departments of Otolaryngology, Pharmacology and Chemical Biology, and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, and Department of Morphology, Ben-Gurion University, Faculty of Health Sciences, Beer-Sheva 84015, Israel. Abstract […]

Modulation of anxiety-like behaviour by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray.

 [Epub ahead of print] Modulation of anxiety-like behaviour by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. Almeida-Santos AF, Gobira PH, Rosa LC, Guimaraes FS, Moreira FA, Aguiar DC. Source Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Pres. Antônio Carlos 6627, 31270-901, Belo Horizonte, MG, Brazil. Abstract Anandamide and 2-arachidonoylglycerol (2-AG) are the […]

The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55.

[Epub ahead of print] The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55. Yamashita A, Oka S, Tanikawa T, Hayashi Y, Nemoto-Sasaki Y, Sugiura T. Source Faculty of Pharma-Sciences, Teikyo University, Kaga 2-11-1, Itabashi-Ku, Tokyo 173-8605, Japan. Electronic address: ayamashi@pharm.teikyo-u.ac.jp. Abstract Lysophosphatidylinositol (LPI) is a subspecies of lysophospholipid and is assumed to be not only a degradation product […]

Feasibility of targeting ischaemia-related ventricular arrhythmias by mimicry of endogenous protection by endocannabinoids.

   [Epub ahead of print]   Feasibility of targeting ischaemia-related ventricular arrhythmias by mimicry of endogenous protection by endocannabinoids.   Andrag E, Curtis MJ.   Source Cardiovascular Division, King’s College London, London, UK.   Abstract BACKGROUND AND PURPOSE: The hypothesis that endocannabinoids protect hearts against ventricular fibrillation (VF) induced by myocardial ischaemia and reperfusion was examined, […]

Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system.

Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. Shinjyo N, Piscitelli F, Verde R, Di Marzo V. Source Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R., Pozzuoli, (NA), Italy. Abstract Neural stem cells express cannabinoid CB1 and CB2 receptors and the enzymes for the biosynthesis and metabolism of endocannabinoids (eCBs). […]

Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors.

Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors. Pryce G, Cabranes A, Fernández-Ruiz J, Bisogno T, Di Marzo V, Long J, Cravatt B, Giovannoni G, Baker D. Source Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK. Abstract BACKGROUND: It has been previously shown that CB1 cannabinoid receptor agonism […]