Archive | August, 2014

Control of synaptic function by endocannabinoid-mediated retrograde signaling.

2014;90(7):235-50. Control of synaptic function by endocannabinoid-mediated retrograde signaling. Kano M. Author information Abstract Since the first reports in 2001, great advances have been made towards the understanding of endocannabinoid-mediated synaptic modulation. Electrophysiological studies have revealed that one of the two major endocannabinoids, 2-arachidonoylglycerol (2-AG), is produced from membrane lipids upon postsynaptic Ca(2+) elevation and/or […]

Role of cannabinoid receptors in hepatic fibrosis and apoptosis associated with bile duct ligation in rats.

2014 Aug 29. pii: S0014-2999(14)00626-8. doi: 10.1016/j.ejphar.2014.08.021. [Epub ahead of print] Role of cannabinoid receptors in hepatic fibrosis and apoptosis associated with bile duct ligation in rats. Mahmoud MF1, Sewefy SE2, Hasan RA3, Ibrahim A2. Author information Abstract This study assessed the effect of stimulation of CB2 receptors or CB1 blockade on fibrosis and apoptosis in rats subjected to bile duct ligation […]

Endocannabinoid degradation inhibition improves neurobehavioral function, blood brain barrier integrity, and neuroinflammation following mild traumatic brain injury.

2014 Aug 28. [Epub ahead of print] Endocannabinoid degradation inhibition improves neurobehavioral function, blood brain barrier integrity, and neuroinflammation following mild traumatic brain injury. Katz PS1, Sulzer JK, Impastato RA, Teng SX, Rogers EK, Molina P. Author information Abstract Traumatic brain injury (TBI) is an increasingly frequent and poorly understood condition lacking effective therapeutic strategies. Inflammation and oxidative stress are […]

Cannabinoids for Neuropathic Pain.

2014 Oct;18(10):451. Cannabinoids for Neuropathic Pain. Fine PG1, Rosenfeld MJ. Author information Abstract Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of […]

[Cannabinoid mouth spray brought help to a severely spastic young man].

2014;130(14):1452-4. [Cannabinoid mouth spray brought help to a severely spastic young man]. [Article in Finnish] Arvio M, Bjelogrlic-Laakso N, Salokivi T. Abstract Cannabinoid was licensed in 2012 for the treatment of spasticity associated with multiple sclerosis in Finland. Spasticity is one of the main symptoms in cerebral palsies and a risk factor of multiple painful anomalies of the skeletal […]

Regulation of cannabinoid receptor gene expression and endocannabinoid levels in lymphocyte subsets by IFN-β: a longitudinal study in multiple sclerosis patients.

2014 Aug 28. doi: 10.1111/cei.12443. [Epub ahead of print] Regulation of cannabinoid receptor gene expression and endocannabinoid levels in lymphocyte subsets by IFN-β: a longitudinal study in multiple sclerosis patients. Sánchez López AJ1, Román-Vega L, Ramil Tojeiro E, Giuffrida A, García-Merino A. Author information Abstract Evidence suggests the involvement of the cannabinoid system in the pathogenesis of MS. We studied CB1 and CB2 receptor gene […]

Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats.

2014 Aug 28;2(8). pii: e12108. doi: 10.14814/phy2.12108. Print 2014 Aug 1. Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Schaich CL1, Shaltout HA2, Brosnihan KB1, Howlett AC1, Diz DI1. Author information Abstract We investigated acute and chronic effects of CB1 cannabinoid receptor blockade in renin-angiotensin system-dependent hypertension using rimonabant (SR141716A), an orally […]

Differential Expression of Brain Cannabinoid Receptors between Repeatedly Stressed Males and Females may Play a Role in Age and Gender-Related Difference in Traumatic Brain Injury: Implications from Animal Studies.

2014 Aug 28;5:161. doi: 10.3389/fneur.2014.00161. eCollection 2014. Differential Expression of Brain Cannabinoid Receptors between Repeatedly Stressed Males and Females may Play a Role in Age and Gender-Related Difference in Traumatic Brain Injury: Implications from Animal Studies. Xing G, Carlton J, Jiang X, Wen J, Jia M, Li H. Author information Abstract Inconsistent gender differences in the outcome of TBI have been reported. […]

Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure-Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1).

2014 Aug 27. [Epub ahead of print] Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure-Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). German NA, Decker AM, Gilmour BP, Gay EA, Wiley JL, Thomas BF, Zhang Y. Abstract The recent discovery of allosteric modulators of the CB1 receptor including PSNCBAM-1 (4) has generated significant interest in CB1 receptor allosteric modulation. Here in the first […]