Archive | October, 2014

Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459.

 2014 Oct 29. [Epub ahead of print] Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459. Goonawardena AV1, Plano A, Robinson L, Ross R, Greig I, Pertwee RG, Hampson RE, Platt B, Riedel G. Author information  Abstract The brain endocannabinoid system is a potential target for the treatment of psychiatric and metabolic conditions. Here, a novel CB1 receptor antagonist […]

Cocaine-Induced Behavioral Sensitization Is Associated With Changes in the Expression of Endocannabinoid and Glutamatergic Signaling Systems in the Mouse Prefrontal Cortex.

 2014 Oct 31. pii: pyu024. doi: 10.1093/ijnp/pyu024. [Epub ahead of print] Cocaine-Induced Behavioral Sensitization Is Associated With Changes in the Expression of Endocannabinoid and Glutamatergic Signaling Systems in the Mouse Prefrontal Cortex. Blanco E1, Pavón FJ1, Palomino A1, Luque-Rojas MJ1, Serrano A1, Rivera P1, Bilbao A1, Alen F1, Vida M1, Suárez J1, Rodríguez de Fonseca F2. Author information Abstract BACKGROUND: Endocannabinoids modulate the glutamatergic excitatory […]

Cannabidiol Attenuates Sensorimotor Gating Disruption and Molecular Changes Induced by Chronic Antagonism of NMDA receptors in Mice.

2014 Oct 31. pii: pyu041. doi: 10.1093/ijnp/pyu041. [Epub ahead of print] Gomes FV1, Issy AC2, Ferreira FR2, Viveros MP2, Del Bel EA2, Guimarães FS2. Author information Abstract BACKGROUND: Preclinical and clinical data suggest that cannabidiol (CBD), a major non-psychotomimetic compound from Cannabis sativa, induces antipsychotic-like effects. However, the antipsychotic properties of repeated CBD treatment have been poorly investigated. Behavioral changes […]

Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats.

 2014 Oct 30;73C:356-365. doi: 10.1016/j.nbd.2014.10.018. [Epub ahead of print] Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats. Di Maio R1, Cannon JR2, Timothy Greenamyre J3. Author information  Abstract Repeated seizures are often associated with development of refractory chronic epilepsy, the most common form of which is temporal lobe epilepsy. G-protein-coupled cannabinoid receptors (CB1 and […]

Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury.

2014 Oct 30:1-7. [Epub ahead of print] Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. Ribeiro A1, Almeida VI, Costola-de-Souza C, Ferraz-de-Paula V, Pinheiro ML, Vitoretti LB, Gimenes-Junior JA, Akamine AT, Crippa JA, Tavares-de-Lima W, Palermo-Neto J. Author information  Abstract Abstract We have previously shown that the prophylactic treatment with cannabidiol (CBD) reduces inflammation in a model of acute […]

Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus.

 2014 Oct 29;34(44):14560-70. doi: 10.1523/JNEUROSCI.1310-14.2014. Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus. Haj-Dahmane S1, Shen RY2. Author information  Abstract Alpha 1-adrenergic receptors (α1-ARs) control the activity of dorsal raphe nucleus (DRn) serotonin (5-HT) neurons and play crucial role in the regulation of arousal and stress homoeostasis. However, the precise role of […]

2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation.

2014 Oct 29. [Epub ahead of print] 2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation. Pérez-Morales M1, Fajardo-Valdez A, Méndez-Díaz M, Ruiz-Contreras AE, Prospéro-García O. Author information  Abstract We have previously reported that maternal separation (MS) for 3 h daily during the first two postnatal weeks increases wakefulness, whereas it reduces sleep in […]

Endocannabinoids, Related Compounds and Their Metabolic Routes.

 2014 Oct 24;19(11):17078-17106. Endocannabinoids, Related Compounds and Their Metabolic Routes. Fezza F1, Bari M2, Florio R3, Talamonti E4, Feole M5, Maccarrone M6. Author information  Abstract Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, […]

Cannabinoid Type 1 and Type 2 Receptor Antagonists Prevent Attenuation of Serotonin-Induced Reflex Apneas by Dronabinol in Sprague-Dawley Rats.

Michael W. Calik mail, David W. Carley Published: October 28, 2014, DOI: 10.1371/journal.pone.0111412 Cannabinoid Type 1 and Type 2 Receptor Antagonists Prevent Attenuation of Serotonin-Induced Reflex Apneas by Dronabinol in Sprague-Dawley Rats Abstract The prevalence of obstructive sleep apnea (OSA) in Americans is 9% and increasing. Increased afferent vagal activation may predispose to OSA by reducing upper […]