Archive | October, 2015

Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity.

 2015 Oct 31. pii: S0278-5846(15)30054-3. doi: 10.1016/j.pnpbp.2015.10.010. [Epub ahead of print] Dunbar M1, de la Tremblaye PB1, Azogu I1, Plamondon H2. Author information Abstract Global cerebral ischemia in rodents, which mimics cardiac arrest in humans, is associated with a surge in endocannabinoids and increased transmission of dopamine and glutamate leading to excitotoxic cell death. The current study assessed the role […]

Cannabinoid Transmission in the Hippocampus Activates Nucleus Accumbens Neurons and Modulates Reward and Aversion-Related Emotional Salience.

2015 Oct 31. pii: S0006-3223(15)00900-2. doi: 10.1016/j.biopsych.2015.10.016. [Epub ahead of print] Loureiro M1, Kramar C2, Renard J2, Rosen LG2, Laviolette SR3. Author information Abstract BACKGROUND: Cannabinoid receptor transmission strongly influences emotional processing, and disturbances in cannabinoid signaling are associated with various neuropsychiatric disorders. The mammalian ventral hippocampus (vHipp) is a critical neural region controlling mesolimbic activity via glutamatergic projections to the nucleus […]

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.

Journal List HHS Author Manuscripts PMC4851925 Eur J Pain. Author manuscript; available in PMC 2016 Jul 1. Published in final edited form as: Eur J Pain. 2016 Jul; 20(6): 936–948. Published online 2015 Oct 30. doi:  10.1002/ejp.818 PMCID: PMC4851925 NIHMSID: NIHMS737474 D.C. Hammell,1,a L.P. Zhang,2,a F. Ma,2 S.M. Abshire,2 S.L. McIlwrath,2 A.L. Stinchcomb,1 and K.N. […]

Fluoxetine Facilitates Fear Extinction through Amygdala Endocannabinoids.

2015 Oct 30. doi: 10.1038/npp.2015.318. [Epub ahead of print] Gunduz-Cinar O1, Flynn S1, Brockway E1, Kaugars K1, Baldi R2, Ramikie TS2, Cinar R3, Kunos G3, Patel S2, Holmes A1. Author information Abstract Pharmacologically elevating brain endocannabinoids (eCBs) shares anxiolytic and fear extinction-facilitating properties with classical therapeutics, including the selective serotonin reuptake inhibitor, fluoxetine. There are also known functional interactions between the eCB and serotonin systems and […]

Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity.

2015 Oct 30;10(10):e0141600. doi: 10.1371/journal.pone.0141600. Anthony Jalin AM1, Rajasekaran M2, Prather PL2, Kwon JS3, Gajulapati V3, Choi Y3, Kim C4, Pahk K1, Ju C1, Kim WK1. Author information Abstract Growing evidence suggests that therapeutic strategies to modulate the post-ischemic inflammatory responses are promising approaches to improve stroke outcome. Although the endocannabinoid system has been emerged as an endogenous therapeutic target to regulate inflammation after […]

Activation and allosteric modulation of human μ opioid receptor in molecular dynamics.

2015 Oct 30. [Epub ahead of print] Bartuzi D, Kaczor AA, Matosiuk D. Abstract Allosteric protein modulation gains an increasing attention in drug design. Its application as a mechanism of action could bring forth safer and more effective medicines. Targeting opioid receptors with allosteric modulators can result in better treatment of pain, depression, respiratory and immune disorders. […]

An Introduction to the Endogenous Cannabinoid System.

2015 Oct 30. pii: S0006-3223(15)00869-0. doi: 10.1016/j.biopsych.2015.07.028. [Epub ahead of print] Lu HC1, Mackie K2. Author information Abstract The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays important roles in central nervous system development, synaptic plasticity, and the response to endogenous and environmental insults. The ECS comprises cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes responsible for the […]

The cannabis crop

Julie Gould Nature 525, S2–S3 (24 September 2015) doi:10.1038/525S2a Published online 23 September 2015   Cannabis is one of humanity’s oldest cultivated crops. But despite its long history and many uses, hard facts on its evolution and impact on the human body are in short supply. By Julie Gould. WHAT IS WEED? Various strains of […]

Hempseed Products Fed to Hens Effectively Increased n-3 Polyunsaturated Fatty Acids in Total Lipids, Triacylglycerol and Phospholipid of Egg Yolk.

 2015 Oct 29. [Epub ahead of print] Neijat M1, Suh M2,3, Neufeld J2, House JD4,5,6,7. Author information Abstract Hempseed products represent potential alternative feed ingredients for poultry. However, their usage is not currently approved due to a lack of data to support their safety and efficacy. In this regard, the current study was conducted to assess the impact of […]

Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling.

2015 Oct 29;5(4):456-493. Basavarajappa BS1,2,3. Author information Abstract One of the unique features of prenatal alcohol exposure in humans is impaired cognitive and behavioral function resulting from damage to the central nervous system (CNS), which leads to a spectrum of impairments referred to as fetal alcohol spectrum disorder (FASD). Human FASD phenotypes can be reproduced […]