Archive | January, 2016

METABOLOMIC-DRIVEN ELUCIDATION OF SERUM DISTURBANCES ASSOCIATED WITH ALZHEIMER´S DISEASE AND MILD COGNITIVE IMPAIRMENT.

 2016 Jan 28. [Epub ahead of print] González-Domínguez R, Rupérez FJ, García-Barrera T, Barbas C, Gómez-Ariza JL1. Author information Abstract Numerous efforts have been made in the last years to discover potential biomarkers of Alzheimer’s disease and its progression from mild cognitive impairment, considered as an intermediate phase in the development of Alzheimer’s disease from normal aging. However, there […]

The molecular mechanism and effect of cannabinoid-2 receptor agonist on the blood-spinal cord barrier permeability induced by ischemia-reperfusion injury.

2016 Jan 30. pii: S0006-8993(16)30024-5. doi: 10.1016/j.brainres.2016.01.047. [Epub ahead of print] Yang MC1, Zhang HZ1, Wang Z1, You FL1, Wang YF2. Author information Abstract Previous studies have shown that modulation of the receptor-mediated endocannabinoid system during ischemia injury can induce potent neuroprotective effects. However, little is known about whether cannabinoid-2 (CB2) receptor agonist would produce a protective effect on […]

A selective CB2R agonist (JWH133) restores neuronal circuit after Germinal Matrix Hemorrhage in the preterm via CX3CR1+ microglia.

Neuropharmacology. 2017 Jan 30. pii: S0028-3908(17)30028-X. doi: 10.1016/j.neuropharm.2017.01.027. [Epub ahead of print] Tang J1, Miao H1, Jiang B1, Chen Q1, Tan L1, Tao Y1, Zhang J1, Gao F2, Feng H1, Zhu G3, Chen Z4. Author information Abstract Microglia play dual roles after germinal matrix hemorrhage, and the neurotrophic phenotype maybe neuroprotective. However, the phenotype transformation and the way by which neuron-microglia dialogue remain unclear. We raise […]

The potential relevance of the endocannabinoid, 2-arachidonoylglycerol, in diffuse large B-cell lymphoma.

2016 Jan 30;3(1):31-41. eCollection 2016. Zhang J1, Medina-Cleghorn D2, Bernal-Mizrachi L3, Bracci PM4, Hubbard A5, Conde L1, Riby J1, Nomura DK2, Skibola CF1. Author information Abstract Diffuse large B-cell lymphoma is an aggressive, genetically heterogenerous disease and the most common type of non-Hodgkin lymphoma among adults. To gain further insights into the etiology of DLBCL and to discover potential disease-related factors, we performed […]

Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity.

2016 Jan 29. doi: 10.3892/ijmm.2016.2475. [Epub ahead of print] Chen CC1, Lee TY2, Kwok CF3, Hsu YP4, Shih KC3, Lin YJ1, Ho LT1. Author information Abstract Hepatic glucose production is promoted by forkhead box O1 (FoxO1) under conditions of insulin resistance. The overactivity of cannabinoid receptor type 1 (CB1R) partly causes increased liver fat deposits and metabolic dysfunction in obese rodents by decreasing mitochondrial function. The aim […]

Endocannabinoids in Cerebrovascular Regulation.

2016 Jan 29:ajpheart.00571.2015. doi: 10.1152/ajpheart.00571.2015. [Epub ahead of print] Benyó Z1, Ruisanchez É2, Leszl-Ishiguro M2, Sándor P2, Pacher P3. Author information Abstract The cerebral blood flow (CBF) is tightly regulated by myogenic, endothelial, metabolic and neural mechanisms under physiological conditions, and a large body of recent evidence indicates that inflammatory pathways have a major influence on the cerebral blood […]

Comparisons of Δ9-tetrahydrocannabinol and Anandamide on a Battery of Cognition-related Behavior in Nonhuman Primates.

2016 Jan 29. pii: jpet.115.228189. [Epub ahead of print] Kangas BD1, Leonard MZ2, Shukla VG3, Alapafuja SO3, Nikas SP3, Makriyannis A3, Bergman J4. Author information Abstract The primary psychoactive ingredient of marijuana, Δ9-tetrahydrocannabinol (Δ9-THC), has medicinal value but also produces unwanted deleterious effects on cognitive function, promoting the search for improved cannabinergic therapeutics. The present studies used a battery of touchscreen […]

Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial.

2016 Jan 29. doi: 10.1111/dote.12455. [Epub ahead of print] Malik Z1, Bayman L2, Valestin J2, Rizvi-Toner A2, Hashmi S2, Schey R1,2. Author information Abstract Noncardiac chest pain is associated with poor quality of life and high care expenditure. The majority of noncardiac chest pain is either gastresophageal reflux disease related or due to esophageal motility disorders, and the rest are […]

Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers.

2016 Apr;11(4):1227-1230. Epub 2016 Jan 29. Zduniak K1, Ziółkowski P1, Regnell P2, Tollet-Egnell P3, Åkesson L4, Cooper ME2. Author information Abstract The primary aim of the present study was to determine the expression levels of cannabinoid receptor type 1 (CB1) in steatotic rat livers. The secondary aim was to clarify whether steatosis and inflammation are more marked in areas with increased CB1 […]

Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage.

2016 Jan 29;41(5-6):248-255. [Epub ahead of print] Di Napoli M1, Zha AM, Godoy DA, Masotti L, Schreuder FH, Popa-Wagner A, Behrouz R; from the MNEMONICH Registry. Author information Abstract OBJECTIVE: Recent evidence suggests that a potential harmful relationship exists between cannabis use and ischemic stroke. The purpose of this study was to determine the implications of cannabis use in intracerebral hemorrhage (ICH) […]