Archive | January, 2014

Adolescent traumatic stress experience results in less robust conditioned fear and post-extinction fear cue responses in adult rats.

2014 Jan 31. pii: S0091-3057(14)00020-3. doi: 10.1016/j.pbb.2014.01.011. [Epub ahead of print] Adolescent traumatic stress experience results in less robust conditioned fear and post-extinction fear cue responses in adult rats. Moore NL1, Gauchan S2, Genovese RF2. Author information Abstract Early exposure to a traumatic event may produce lasting effects throughout the lifespan. Traumatic stress during adolescence may deliver […]

1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.

2014 Jan 31. pii: S0960-894X(14)00094-8. doi: 10.1016/j.bmcl.2014.01.064. [Epub ahead of print] 1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase. Keith JM1, Hawryluk N2, Apodaca RL2, Chambers A2, Pierce JM2, Seierstad M2, Palmer JA2, Webb M2, Karbarz MJ2, Scott BP2, Wilson SJ2, Luo L2,Wennerholm ML2, Chang L2, Rizzolio M2, Chaplan SR2, Breitenbucher JG2. Author information Abstract A series of 1-aryl-2-(((6-aryl)pyrimidin-4-yl)amino)ethanols have been found to be competitive inhibitors of fatty acid […]

Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

2014 Jan 30. doi: 10.1038/npp.2014.24. [Epub ahead of print] Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling. Zhong P1, Wang W1, Pan B1, Liu X1, Zhang Z2, Long JZ3, Zhang HT4, Cravatt BF3, Liu QS1. Author information Abstract The endocannabinoid (eCB) system regulates mood, emotion and stress coping, and dysregulation of the eCB system is critically involved in […]

Brain Innate Immunity In The Regulation Of Neuroinflammation: Therapeutic Strategies By Modulating Cd200-Cd200r Interaction Involve The Cannabinoid System.

2014 Jan 30. [Epub ahead of print] Current Pharmaceutical Design Bentham Science Publishers Curr Pharm Des. Sep 2014; 20(29): 4707–4722.  Published online Sep 2014. doi:  10.2174/1381612820666140130202911 PMCID: PMC4157566 Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System Miriam Hernangómez,1 Francisco J Carrillo-Salinas,1 Miriam Mecha,1 Fernando Correa,2 Leyre Mestre,1 Frida Loría,1Ana Feliú,1 Fabian Docagne,3 and  Carmen Guaza1,* Author […]

Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation.

2014 Jan 30. [Epub ahead of print] Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation. De Laurentiis A, Araujo HA, Rettori V1. Author information Abstract A few years ago the endocannabinoid system has been recognized as a major neuromodulatory system whose main functions are to exert and maintain the body homeostasis. Several different endocannabinoids […]

A Role for Trans-caryophyllene in the Moderation of Insulin Secretion

2014 Jan 30. pii: S0006-291X(14)00139-9. doi: 10.1016/j.bbrc.2013.11.136. [Epub ahead of print] A Role for Trans-caryophyllene in the Moderation of Insulin Secretion. Suijun W1, Zhen Y2, Ying G3, Yanfang W4. Author information Abstract Glucose-stimulated insulin secretion (GSIS) is essential for the control of metabolic fuel homeostasis and its impairment is a key element in the failure of β-cells in […]

Affinity comparison of different THCA synthase to CBGA using modeling computational approaches.

2014 Jan 29;10(1):33-8. doi: 10.6026/97320630010033. eCollection 2014. Bioinformation. 2014; 10(1): 33–38.  Published online Jan 29, 2014. doi:  10.6026/97320630010033 PMCID: PMC3916817 Affinity comparison of different THCA synthase to CBGA using modeling computational approaches Moulay Abdelaziz El Alaoui,1,2 Azeddine Ibrahimi,3 Oussama Semlali,3 Zineb Tarhda,3 Melloul Marouane,1,2 Alaoui Najwa,3 Abdelmajid Soulaymani,2 and  Elmostafa El Fahime1,* Author information ► Article notes ► Copyright and License information ► Go to: Abstract The Δ9-Tetrahydrocannabinol (THCA) is the […]

Dyskinesias in Parkinson’s disease: views from positron emission tomography studies.

 2014 Jan 28. doi: 10.1111/ene.12362. [Epub ahead of print] Dyskinesias in Parkinson’s disease: views from positron emission tomography studies. Niccolini F, Loane C, Politis M. Author information Abstract Levodopa-induced dyskinesias (LIDs) and graft-induced dyskinesias (GIDs) are serious and common complications of Parkinson’s disease (PD) management following chronic treatment with levodopa or intrastriatal transplantation with dopamine-rich foetal ventral […]

Regulatory role of the Cannabinoid-2 receptor in stress-induced neuroinflammation in mice.

2014 Jan 28. doi: 10.1111/bph.12607. [Epub ahead of print] Regulatory role of the Cannabinoid-2 receptor in stress-induced neuroinflammation in mice. Zoppi S, Madrigal JL, Caso JR, García-Gutiérrez MS, Manzanares J, Leza JC, García-Bueno B. Author information Abstract BACKGROUND AND PURPOSE: Stress-exposure produces excitoxicity and neuroinflammation, contributing to the cellular damage observed in stress-related neuropathologies. The endocannabinoid system is present in stress-responsive neural […]

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1.

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1 William John Redmond​1, Liuqiong Gu2, Maxime Camo1, Peter McIntyre2,3,Mark Connor1 Author and article information Abstract Background and purpose. Arachidonic acid (AA) and its derivatives are important modulators of cellular signalling. The transient receptor potential cation channel subfamily A, member 1 (TRPA1) is a cation channel with important functions in mediating cellular responses […]