Archive | July, 2013

Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats.

Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats. Campos AC, de Paula Soares V, Carvalho MC, Ferreira FR, Vicente MA, Brandão ML, Zuardi AW, Zangrossi H Jr, Guimarães FS. Source Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, 3900 Bandeirantes av., Monte Alegre, Ribeirão Preto, São Paulo, […]

Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection.

 [Epub ahead of print] Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection. da Silva VK, de Freitas BS, da Silva Dornelles A, Nery LR, Falavigna L, Ferreira RD, Bogo MR, Hallak JE,Zuardi AW, Crippa JA, Schröder N. Source Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, 90619-900, Porto Alegre, […]

Analysis of THCA synthase gene expression in cannabis: A preliminary study by real-time quantitative PCR.

Analysis of THCA synthase gene expression in cannabis: A preliminary study by real-time quantitative PCR. Cascini F, Passerotti S, Boschi I. Source Istituto di Sanità Pubblica, Sezione di Medicina Legale, Università Cattolica del Sacro Cuore, 00168 Roma, Italy. Electronic address: f.cascini@rm.unicatt.it. Abstract In this paper we describe analyses performed by Real-Time Reverse-Transcriptase Polymerase Chain Reaction (real-time RT-PCR) […]

Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus.

[Epub ahead of print] Br J Pharmacol. Oct 2013; 170(3): 641–648.  Published online Sep 17, 2013. doi:  10.1111/bph.12316 PMCID: PMC3792001 Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus E M Rock, R L Kopstick, C L Limebeer, and  L A Parker Author information ► Article notes ► Copyright and License information ► Go to: Abstract BACKGROUND AND PURPOSE We evaluated the anti-emetic […]

Endocannabinoid receptor (CB1R) deficiency affects maternal care and alters the dam’s hippocampal oxytocin receptor and BDNF expression.

 [Epub ahead of print] Endocannabinoid receptor (CB1R) deficiency affects maternal care and alters the dam’s hippocampal oxytocin receptor and BDNF expression. Schechter M, Weller A, Pittel Z, Gross M, Zimmer A, Pinhasov A. Source Department of Molecular Biology, Ariel University, Ariel, Israel; Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel; Gonda Brain Research Center, Bar Ilan University, Ramat-Gan, Israel. Abstract […]

Recent progress in prostaglandin f2α ethanolamide (prostamide f2α) research and therapeutics.

Recent progress in prostaglandin f2α ethanolamide (prostamide f2α) research and therapeutics. Woodward DF, Wang JW, Poloso NJ. Source Department of biological Sciences Allergan Inc., 2525 Dupont Drive, Irvine CA 92623-9534. woodward_david@allergan.com. Abstract Prostamide (prostaglandin ethanolamide) research emerged from two distinct lines of research: 1) the unique pharmacology of the antiglaucoma drug bimatoprost and 2) the discovery that endocannabinoidanandamide […]

Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH.

Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH. Chanda D, Kim YH, Li T, Misra J, Kim DK, Kim JR, Kwon J, Jeong WI, Ahn SH, Park TS, Koo SH, Chiang JY,Lee CH, Choi HS. Source National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea. […]

The use of cannabinoids in chronic pain.

BMJ Case Rep. 2013; 2013: bcr2013010417.  Published online 2013 Jul 26. doi:  10.1136/bcr-2013-010417 PMCID: PMC3736518 Case Report The use of cannabinoids in chronic pain Timothy David Reynolds1 and  Hannah Louise Osborn2 Author information ► Copyright and License information ► Go to: Abstract We present the case of a 56-year-old man who developed chronic pain following the excision of a facial cancer that was […]

Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype

 [Epub ahead of print] Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype. Kozela E, Juknat A, Kaushansky N, Rimmerman N, Ben-Nun A, Vogel Z. Source The Dr Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ewa.kozela@weizmann.ac.il. Abstract Cannabinoids, the Cannabis constituents, are known to possess anti-inflammatory properties but […]

Voltage drives diverse endocannabinoid signals to mediate striatal microcircuit-specific plasticity.

 [Epub ahead of print] Voltage drives diverse endocannabinoid signals to mediate striatal microcircuit-specific plasticity. Mathur BN, Tanahira C, Tamamaki N, Lovinger DM. Source Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA. Abstract The dorsolateral striatum and cannabinoid type 1 receptor (CB1) signaling mediate habitual action […]