Archive | December, 2014

Neurobiological alterations in alcohol addiction: a review.

 2014;26(4):360-370. Neurobiological alterations in alcohol addiction: a review. Erdozain AM, Callado LF. Abstract The exact mechanism by which ethanol exerts its effects on the brain is still unknown. However, nowadays it is well known that ethanol interacts with specific neuronal membrane proteins involved in signal transmission, resulting in changes in neural activity. In this review different […]

A potential role for cannabinoid receptors in the therapeutic action of fenofibrate.

2014 Dec 30. pii: fj.14-263053. [Epub ahead of print] A potential role for cannabinoid receptors in the therapeutic action of fenofibrate. Priestley RS1, Nickolls SA2, Alexander SP1, Kendall DA3. Author information Abstract Cannabinoids are reported to have actions through peroxisome proliferator-activated receptors (PPARs), which led us to investigate PPAR agonists for activity at the cannabinoid receptors. Radio-ligand binding and functional assays were conducted […]

The role of AMP-activated protein kinase (AMPK) in the androgenic potentiation of cannabinoid-induced changes in energy homeostasis.

2014 Dec 30:ajpendo.00421.2014. doi: 10.1152/ajpendo.00421.2014. [Epub ahead of print] The role of AMP-activated protein kinase (AMPK) in the androgenic potentiation of cannabinoid-induced changes in energy homeostasis. Borgquist A1, Meza C1, Wagner EJ2. Author information Abstract Orexigenic mediators can impact the hypothalamic feeding circuitry via the activation of AMP-dependent protein kinase (AMPK). Given that testosterone is an orexigenic hormone, […]

Activation of cannabinoid receptor 2 attenuates synovitis and joint distruction in collagen-induced arthritis.

2014 Dec 30. pii: S0171-2985(14)00281-2. doi: 10.1016/j.imbio.2014.12.012. [Epub ahead of print] Gui H1, Liu X2, Liu LR3, Su DF4, Dai SM5. Author information Abstract OBJECTIVES: Recent studies have suggested immunomodulatory and anti-inflammatory effects of cannabinoid receptor 2 (CB2R) activation, which is devoid of psychoactivity. We have demonstrated the expression of CB2R in synovial tissue from patients with rheumatoid arthritis (RA), and […]

Endocannabinoid Signaling within the Basolateral Amygdala Integrates Multiple Stress Hormone Effects on Memory Consolidation.

2014 Dec 30. doi: 10.1038/npp.2014.334. [Epub ahead of print] Endocannabinoid Signaling within the Basolateral Amygdala Integrates Multiple Stress Hormone Effects on Memory Consolidation. Atsak P1, Hauer D2, Campolongo P3, Schelling G4, Fornari RV5, Roozendaal B1. Author information Abstract Glucocorticoid hormones are known to act synergistically with other stress-activated neuromodulatory systems, such as norepinephrine and corticotropin-releasing factor (CRF), within the basolateral complex […]

Re-branding cannabis: the next generation of chronic pain medicine?

2015 Jan;5(1):13-21. doi: 10.2217/pmt.14.49. Re-branding cannabis: the next generation of chronic pain medicine? Carter GT1, Javaher SP, Nguyen MH, Garret S, Carlini BH. Author information Abstract SUMMARY  The field of pain medicine is at a crossroads given the epidemic of addiction and overdose deaths from prescription opioids. Cannabis and its active ingredients, cannabinoids, are a much safer therapeutic option. Despite […]

Elevated CB1 and GPR55 receptor expression in proximal tubule cells and whole kidney exposed to diabetic conditions.

2014 Dec 29. doi: 10.1111/1440-1681.12355. [Epub ahead of print] Elevated CB1 and GPR55 receptor expression in proximal tubule cells and whole kidney exposed to diabetic conditions. Jenkin KA1, McAinch AJ, Zhang Y, Kelly DJ, Hryciw DH. Author information Abstract Hyperglycaemia increases the risk of developing diabetic nephropathy, with primary targets in the glomerulus and proximal tubule. Importantly, glomerular damage […]

Cannabinoid Modulation of Amygdala Subregion Functional Connectivity to Social Signals of Threat.

2014 Dec 28. pii: pyu104. doi: 10.1093/ijnp/pyu104. [Epub ahead of print] Cannabinoid Modulation of Amygdala Subregion Functional Connectivity to Social Signals of Threat. Gorka SM1, Fitzgerald DA2, de Wit H3, Phan KL4. Author information Abstract Δ9-tetrahydrocannabinol (THC) has been shown to modulate anxiety and facilitate the extinction of fear by inhibiting amygdala reactivity. Since functional coupling between the amygdala […]

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders.

Pharmacology & Therapeutics Available online 27 December 2014 In Press, Accepted Manuscript — Note to users Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders N. Singewalda, , 1, , C. Schmuckermaira, 1, N. Whittlea, A. Holmesb, K.J. Resslerc  Show more doi:10.1016/j.pharmthera.2014.12.004 Get rights and content Under a Creative Commons license   Open Access Abstract Pathological fear and […]

Effect of styrene maleic acid WIN55,212-2 micelles on neuropathic pain in a rat model.

2014 Dec 26:1-7. [Epub ahead of print] Effect of styrene maleic acid WIN55,212-2 micelles on neuropathic pain in a rat model. Linsell O1, Brownjohn PW, Nehoff H, Greish K, Ashton JC. Author information Abstract Abstract Cannabinoid receptor agonists are moderately effective at reducing neuropathic pain but are limited by psychoactivity. We developed a styrene maleic acid (SMA) based on the cannabinoid WIN 55,212-2 […]