Archive | June, 2016

Does cannabidiol have a role in the treatment of schizophrenia?

 2016 Jun 30. pii: S0920-9964(16)30289-4. doi: 10.1016/j.schres.2016.06.022. [Epub ahead of print] Gururajan A1, Malone DT2. Author information Abstract Schizophrenia is a debilitating psychiatric disorder which places a significant emotional and economic strain on the individual and society-at-large. Unfortunately, currently available therapeutic strategies do not provide adequate relief and some patients are treatment-resistant. In this regard, cannabidiol (CBD), a […]

Two affinity sites of cannabinoid CB2 receptor identified by a novel homogeneous binding assay.

2016 Jun 29. pii: jpet.116.234948. [Epub ahead of print] Martinez-Pinilla E1, Rabal O2, Reyes-Resina I3, Zamarbide M2, Navarro G3, Sanchez-Arias JA2, de Miguel I2, Lanciego JL2, Oyarzabal J2, Franco R3. Author information Abstract Cannabinoid receptors are G-protein-coupled receptors with potential in a variety of diseases. There are two different cannabinoid receptors types; ligands for type 2 (CB2R) show more promise than those for type […]

Microglia activation states and cannabinoid system: Therapeutic implications.

2016 Jun 29. pii: S0163-7258(16)30101-2. doi: 10.1016/j.pharmthera.2016.06.011. [Epub ahead of print] Mecha M1, Carrillo-Salinas FJ2, Feliú A2, Mestre L2, Guaza C3. Author information Abstract Microglial cells are recognized as the brain’s intrinsic immune cells, mediating actions that range from the protection against harmful conditions that modify CNS homeostasis, to the control of proliferation and differentiation of neurons and their […]

Cannabinoid receptors in the kidney.

2016 Jun 29. [Epub ahead of print] Hryciw DH1, McAinch AJ. Author information Abstract PURPOSE OF REVIEW: The endocannabinoid system modulates cell signaling targets that are essential for energy homeostasis. Endocannabinoids bind to G protein-coupled receptors in the central nervous system and periphery, including the kidney. Modulation of cannabinoid receptor 1 (CB1) and CB2 activity in the kidney […]

Expression of the endocannabinoid receptors in human fascial tissue.

2016 Jun 28;60(2):2643. doi: 10.4081/ejh.2016.2643. Fede C1, Albertin G, Petrelli L, Sfriso MM, Biz C, De Caro R, Stecco C. Author information Abstract Cannabinoid receptors have been localized in the central and peripheral nervous system as well as on cells of the immune system, but recent studies on animal tissue gave evidence for the presence of cannabinoid receptors in different types of tissues. Their […]

Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature.

2016 Jun 28;7:187. doi: 10.3389/fphar.2016.00187. eCollection 2016. Wills KL1, Parker LA1. Author information Abstract Over the years, animal studies have revealed a role for the endocannabinoid system in the regulation of multiple aspects of opiate addiction. The current review provides an overview of this literature in regards to opiate withdrawal. The opiate withdrawal syndrome, hypothesized to […]

The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation.

2016 Jun 28;8:17-39. doi: 10.4137/PMC.S32171. eCollection 2016. Bow EW1, Rimoldi JM1. Author information Abstract The cannabinoids are members of a deceptively simple class of terpenophenolic secondary metabolites isolated from Cannabis sativa highlighted by (-)-Δ(9)-tetrahydrocannabinol (THC), eliciting distinct pharmacological effects mediated largely by cannabinoid receptor (CB1 or CB2) signaling. Since the initial discovery of THC and related cannabinoids, synthetic and […]

Δ9-Tetrahydrocannabinolic acid synthase: the application of a plant secondary metabolite enzyme in biocatalytic chemical synthesis.

2016 Jun 28. pii: S0168-1656(16)31365-7. doi: 10.1016/j.jbiotec.2016.06.022. [Epub ahead of print] Lange K1, Schmid A2, Julsing MK3. Author information Abstract Δ9-Tetrahydrocannabinolic acid synthase (THCAS) from the secondary metabolism of Cannabis sativa L. catalyzes the oxidative formation of an intramolecular C-C bond in cannabigerolic acid (CBGA) to synthesize Δ9-tetrahydrocannabinolic acid (THCA), which is the direct precursor of Δ9-tetrahydrocannabinol […]

Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders.

2016 Jun 27. doi: 10.1002/ajmg.b.32467. [Epub ahead of print] Lester KJ1,2, Coleman JR2, Roberts S2, Keers R2, Breen G2,3, Bögels S4, Creswell C5, Hudson JL6, McKinnon A6,7,8, Nauta M9, Rapee RM6, Schneider S10, Silverman WK11, Thastum M12, Waite P5, Wergeland GJ13, Eley TC2. Author information Abstract Extinction learning is an important mechanism in the successful psychological treatment of anxiety. Individual differences in response and relapse following Cognitive Behavior Therapy may in […]

Endocannabionoid System in Neurological Disorders.

2016 Jun 27. [Epub ahead of print] Bifulco M, Laezza C, Malfitano AM1. Author information Abstract BACKGROUND: Several studies support the evidence that the endocannabinoid system and cannabimimetic drugs might have therapeutic potential in numerous pathologies. These pathologies range from neurological disorders, atherosclerosis, stroke, cancer to obesity/metabolic syndrome and others. METHODS: In this paper we review the […]