Archive | May, 2015

Proving personal use: the admissibility of evidence negating intent to distribute marijuana.

2015 May;113(7):1255-70. Mayer S. Abstract Against the backdrop of escalating state efforts to decriminalize marijuana, U.S. Attorneys’ Offices continue to bring drug-trafficking prosecutions against defendants carrying small amounts of marijuana that are permitted under state law. Federal district courts have repeatedly barred defendants from introducing evidence that they possessed this marijuana for their own personal […]

Identification of prostamides, fatty acyl ethanolamines and their biosynthetic precursors in rabbit cornea.

2015 May 31. pii: jlr.M055772. [Epub ahead of print] Urquhart P1, Wang J2, Woodward DF2, Nicolaou A3. Author information Abstract Arachidonoyl ethanolamine (anandamide) and prostaglandin ethanolamines (prostamides) are biologically active derivatives of arachidonic acid. Although available through different precursor phospholipids, there is considerable overlap between the biosynthetic pathways of arachidonic acid-derived eicosanoids and anandamide-derived prostamides. Prostamides exhibit physiological […]

An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction

 2015 May 30. pii: S0306-4522(15)00498-4. doi: 10.1016/j.neuroscience.2015.05.056. [Epub ahead of print] Hutch C1, Hillard CJ2, Jia C3, Hegg CC4. Author information Abstract Endocannabinoids modulate a diverse array of functions including progenitor cell proliferation in the central nervous system, and odorant detection and food intake in the mammalian central olfactory system and larval Xenopus laevis peripheral olfactory system. However, […]

A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice.

2015 May 29. pii: S0024-3205(15)00280-5. doi: 10.1016/j.lfs.2015.05.005. [Epub ahead of print] Ronca RD1, Myers AM2, Ganea D3, Tuma RF1, Walker EA2, Ward SJ4. Author information Abstract AIMS: We have recently demonstrated that treatment with a cannabinoid CB2 agonist was protective in a mouse middle cerebral artery occlusion model of cerebral ischemia/reperfusion injury. The present study aimed to determine whether these protective effects […]

In vivo potency of different ligands on voltage-gated sodium channels.

2015 May 29. pii: S0014-2999(15)30039-X. doi: 10.1016/j.ejphar.2015.05.053. [Epub ahead of print] Safrany-Fark A1, Petrovszki Z2, Kekesi G3, Liszli P4, Benedek G5, Keresztes C6, Horvath G7. Author information Abstract The Ranvier nodes of thick myelinated nerve fibers contain almost exclusively voltage-gated sodium channels (Navs), while the unmyelinated fibers have several receptors (e.g., cannabinoid, transient receptor potential vanilloid receptor 1), too. Therefore, a nerve […]

Cannabidiol for the Prevention of Graft-Versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Results of a Phase II Study.

 2015 May 29. pii: S1083-8791(15)00375-4. doi: 10.1016/j.bbmt.2015.05.018. [Epub ahead of print] Yeshurun M1, Shpilberg O2, Herscovici C2, Shargian L2, Dreyer J3, Peck A3, Israeli M4, Levy-Assaraf M5, Gruenewald T6, Mechoulam R7, Raanani P2, Ram R2. Author information Abstract BACKGROUND: Graft-versus-host-disease (GVHD) is a major obstacle to successful allogeneic hematopoietic cell transplantation (alloHCT). Cannabidiol (CBD), a non-psychotropic ingredient of Cannabis sativa possesses potent anti-inflammatory and immunosuppressive properties. We hypothesized […]

High prevalence of cannabis use among Aka foragers of the Congo Basin and its possible relationship to helminthiasis.

2015 May 29. doi: 10.1002/ajhb.22740. [Epub ahead of print] Roulette CJ1, Kazanji M2, Breurec S2, Hagen EH1. Author information Abstract OBJECTIVES: Little is known about cannabis use in hunter-gatherers. Therefore, we investigated cannabis use in the Aka, a population of foragers of the Congo Basin. Because cannabis contains anthelminthic compounds, and the Aka have a high prevalence of […]

Psychosocial sequelae of cannabis use and implications for policy: findings from the Christchurch Health and Development Study.

 2015 May 26. [Epub ahead of print] Fergusson DM1, Boden JM, Horwood LJ. Author information Abstract BACKGROUND: The Christchurch Health and Development Study is a longitudinal study of a birth cohort of 1265 children who were born in Christchurch, New Zealand, in 1977. This cohort has now been studied from birth to the age of 35. SCOPE […]

Intrusive growth of primary and secondary phloem fibres in hemp stem determines fibre bundle formation and structure.

2015 May 27. pii: plv061. [Epub ahead of print] Snegireva A1, Chernova T1, Ageeva M1, Lev-Yadun S2, Gorshkova T3. Author information Abstract Plant fibres -cells with important mechanical functions and a widely used raw material – are usually identified in microscopic sections only after reaching a significant length or after developing a thickened cell wall. We characterized the early […]

The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease.

2014 Aug 21. [Epub ahead of print] The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease. Bedse G1, Romano A2, Lavecchia AM2, Cassano T3, Gaetani S2. Author information Abstract Alzheimer’s disease (AD) is the most common form of progressive neurodegenerative disease characterized by cognitive impairment and mental disorders. The actual cause and cascade of […]