Archive | December, 2015

Low-Dose Cannabinoid Type 2 Receptor Agonist Attenuates Tolerance to Repeated Morphine Administration via Regulating μ-Opioid Receptor Expression in Walker 256 Tumor-Bearing Rats.

2015 Dec 30. [Epub ahead of print] Zhang M1, Wang K, Ma M, Tian S, Wei N, Wang G. Author information Abstract BACKGROUND: Morphine is widely used in patients with moderate and severe cancer pain, whereas the development of drug tolerance remains a major problem associated with opioid use. Previous studies have shown that cannabinoid type 2 (CB2) receptor agonists induce morphine […]

Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.

2016;2016:9815092. doi: 10.1155/2016/9815092. Epub 2015 Dec 29. Kruk-Slomka M1, Boguszewska-Czubara A2, Slomka T3, Budzynska B1, Biala G1. Author information Abstract The endocannabinoid system, through cannabinoid (CB) receptors, is involved in memory-related responses, as well as in processes that may affect cognition, like oxidative stress processes. The purpose of the experiments was to investigate the impact of CB1 and CB2 receptor ligands […]

Expression and Function of the Endocannabinoid System in the Retina and the Visual Brain.

2016;2016:9247057. doi: 10.1155/2016/9247057. Epub 2015 Dec 29.Bouchard JF1, Casanova C2, Cécyre B3, Redmond WJ3. Author information Abstract Endocannabinoids are important retrograde modulators of synaptic transmission throughout the nervous system. Cannabinoid receptors are seven transmembrane G-protein coupled receptors favoring Gi/o protein. They are known to play an important role in various processes, including metabolic regulation, craving, pain, anxiety, and immune function. In […]

Stress and memory: A selective review on recent developments in the understanding of stress hormone effects on memory and their clinical relevance.

 2015 Dec 28. doi: 10.1111/jne.12353. [Epub ahead of print] Wolf OT1, Atsak P2, de Quervain DJ3, Roozendaal B2, Wingenfeld K4. Author information Abstract Stress causes a neuroendocrine response cascade, leading to the release of catecholamines and glucocorticoids (GCs). GCs influence learning and memory by acting on the mineralocorticoid (MR) and glucocorticoid (GR) receptor. Typically, GCs enhance the consolidation of […]

Pharmacotherapy of alcoholic liver disease in clinical practice.

 2015 Dec 28. doi: 10.1111/ijcp.12764. [Epub ahead of print] Rosato V1, Abenavoli L2, Federico A3, Masarone M4, Persico M4. Author information Abstract AIMS: Alcohol is the most commonly used addictive substance and alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide, responsible for 47.9% of all liver chronic deaths. Despite ALD has a significant burden […]

Anti‑carcinogenic activity of anandamide on human glioma in vitro and in vivo.

 2015 Dec 28. doi: 10.3892/mmr.2015.4721. [Epub ahead of print] Ma C1, Wu TT2, Jiang PC1, Li ZQ1, Chen XJ1, Fu K1, Wang W1, Gong R1. Author information Abstract The poor prognosis of gliomas is to a large extent attributed to the markedly proliferative and invasive nature of the disease. Endocannabinoids have emerged as novel potential anti‑tumor agents. The present study aimed to investigate the […]

Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis.

2015 Dec 28. doi: 10.1038/npp.2015.367. [Epub ahead of print] Haney M1, Malcolm RJ2, Babalonis S3, Nuzzo PA3, Cooper ZD1, Bedi G1, Gray KM2, McRae-Clark A2, Lofwall MR3, Sparenborg S4, Walsh SL3. Author information Abstract Cannabidiol (CBD), a constituent of cannabis with few psychoactive effects, has been reported in some studies to attenuate certain aspects of Δ9-tetrahydrocannabinol (THC) intoxication. However, most studies have tested only one dose […]

Evaluation of the role of the cannabidiol system in an animal model of ischemia/reperfusion kidney injury.

2015 Dec;27(4):383-389. [Article in English, Portuguese] Soares RZ1, Vuolo F1, Dall’Igna DM1, Michels M1, Crippa JA2, Hallak JE2, Zuardi AW2, Dal-Pizzol F1. Author information Abstract OBJECTIVE: This work aimed to investigate the effects of the administration of cannabidiol in a kidney ischemia/reperfusion animal model. METHODS: Kidney injury was induced by 45 minutes of renal ischemia followed by reperfusion. Cannabidiol (5mg/kg) was administered immediately after reperfusion. RESULTS: […]

Cannabinoid-induced autophagy: protective or death role?

2015 Dec 27. pii: S1098-8823(15)30023-X. doi: 10.1016/j.prostaglandins.2015.12.006. [Epub ahead of print] Costa L1, Amaral C2, Teixeira N2, Georgina CD2, Fonseca BM3. Author information Abstract Autophagy, the “self-digestion” mechanism of the cells, is an evolutionary conserved catabolic process that targets portions of cytoplasm, damaged organelles and proteins for lysosomal degradation, which plays a crucial role in development and disease. Cannabinoids are active […]

Blockade of Cannabinoid 1 Receptor Improves GLP-1R Mediated Insulin Secretion in Mice.

2015 Dec 24. pii: S0303-7207(15)30171-4. doi: 10.1016/j.mce.2015.12.015. [Epub ahead of print] González-Mariscal I1, Krzysik-Walker SM1, Kim W2, Rouse M1, Egan JM1. Author information Abstract The cannabinoid 1 receptor (CB1) is an important regulator of energy metabolism. Reports of in vivo and in vitro studies give conflicting results regarding its role in insulin secretion, possibly due to circulatory factors, such […]