Archive | April, 2014

Dyskinesia in Parkinson’s disease: mechanisms and current non pharmacological interventions.

2014 Apr 29. doi: 10.1111/jnc.12751. [Epub ahead of print] Dyskinesia in Parkinson’s disease: mechanisms and current non pharmacological interventions. Heumann R1, Moratalla R, Herrero MT, Chakrabarty K, Drucker-Colín R, Garcia-Montes JR, Simola N,Morelli M. Author information Abstract Dopamine replacement therapy in Parkinson’s disease is associated with several unwanted effects, of which dyskinesia is the most disabling. The development of new therapeutic […]

Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans.

2014 Apr 30;1(4):272-82. eCollection 2014. Sailler S1, Schmitz K1, Jäger E2, Ferreiros N1, Wicker S3, Zschiebsch K1, Pickert G1, Geisslinger G1, Walter C1, Tegeder I1, Lötsch J1. Author information Oncoscience. 2014; 1(4): 272–282.  Published online 2014 Apr 30.  PMCID: PMC4278301 Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans Sebastian Sailler,1 Katja Schmitz,1 Elke Jäger,2 Nerea Ferreiros,1 Sabine Wicker,3 Katja Zschiebsch,1 Geethanjali Pickert,1 Gerd Geisslinger,1 Carmen Walter,1 Irmgard Tegeder,#1 and  Jörn Lötsch#1 Author […]

Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.

 2014 Apr 30. doi: 10.1111/bph.12747. [Epub ahead of print] Meijerink J1, Poland M, Balvers MG, Plastina P, Lute C, Dwarkasing J, van Norren K, Witkamp RF. Author information Abstract BACKGROUND AND PURPOSE: DHEA (N-docosahexaenoylethanolamine) is the ethanolamine conjugate of the long chain polyunsaturated n-3 fatty acid DHA (docosahexaenoic; 22 : 6n-3). Its concentration in animal tissues and human plasma increases when diets […]

Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats.

 2014 Apr 30. pii: S0022-510X(14)00270-6. doi: 10.1016/j.jns.2014.04.034. [Epub ahead of print] Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats. Fujii M1, Sherchan P1, Krafft PR1, Rolland WB1, Soejima Y1, Zhang JH2. Author information Abstract Early brain injury (EBI), following subarachnoid hemorrhage (SAH), comprises blood-brain barrier (BBB) disruption and consequent edema formation. […]

Cannabinoid CB2 Receptor as a New Phototherapy Target for Inhibition of Tumor Growth.

 2014 Apr 29. [Epub ahead of print] Cannabinoid CB2 Receptor as a New Phototherapy Target for Inhibition of Tumor Growth. Jia N, Zhang S, Shao P, Bagia C, Janjic JM, Ding Y, Bai M. Abstract The success of targeted cancer therapy largely relies upon the selection of target and development of efficient therapeutic agents that specifically bind to the target. In the […]

Therapeutic benefits of cannabis: a patient survey.

Hawaii J Med Public Health. Apr 2014; 73(4): 109–111. PMCID: PMC3998228 Therapeutic Benefits of Cannabis: A Patient Survey Charles W Webb, MD and Sandra M Webb, RN, BSN Author information ► Copyright and License information ► Go to: Abstract Clinical research regarding the therapeutic benefits of cannabis (“marijuana”) has been almost non-existent in the United States since cannabis was given Schedule I status […]

The Cannabis Conundrum

Hawaii J Med Public Health. Apr 2014; 73(4): 104. PMCID: PMC3998226 The Cannabis Conundrum Michael J Meagher, MD, Co-Editor Author information ► Copyright and License information ► There is little that engenders more argument and polemic than a discussion of the legalization of Marijuana usage. As of this writing 21 states allow use of Cannabinoids for medical use and 2 states allow […]

CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats.

2014 Apr 27. [Epub ahead of print] CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats. Wills KL1, Vemuri K, Kalmar A, Lee A, Limebeer CL, Makriyannis A, Parker LA. Author information Abstract RATIONALE: Modulation of the endocannabinoid system has been found to interfere with opiate withdrawal. The potential of activation and blockade of the endocannabinoid system to prevent the aversive-affective […]

Latest Progress in the Identification of Novel Synthetic Ligands for the Cannabinoid CB2 Receptor.

2014 Apr 27. [Epub ahead of print] Latest Progress in the Identification of Novel Synthetic Ligands for the Cannabinoid CB2 Receptor. Han S, Jiong-Jiong C, Jian-Zhong C1. Author information Abstract Cannabinoid receptors, belonging to the superfamily of G-protein coupled receptors, play a major role in pathophysiology of a wide range of disparate diseases. Cannabinoid CB2 receptor, which mainly locates in peripheral tissues, […]

Should doctors prescribe cannabinoids?

2014 Apr 23;348:g2737. doi: 10.1136/bmj.g2737. Should doctors prescribe cannabinoids? Farrell M1, Buchbinder R, Hall W. Author information PMID:  24760158 [PubMed – in process] BMJ 2014; 348 doi: http://dx.doi.org/10.1136/bmj.g2737 (Published 23 April 2014) Cite this as: BMJ 2014;348:g2737 Uncertainties page Clinical trials (epidemiology) Drugs: CNS (not psychiatric) Pain (neurology) Health education More topics  Article Related content Read responses (1) Article metrics Michael Farrell, professor and […]