Archive | May, 2014

Passing the Alzheimer’s Test and One’s Cannabinoid System – an Update on the Bryan William Brickner Blog

Passing the Alzheimer’s Test and One’s Cannabinoid System – an Update on the Bryan William Brickner Blog Bryan W. Brickner highlights numerous 2014 research articles from the National Institutes of Health regarding Alzheimer’s disease – a relentless enemy worthy of mimicry – and one’s cannabinoid system. Time is both our ally and not. Chicago, IL […]

A diet containing a nonfat dry milk matrix significantly alters systemic oxylipins and the endocannabinoid 2-arachidonoylglycerol (2-AG) in diet-induced obese mice.

2014 May 30;11:24. doi: 10.1186/1743-7075-11-24. eCollection 2014. A diet containing a nonfat dry milk matrix significantly alters systemic oxylipins and the endocannabinoid 2-arachidonoylglycerol (2-AG) in diet-induced obese mice. Dunn TN1, Keenan AH2, Thomas AP3, Newman JW4, Adams SH4. Author information Abstract BACKGROUND: Diets rich in dairy and/or calcium (Ca) have been associated with reductions in adiposity and inflammation, but […]

Cross-Substitution of Δ9-Tetrahydrocannabinol and JWH-018 in Drug Discrimination in Rats.

2014 May 30. pii: S0091-3057(14)00159-2. doi: 10.1016/j.pbb.2014.05.016. [Epub ahead of print] Cross-Substitution of Δ9-Tetrahydrocannabinol and JWH-018 in Drug Discrimination in Rats. Wiley JL1, Lefever TW2, Cortes RA2, Marusich JA2. Author information Abstract Synthetic indole-derived cannabinoids, originally developed to probe cannabinoid CB1 and CB2 receptors, have become widely abused for their marijuana-like intoxicating properties. The present study examined the effects of indole-derived cannabinoids in rats trained […]

TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.

2014 May 29. [Epub ahead of print] TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective. Straub RH. Author information Abstract Chronic inflammatory diseases are accompanied by a systemic response of the body, necessary to redirect energy-rich fuels to the activated immune system […]

Business of Cannabinoids: Pharm Pills and Farm Herbs ~ New Publius on the Bryan William Brickner Blog

Business of Cannabinoids: Pharm Pills and Farm Herbs ~ New Publius on the Bryan William Brickner Blog Just as America plants new seeds for a new harvest, we need some new words for understanding the kinds of cannabinoid businesses forming. The cannabinoid system (CS) is fundamental to health: CS economics are as well. Chicago, IL […]

Stress regulates endocannabinoid-CB1 receptor signaling.

2014 May 29. pii: S1044-5323(14)00047-5. doi: 10.1016/j.smim.2014.04.001. [Epub ahead of print] Stress regulates endocannabinoid-CB1 receptor signaling. Hillard CJ. Author information Abstract The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. The endogenous ligands for the CB1 receptor (endocannabinoids) are N-arachidonylethanolamine and 2-arachidonoylglycerol; together the endocannabinoids and CB1R subserve activity […]

The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model.

2014 May 28. pii: S0197-4580(14)00384-4. doi: 10.1016/j.neurobiolaging.2014.05.021. [Epub ahead of print] The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. Fernández-Suárez D1, Celorrio M1, Riezu-Boj JI2, Ugarte A3, Pacheco R4, González H5, Oyarzabal J3, Hillard CJ6,Franco R7, Aymerich MS8. Author information Abstract Changes in cannabinoid receptor expression and concentration of endocannabinoids have been described in Parkinson’s […]

What we know and do not know about the cannabinoid receptor 2 (CB2).

2014 May 27. pii: S1044-5323(14)00048-7. doi: 10.1016/j.smim.2014.04.002. [Epub ahead of print] What we know and do not know about the cannabinoid receptor 2 (CB2). Malfitano AM1, Basu S2, Maresz K2, Bifulco M1, Dittel BN3. Author information Abstract It has been well appreciated that the endocannabinoid system can regulate immune responses via the cannabinoid receptor 2 (CB2), which is primarily expressed by cells of […]

The Endocannabinoid System – Back to the Scene of Cardiometabolic Risk Factors Control?

2014 May 27. [Epub ahead of print] The Endocannabinoid System – Back to the Scene of Cardiometabolic Risk Factors Control? Martins CJ1, Genelhu V1, Di Marzo V2, Francischetti EA1. Author information Abstract This review examines the impact of the endocannabinoid signaling system on metabolic and cardiovascular health and the new therapeutic strategies that selectively target dysfunctional endocannabinoid action […]

Roles of fatty acid ethanolamides (FAE) in traumatic and ischemic brain injury.

 2014 May 26. pii: S1043-6618(14)00081-4. doi: 10.1016/j.phrs.2014.05.009. [Epub ahead of print] Roles of fatty acid ethanolamides (FAE) in traumatic and ischemic brain injury. Esposito E1, Cordaro M1, Cuzzocrea S2. Author information Abstract Ethanolamides of long-chain fatty acids are a class of endogenous lipid mediators generally referred to as N-acylethanolamines (NAEs). NAEs include anti-inflammatory and analgesic palmitoylethanolamide, anorexic […]