Archive | June, 2015

Influence of rimonabant treatment on peripheral blood mononuclear cells; flow cytometry analysis and gene expression profiling.

2015 Jun 30;3:e1056. doi: 10.7717/peerj.1056. eCollection 2015. Almestrand S1, Wang X1, Jeppsson-Ahlberg Å2, Nordgren M1, Flygare J1, Christensson B1, Rössner S3, Sander B1. Author information Abstract The cannabinoid receptor type 1 (CB1) antagonist rimonabant has been used as treatment for obesity. In addition, anti-proliferative effects on mitogen-activated leukocytes have been demonstrated in vitro. We have previously shown that rimonabant (SR141716A) induces cell death in […]

No additive effect of cannabis on cognition in schizophrenia.

 2015 Jul 30. pii: S0920-9964(15)00356-4. doi: 10.1016/j.schres.2015.06.026. [Epub ahead of print] Power BD1, Dragovic M2, Badcock JC3, Morgan VA3, Castle D4, Jablensky A3, Stefanis NC2. Author information Abstract BACKGROUND: We aimed to examine the association between lifetime cannabis use and estimates of both premorbid and current cognitive function in psychotic disorders in an Australian cohort. METHODS: In an Australian multicenter cohort, 1237 participants […]

Cognitive and autonomic determinants of energy homeostasis in obesity.

2015 Jun 30. doi: 10.1038/nrendo.2015.103. [Epub ahead of print] Richard D1. Author information Abstract Obesity ensues from an imbalance between energy intake and expenditure that results from gene-environment interactions, which favour a positive energy balance. A society that promotes unhealthy food and encourages sedentary lifestyle (that is, an obesogenic environment) has become a major contributory […]

Endocannabinoid signaling in female reproductive events: a potential therapeutic target?

2015 Jun 30:1-5. [Epub ahead of print] Maccarrone M1. Author information Abstract Nearly 30 years after the discovery in 1964 of the psychoactive ingredient of cannabis (Cannabis sativa), Δ9-tetrahydrocannabinol, its endogenouscounterparts were discovered and collectively termed endocannabinoids (eCBs): N-arachidonoylethanolamine (anandamide) in 1992 and 2-arachidonoylglycerol in 1995. Since then, intense research has identified additional eCBs and an ensemble of […]

Sperm Release from the Oviductal Epithelium Depends on Ca2+ Influx Upon Activation of CB1 and TRPV1 by Anandamide.

2015 Jun 30. doi: 10.1002/jcb.25273. [Epub ahead of print] Gervasi MG1,2, Osycka-Salut C2, Sanchez T3, Alonso C2, Llados C3, Castellano L2, Franch AM4, Villalón M3, Perez-Martinez S2. Author information Abstract The oviduct acts as a functional sperm reservoir in many mammalian species. Both binding and release of spermatozoa from the oviductal epithelium are mainly modulated by sperm capacitation. Several molecules from oviductal fluid […]

Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro venomous pit viper snake.

2015 Jun 30. pii: S0306-4522(15)00589-8. doi: 10.1016/j.neuroscience.2015.06.048. [Epub ahead of print] Almada RC1, Roncon CM2, Elias-Filho DH1, Coimbra NC3. Author information Abstract The substantia nigra pars reticulata (SNpr) is rich in -aminobutyric acid (GABA)-ergic neurons and connected to mesencephalic tectum (MT) structures, such as the superior colliculus and dorsal periaqueductal gray matter. The SNpr presents a high density […]

Validation of endogenous control reference genes for normalising gene expression in studies of endometrial carcinoma.

2015 Jun 29. pii: gav033. [Epub ahead of print] Ayakannu T1, Taylor AH1, Willets JM1, Brown L2, Lambert DG3, McDonald J3, Davies Q4, Moss EL4, Konje JC5. Author information Abstract Real time quantitative RT-PCR (qRT-PCR) is a powerful technique used for the relative quantification of target genes, using reference (housekeeping) genes for normalisation to ensure the generation of accurate and robust data. A […]

Cannabinoid and nitric oxide signalling interplay in the modulation of hippocampal hyperexcitability: study on electrophysiological and behavioural models of temporal lobe epilepsy in the rat.

2015 Jun 29. pii: S0306-4522(15)00588-6. doi: 10.1016/j.neuroscience.2015.06.047. [Epub ahead of print] Carletti F1, Gambino G2, Rizzo V3, Ferraro G2, Sardo P4. Author information Abstract A growing bulk of evidence suggests that cannabinoid system plays a pivotal role in the control of hyperexcitability phenomena. Notwithstanding, the anticonvulsant action of cannabinoids has not been fully addressed, in particular the involvement of potential cellular neuromodulators, for […]

Circulating endocannabinoids during hematopoietic stem cell transplantation: A pilot study.

2015;2:44-50. Knight JM1, Szabo A2, Zhao S2, Lyness JM3, Sahler OJ4, Liesveld JL5, Sander T6, Rizzo JD7, Hillard CJ8, Moynihan JA3. Author information Abstract OBJECTIVE: Hematopoietic stem cell transplantation (HCT) is a stressful and rigorous medical procedure involving significant emotional and immune challenges. The endocannabinoid (eCB) signaling system is involved in regulation of both the immune system and emotional reactivity, yet little is known […]

Modulatory effects by CB1 receptors on rat spinal locomotor networks after sustained application of agonists or antagonists.

2015 Jun 27. pii: S0306-4522(15)00586-2. doi: 10.1016/j.neuroscience.2015.06.045. [Epub ahead of print] Veeraraghavan P1, Nistri A2. Author information Abstract Sustained administration of cannabinoid agonists acting on neuronal CB1 receptors (CB1Rs) are proposed for treating spasticity and chronic pain. The impact of CB1Rs on mammalian locomotor networks remains, however, incompletely understood. To clarify how CB1Rs may control synaptic activity and […]