Archive | July, 2016

Effective treatment of spasticity using dronabinol in pediatric palliative care.

2016 Jul 30. pii: S1090-3798(16)30127-1. doi: 10.1016/j.ejpn.2016.07.021. [Epub ahead of print] Kuhlen M1, Hoell JI2, Gagnon G2, Balzer S2, Oommen PT2, Borkhardt A2, Janßen G2. Author information Abstract BACKGROUND: Cannabis extracts have a wide therapeutic potential but in many countries they have not been approved for treatment in children so far. OBJECTIVE: We conducted an open, uncontrolled, retrospective study on the administration of […]

Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17-dependent mechanism.

2016 Jul 29. pii: jbc.M116.746594. [Epub ahead of print] Alferink J1, Specht S2, Arends H3, Schumak B3, Schmidt K2, Ruland C4, Lundt R3, Kemter A3, Dlugos A4, Kuepper JM2, Poppensieker K3, Findeiß M3, Albayram Ö3, Otte DM3, Marazzi J5, Gertsch J5, Förster I3, Maier W2, Scheu S6, Hoerauf A2, Zimmer A3. Author information Abstract Cerebral malaria (CM) is a severe and often fatal complication of Plasmodium falciparum infection. It is characterized by parasite sequestration, a […]

A Belated Green Revolution for Cannabis: Virtual Genetic Resources to Fast-Track Cultivar Development.

Front Plant Sci. 2016; 7: 1113.  Published online 2016 Jul 29. doi:  10.3389/fpls.2016.01113 PMCID: PMC4965456 Matthew T. Welling,1 Tim Shapter,1,2 Terry J. Rose,1 Lei Liu,1 Rhia Stanger,1 and  Graham J. King1,* Author information ► Article notes ► Copyright and License information ► Go to: Abstract Cannabis is a predominantly diecious phenotypically diverse domesticated genus with few if any extant natural populations. International narcotics conventions and associated legislation have constrained the […]

Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice.

 2016 Jul 29. pii: S1074-7427(16)30130-7. doi: 10.1016/j.nlm.2016.07.030. [Epub ahead of print] Zhang RS1, He Z1, Jin WD1, Wang R2. Author information Abstract The cannabinoid system plays an important role in memory processes, many studies have indicated that cannabinoid receptor ligands have ability to modulate memory in rodents. A nonapeptide hemopressin (Hp) derived from rat brain, acts as a peptide antagonist or selective […]

Advances in the Physiology of GPR55 in the Central Nervous System.

2016 Jul 29. [Epub ahead of print] Marichal-Cancino BA1, Fajardo-Valdéz A, Ruiz-Contreras AE, Méndez-Díaz M, Prospéro-García O. Author information Abstract The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor whose functions in the central nervous system (CNS) have been scarcely elucidated. Several endogenous lipids (cannabinoids and non-cannabinoid) may activate GPR55; these facts have raised a discussion about its nature as […]

The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer’s disease.

 2016 Jul 28. [Epub ahead of print] Karl T1, Garner B, Cheng D. Author information Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder, characterized by progressive loss of cognition. Over 35 million individuals currently have AD worldwide. Unfortunately, current therapies are limited to very modest symptomatic relief. The brains of AD patients are characterized by […]

Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation.

2016 Jul 28. [Epub ahead of print] Yang F1, Xu Q, Shu B, Tiwari V, He SQ, Vera-Portocarrero LP, Dong X, Linderoth B, Raja SN, Wang Y, Guan Y. Author information Abstract Activation of Aβ-fibers is an intrinsic feature of spinal cord stimulation (SCS) pain therapy. Cannabinoid receptor type 1 (CB1) is important to neuronal plasticity and pain modulation, but its role in SCS-induced pain inhibition remains […]

A role for the endocannabinoid system in premature luteal regression and progesterone withdrawal in lipopolysaccharide-induced early pregnancy loss model.

2016 Jul 28. pii: gaw050. [Epub ahead of print] Schander JA1, Correa F1, Bariani MV1, Blanco J1, Cymeryng C2, Jensen F3, Wolfson ML4, Franchi AM1. Author information Abstract STUDY QUESTION: What is the role of the endocannabinoid system (eCS) in the alterations of the endocrine system in a murine model of lipopolysaccharide (LPS)-induced miscarriage? SUMMARY ANSWER: In 7-days pregnant wild type, but […]

Proteomics of terpenoid biosynthesis and secretion in trichomes of higher plant species.

 2016 Aug;1864(8):1039-49. doi: 10.1016/j.bbapap.2016.02.010. Epub 2016 Feb 9. Champagne A1, Boutry M2. Author information Abstract Among the specialized (secondary) plant metabolites, terpenoids represent the most diverse family and are often involved in the defense against pathogens and herbivores. Terpenoids can be produced both constitutively and in response to the environment. At the front line of this […]

Treatment with the GPR55 antagonist CID16020046 increases neutrophil activation in mouse atherogenesis.

 2016 Jul 28;116(5). [Epub ahead of print] Montecucco F1, Bondarenko AI, Lenglet S, Burger F, Piscitelli F, Carbone F, Roth A, Liberale L, Dallegri F, Brandt KJ, Fraga-Silva RA, Stergiopulos N, Di Marzo V, Mach F. Author information Abstract Endocannabinoids modulate atherogenesis by triggering different receptors. Recently, orphan G protein-coupled receptors (GPRs) were suggested to be activated by endocannabinoids, possibly regulating vasorelaxation. Here, we investigated whether GPR55 antagonism with CID16020046 […]