Archive | August, 2013

Evidence for the involvement of cannabinoid receptors’ polymorphisms in the pathophysiology of human diseases.

Evidence for the involvement of cannabinoid receptors’ polymorphisms in the pathophysiology of human diseases. Vasileiou I, Fotopoulou G, Matzourani M, Patsouris E, Theocharis S. Source First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias street, GR11527, Goudi, Athens, Greece. Abstract INTRODUCTION: Considerable progress has been made, over the last years, in understanding the […]

Expression of the cannabinoid CB1 receptor in the gymnotiform fish brain and its implications for the organization of the teleost pallium.

Expression of the cannabinoid CB1 receptor in the gymnotiform fish brain and its implications for the organization of the teleost pallium. Harvey-Girard E, Giassi AC, Ellis W, Maler L. Source Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada K1H 8M5. erik@apteronote.com Abstract Cannabinoid CB1 receptors (CB1R) are widely distributed in the brains of many vertebrates, […]

Current knowledge on cannabinoids in oral fluid.

[Epub ahead of print] Current knowledge on cannabinoids in oral fluid. Lee D, Huestis MA. Source Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA. Abstract Oral fluid (OF) is a new biological matrix for clinical and forensic drug testing, offering non-invasive and directly observable sample collection […]

Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.

Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists Ken-ichi Kusakabea, , , Yukio Tadaa, Yasuyoshi Isoa, Masahiro Sakagamia, Yasuhide Moriokaa, Nobuo Chomeia, Satomi Shinonomea, Keiko Kawamotoa, Hideyuki Takenakaa, Kiyoshi Yasuia, Hiroshi Hamanab, Kohji Hanasakia a Medicinal Research Laboratories, Shionogi Pharmaceutical Research Center, 11-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan b Faculty of Pharmacy, Chiba Institute […]

Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats.

Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats. Fogaça MV, Gomes FV, Moreira FA, Guimarães FS, Aguiar DC. Source Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo 14049900, Brazil. Abstract RATIONALE: The […]

Stress peptide PACAP engages multiple signaling pathways within the carotid body to initiate excitatory responses in respiratory and sympathetic chemosensory afferents.

Stress peptide PACAP engages multiple signaling pathways within the carotid body to initiate excitatory responses in respiratory and sympathetic chemosensory afferents. Roy A, Derakhshan F, Wilson RJ. Source Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. Abstract Consistent with a critical role in respiratory and autonomic stress responses, […]

A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function

A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. Kargl J, Brown AJ, Andersen L, Dorn G, Schicho R, Waldhoer M, Heinemann A. Source Institute for Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria. julia.kargl@medunigraz.at Abstract The G protein-coupled receptor 55 (GPR55) is a lysophosphatidylinositol (LPI) receptor that is […]

Cannabinoid CB2 receptor gene (CNR2) polymorphism is associated with chronic childhood immune thrombocytopenia in Egypt.

Cannabinoid CB2 receptor gene (CNR2) polymorphism is associated with chronic childhood immune thrombocytopenia in Egypt. Mahmoud Gouda H, Mohamed Kamel NR. Source Clinical Pathology Department bPaediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt. goudamed@hotmail.com Abstract Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by thrombocytopenia with or without mucocutaneous bleeding manifestations. ITP patients have […]

The impact of adolescent social isolation on dopamine D2 and cannabinoid CB1 receptors in the adult rat prefrontal cortex

The impact of adolescent social isolation on dopamine D2 and cannabinoid CB1 receptors in the adult rat prefrontal cortex M.L. Fitzgeralda, K. Mackieb, V.M. Pickela, ,  a Department of Neuroscience, Brain and Mind Research Institute, Weill Cornell Medical College, 407 East 61st Street, New York, NY 10065, United States b Department of Psychological and Brain Sciences and the […]

A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine.

A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine. Notcutt WG. Source Pain Research Unit, James Paget University Hospital, Great Yarmouth, Norfolk, UK. William.Notcutt@JPAGET.NHS.UK Abstract AIM: To identify the areas of daily function most affected by the introduction of Sativex, a cannabis-based medicine, and the impact on caregivers and […]