Archive | March, 2016

Endocannabinoid Signaling Regulates Sleep Stability.

 2016 Mar 31;11(3):e0152473. doi: 10.1371/journal.pone.0152473. Pava MJ1, Makriyannis A2, Lovinger DM1. Author information Abstract The hypnogenic properties of cannabis have been recognized for centuries, but endogenous cannabinoid (endocannabinoid) regulation of vigilance states is poorly characterized. We report findings from a series of experiments in mice measuring sleep with polysomnography after various systemic pharmacological manipulations of the endocannabinoid system. Rapid, […]

Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury.

2016 Mar 30. doi: 10.1002/jcp.25395. [Epub ahead of print] Wang L1, Yang L1, Tian L1, Mai P1, Jia S1, Yang L1, Li L1. Author information Abstract Cannabinoid receptors (CBs) have been implicated in the pathogenesis of various liver diseases, including liver fibrosis. Our previous studies have demonstrated that after liver injury, mouse bone marrow-derived mesenchymal stem cells (BMSCs) can migrate to the […]

Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.

2016 Mar 30;116:252-266. doi: 10.1016/j.ejmech.2016.03.072. [Epub ahead of print] Bertini S1, Chicca A2, Arena C3, Chicca S2, Saccomanni G4, Gertsch J2, Manera C4, Macchia M4. Author information Abstract Targeting type-2 cannabinoid receptor (CB2) is considered a feasible strategy to develop new drugs for the treatment of diseases like neuropathic pain, chronic inflammation, neurodegenerative disorders and cancer. Such drugs are devoid of the undesired central […]

The role of carbon monoxide on the anti-nociceptive effects and expression of cannabinoid 2 receptors during painful diabetic neuropathy in mice.

2016 Mar 29. [Epub ahead of print] Castany S1, Carcolé M1, Leánez S1, Pol O2. Author information Abstract RATIONALE: The activation of cannabinoid 2 receptors (CB2R) attenuates chronic pain, but the role played by carbon monoxide synthesized by the inducible heme oxygenase 1 (HO-1) on the anti-nociceptive effects produced by a selective CB2R agonist, JWH-015, during painful diabetic neuropathy remains […]

Mesoporous Silica Particles as a Multifunctional Delivery System for Pain Relief in Experimental Neuropathy.

2016 Mar 29. doi: 10.1002/adhm.201500996. [Epub ahead of print] Xie J1, Xiao D2,3, Zhao J1, Hu N1, Bao Q1, Jiang L1, Yu L4. Author information Abstract The long-term use of potent analgesics is often needed to treat chronic pain. However, it has been greatly hindered by their side effects such as addiction and withdrawal reactions. The study seeks to circumvent these […]

Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop.

2016 Mar 25:en20151384. [Epub ahead of print] Martella A1,2, Silvestri C2,3, Maradonna F1,4, Gioacchini G1,4, Allarà M2, Radaelli G5, Overby DR3, Di Marzo V2, Carnevali O1,4. Author information Abstract The xenoestrogen bisphenol A (BPA) is a widespread plasticizer detectable within several ecosystems. BPA is considered a metabolic disruptor affecting different organs; however, little is known about its mechanism of action in the liver, […]

Underbanked: Cooperative Banking as a Potential Solution to the Marijuana-Banking Problem.

2016;114(5):803-32. Tighe PA. Abstract Numerous states have recently legalized recreational marijuana, which has created a burgeoning marijuana industry needing and demanding access to a variety of banking and financial services. Due, however, to the interplay between the federal criminalization of marijuana and federal anti-money laundering laws, U.S. financial institutions cannot handle legally the proceeds from marijuana activity. […]

Prohedonic Effect of Cannabidiol in a Rat Model of Depression.

2016 Mar 25;73(2):123-129. [Epub ahead of print] Shoval G, Shbiro L, Hershkovitz L, Hazut N, Zalsman G, Mechoulam R, Weller A. Abstract BACKGROUND: Accumulating evidence suggests that cannabidiol (CBD) may be an effective and safe anxiolytic agent and potentially also an antidepressant. AIM: The objective of this study was to further examine these properties of CBD using the ‘depressive-like’ Wistar-Kyoto (WKY) rat, focusing […]

Use of cannabinoids in cancer care: palliative care

Curr Oncol. 2016 Mar; 23(2): S33–S36.  Published online 2016 Mar 16. doi:  10.3747/co.23.2962 PMCID: PMC4791145 S.K. Aggarwal, MD PhD* Author information ► Copyright and License information ► Go to: PALLIATIVE CARE IN ONCOLOGY All too often neglected, maximal quality improvement in the setting of life-limiting illness and noxious symptomatology is a worthy medical, public health, and humanitarian goal. The World Health […]