Archive | November, 2016

Lifelong imbalanced linoleic/alpha-linolenic acid intake impairs emotional and cognitive behavior in adult rats via changes in brain endocannabinoid system.

J Lipid Res. 2016 Nov 30. pii: jlr.M068387. [Epub ahead of print] Zamberletti E1, Piscitelli F2, De Castro V3, Murru E4, Gabaglio M1, Colucci P3, Fanali C5, Prini P1, Bisogno T6, Maccarrone M7, Campolongo P3, Banni S4, Rubino T1, Parolaro D8. Author information Abstract Imbalanced dietary n-3 and n-6 PUFA content has been associated with a number of neurological conditions. Endocannabinoids are n-6 PUFA derivatives, whose brain concentrations are sensitive to […]

Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission.

Brain Struct Funct. 2016 Nov 30. [Epub ahead of print] Lee SH1,2, Dudok B3,4, Parihar VK5, Jung KM6, Zöldi M3,4, Kang YJ7, Maroso M6,8, Alexander AL8, Nelson GA9, Piomelli D6, Katona I3, Limoli CL5, Soltesz I8. Author information Abstract In the not too distant future, humankind will embark on one of its greatest adventures, the travel to distant planets. However, deep space travel is associated with an inevitable […]

Ocular Disposition of ∆8-Tetrahydrocannabinol from Various Topical Ophthalmic Formulations.

AAPS PharmSciTech. 2016 Nov 30. [Epub ahead of print] Punyamurthula NS1, Adelli GR1, Gul W2, Repka MA1,3, ElSohly MA1,2,3, Majumdar S4,5. Author information Abstract The purposes of this project are to enhance the trans-membrane penetration of Δ8-Tetrahydrocannabinol(Δ8-THC) and to study the effect of various lipid based systems in delivering the compound, non-invasively, to anterior and posterior ocular chambers. Solid lipid nanoparticles […]

Tasty THC: Promises and Challenges of Cannabis Edibles.

Methods Rep RTI Press. 2016 Nov;2016. doi: 10.3768/rtipress.2016.op.0035.1611. Barrus DG1, Capogrossi KL1, Cates SC1, Gourdet CK1, Peiper NC1, Novak SP1, Lefever TW1, Wiley JL1. Author information Abstract Food products containing cannabis extract (edibles) have emerged as a popular and lucrative facet of the legalized market for both recreational and medicinal cannabis. The many formulations of cannabis extracts used in edibles present a unique regulatory challenge for policy makers. Though […]

Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome After Stroke.

Stroke. 2016 Nov 29. pii: STROKEAHA.116.014793. [Epub ahead of print] Bravo-Ferrer I1, Cuartero MI1, Zarruk JG1, Pradillo JM1, Hurtado O1, Romera VG1, Díaz-Alonso J1, García-Segura JM1, Guzmán M1, Lizasoain I1, Galve-Roperh I1, Moro MA2. Author information Abstract BACKGROUND AND PURPOSE: Stroke is a leading cause of adult disability characterized by physical, cognitive, and emotional disturbances. Unfortunately, pharmacological options are scarce. The cannabinoid type-2 receptor (CB2R) is neuroprotective in acute […]

Alcohol and cannabis: Comparing their adverse health effects and regulatory regimes.

Int J Drug Policy. 2016 Nov 28. pii: S0955-3959(16)30334-6. doi: 10.1016/j.drugpo.2016.10.021. [Epub ahead of print] Hall W1. Author information Abstract The claim that the adverse health effects of cannabis are much less serious than those of alcohol has been central to the case for cannabis legalisation. Regulators in US states that have legalised cannabishave adopted regulatory models based on alcohol. This paper critically […]

[Textual research on Han-Chinese formulae collected in Tubo medical manuscript unearthed in ‘Bum-pa-Che Tower].

Zhonghua Yi Shi Za Zhi. 2016 Nov 28;46(6):359-362. doi: 10.3760/cma.j.issn.0255-7053.2016.06.008. [Article in Chinese; Abstract available in Chinese from the publisher] Liu YH1, Nong HC2. Author information Abstract in English, Chinese A Tibetan manuscript with title of Sman–dpyad gces–pa grub–pa kun-‘dus–pa in the Collection of Practiced MedicalQuintessence, was found in the basement of a Buddhist tower named ‘Bum–pa–che in Lhokha (Shannan), Tibet. It contains a […]

Human presynaptic receptors.

Pharmacol Ther. 2016 Nov 27. pii: S0163-7258(16)30231-5. doi: 10.1016/j.pharmthera.2016.11.005. [Epub ahead of print] Schlicker E1, Feuerstein T2. Author information Abstract Presynaptic receptors are sites at which transmitters, locally formed mediators or hormones inhibit or facilitate the release of a given transmitter from its axon terminals. The interest in the identification of presynaptic receptors has faded in recent […]

Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation?

Br J Pharmacol. 2016 Nov 27. doi: 10.1111/bph.13676. [Epub ahead of print] Gertsch J1. Author information Abstract The endocannabinoid system (ECS) is a major lipid signaling network that plays important pro-homeostatic (allostatic) roles not only in the nervous system but in peripheral organs. Increasing evidence points towards a dietary component in the modulation of the ECS. Cannabinoid receptors […]

Understanding and learning from the diversification of cannabis supply laws.

Addiction. 2016 Nov 27. doi: 10.1111/add.13623. [Epub ahead of print] Kilmer B1, Pacula RL1. Author information Abstract BACKGROUND AND AIMS: Prohibitions on producing, distributing and selling cannabis are loosening in various jurisdictions around the world. This paper describes the diversification of cannabis supply laws and discusses the challenges to and opportunities for learning from these changes. METHODS: We document changes in cannabis supply […]