Archive | April, 2016

[Cannabinoid WIN55, 212-2 inhibits proliferation, invasion and migration of human SMMC-7721 hepatocellular carcinoma cells].

2016 May;32(5):619-24. [Article in Chinese] Wang J1, Deng Y1, Tan Y1, Li K2, Wen B2, Zhao Q3. Author information Abstract Objective To investigate the effects of WIN55, 212-2 (WIN) on the proliferation, invasion and migration of SMMC-7721 hepatocellular carcinoma cells and its underlying mechanisms. Methods SMMC-7721 cells were treated with (0, 1, 5, 10, 20) μmol/L WIN, and cell viability […]

Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor.

2016 Apr 29. [Epub ahead of print] Zou Z1, Lu Y1,2, Zha Y3, Yang H4,5. Author information Abstract Inflammation plays a pivotal role in the pathogenesis of many diseases in the central nervous system. Caudate nucleus (CN), the largest nucleus in the brain, is also implicated in many neurological disorders. 2-Arachidonoylglycerol (2-AG), the most abundant endogenous cannabinoid, has been […]

Opinions of Hospital Pharmacists in Canada Regarding Marijuana for Medical Purposes.

 2016 Mar-Apr;69(2):122-130. Epub 2016 Apr 29. Mitchell F1, Gould O2, LeBlanc M3, Manuel L4. Author information Abstract in English, French BACKGROUND: Canada’s most recent Marihuana for Medical Purposes Regulations have changed the way in which patients access marijuana. Furthermore, if authorized by the person in charge of the hospital, a pharmacist practising in a hospital may now place orders with licensed […]

Production of 10R-hydroxy unsaturated fatty acids from hempseed oil hydrolyzate by recombinant Escherichia coli cells expressing PpoC from Aspergillus nidulans.

2016 Apr 29. [Epub ahead of print] Han JE1, Seo MJ1, Shin KC1, Oh DK2. Author information Abstract The first and second preferred substrates of recombinant Escherichia coli cells expressing 10R-dioxygenase (PpoC) from Aspergillus nidulans and the purified enzyme were linoleic acid and α-linolenic acid, respectively. PpoC in cells showed higher thermal and reaction stabilities compared to purified […]

Driving the need to feed: Insight into the collaborative interaction between ghrelin and endocannabinoid systems in modulating brain reward systems.

2016 Apr 29;66:33-53. doi: 10.1016/j.neubiorev.2016.03.032. [Epub ahead of print] Edwards A1, Abizaid A2. Author information Abstract Independent stimulation of either the ghrelin or endocannabinoid system promotes food intake and increases adiposity. Given the similar distribution of their receptors in feeding associated brain regions and organs involved in metabolism, it is not surprising that evidence of their […]

Systemic and spinal administration of FAAH, MAGL inhibitors and dual FAAH/MAGL inhibitors produce antipruritic effect in mice.

2016 Apr 28. [Epub ahead of print] Yesilyurt O1, Cayirli M2, Sakin YS3, Seyrek M4, Akar A5, Dogrul A4. Author information Abstract The increase of endocannabinoid tonus by inhibiting fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL) represents a promising therapeutic approach in a variety of disease to overcome serious central side effects of exocannabinoids. Recent studies reported that systemic administration […]

Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus.

2016 Apr 28. pii: S0896-6273(16)30025-3. doi: 10.1016/j.neuron.2016.03.034. [Epub ahead of print] Stempel AV1, Stumpf A2, Zhang HY3, Özdoğan T2, Pannasch U2, Theis AK2, Otte DM4, Wojtalla A4, Rácz I4, Ponomarenko A5, Xi ZX3, Zimmer A4, Schmitz D6. Author information Abstract Endocannabinoids (eCBs) exert major control over neuronal activity by activating cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to the well-documented retrograde activation of presynaptic […]

Getting into the weed: the role of the endocannabinoid system in the brain-gut axis.

 2016 Apr 28. pii: S0016-5085(16)34319-0. doi: 10.1053/j.gastro.2016.04.015. [Epub ahead of print] Sharkey KA1, Wiley JW2. Author information Abstract The actions of cannabis are mediated by receptors that are part of an endogenous cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring ligands N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), their biosynthetic and degradative enzymes, and the cannabinoid receptors CB1 and […]

On a downer

The United Nations has chosen to keep the war on drugs going — but it can’t win. 27 April 2016 Article tools PDF Rights & Permissions Readers of the Los Angeles Times last week received some unexpected news about a major shift in the attitude of the United Nations towards the decriminalization of cannabis. According to the […]

Synthesis of (-)-Cannabimovone and Structural Reassignment of Anhydrocannabimovone through Gold(I)-Catalyzed Cycloisomerization.

2016 Apr 27. doi: 10.1002/anie.201601834. [Epub ahead of print] Carreras J1, Kirillova MS1, Echavarren AM2,3. Author information Abstract The first total synthesis of cannabimovone from Cannabis sativa and anhydrocannabimovone was achieved by means of a highly stereoselective gold(I)-catalyzed cycloisomerization. The results led to reassignment of the structure of anhydrocannabimovone. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, […]