Archive | December, 2016

Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons.

Redox Biol. 2016 Dec 31;11:577-585. doi: 10.1016/j.redox.2016.12.029. [Epub ahead of print] Sun S1, Hu F1, Wu J2, Zhang S3. Author information Abstract Deficient bioenergetics and diminished redox conservation have been implicated in the development of cerebral ischemia/reperfusion injury. In this study, the mechanisms underlying the neuroprotective effects of cannabidiol (CBD), a nonpsychotropic compound derived from Cannabis sativa with FDA-approved antiepilepsy properties, […]

Interactions between cannabidiol and Δ9-THC following acute and repeated dosing: Rebound hyperactivity, sensorimotor gating and epigenetic and neuroadaptive changes in the mesolimbic pathway.

Eur Neuropsychopharmacol. 2016 Dec 30. pii: S0924-977X(16)32012-0. doi: 10.1016/j.euroneuro.2016.12.004. [Epub ahead of print] Todd SM1, Zhou C1, Clarke DJ1, Chohan TW1, Bahceci D2, Arnold JC3. Author information Abstract The evidence base for the use of medical cannabis preparations containing specific ratios of cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) is limited. While there is abundant data on acute interactions between CBD and THC, […]

The Effect of Medicinal Cannabis on Pain and Quality-of-Life Outcomes in Chronic Pain: A Prospective Open-label Study.

Clin J Pain. 2016 Dec;32(12):1036-1043. Haroutounian S1, Ratz Y, Ginosar Y, Furmanov K, Saifi F, Meidan R, Davidson E. Author information Abstract OBJECTIVES: The objective of this prospective, open-label study was to determine the long-term effect of medicinal cannabis treatment on pain and functional outcomes in participants with treatment-resistant chronic pain. PATIENTS AND METHODS: The […]

Plasma endocannabinoid behaviour in total knee and hip arthroplasty.

J Biol Regul Homeost Agents. 2016 Oct-Dec;30(4):1147-1152. Ottria R1, Cappelletti L2, Ravelli A3, Mariotti M3,4, Gigli F3, Romagnoli S5, Ciuffreda P1, Banfi G6, Drago L2,7. Author information Abstract Endocannabinoids are a class of lipid mediators involved in a wide range of physiological pathways including pain perception, and immunological defences. In particular, the involvement of endocannabinoids in bone metabolism and bone resorption has recently been studied. Moreover, one […]

Cannabinoids – a new weapon against cancer?

Postepy Hig Med Dosw (Online). 2016 Dec 29;70(0):1309-1320. doi: 10.5604/17322693.1227443. Pokrywka M1, Góralska J1, Solnica B1. Author information Abstract Cannabis has been cultivated by man since Neolithic times. It was used, among others for fiber and rope production, recreational purposes and as an excellent therapeutic agent. The isolation and characterization of the structure of one of the main […]

Protective effects of trans-caryophyllene on maintaining osteoblast function.

IUBMB Life. 2017 Jan;69(1):22-29. doi: 10.1002/iub.1584. Shan J1, Chen L1, Lu K1. Author information Abstract Age-related osteoblast dysfunction is the main cause of age-related bone loss. Trans-caryophyllene (TC) is an important constituent of the essential oils derived from several species of medicinal plants. In this study, we investigated the effects of TC on osteoblast function in osteoblastic MC3T3-E1 […]

Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes.

Physiol Behav. 2016 Dec 22. pii: S0031-9384(16)30716-8. doi: 10.1016/j.physbeh.2016.11.041. [Epub ahead of print] Thompson Z1, Argueta D2, Garland T Jr3, DiPatrizio N2. Author information Abstract The endocannabinoid system serves many physiological roles, including in the regulation of energy balance, food reward, and voluntary locomotion. Signaling at the cannabinoid type 1 receptor has been specifically implicated in motivation for rodent […]

Mitochondrial functions of THP-1 monocytes following the exposure to selected natural compounds.

Toxicology. 2016 Dec 21. pii: S0300-483X(16)30338-9. doi: 10.1016/j.tox.2016.12.006. [Epub ahead of print] Schultze N1, Wanka H2, Zwicker P3, Lindequist U3, Haertel B3. Author information Abstract The immune system is an important target of various xenobiotics, which may lead to severe adverse effects including immunosuppression or inappropriate immunostimulation. Mitochondrial toxicity is one possibility by which xenobiotics exert their toxic effects in […]

Development of new inhibitors for N-acylethanolamine-hydrolyzing acid amidase as promising tool against bladder cancer.

Bioorg Med Chem. 2016 Dec 27. pii: S0968-0896(16)31496-1. doi: 10.1016/j.bmc.2016.12.042. [Epub ahead of print] Vago R1, Bettiga A2, Salonia A3, Ciuffreda P4, Ottria R5. Author information Abstract The endocannabinoid system is a signaling system involved in a wide range of biological effects. Literature strongly suggests the endocannabinoid system role in the pathogenesis of cancer and that its pharmacological activation produces therapeutic benefits. Last research […]

Cannabis, Tobacco, Alcohol Use, and the Risk of Early Stroke: A Population-Based Cohort Study of 45 000 Swedish Men.

Stroke. 2016 Dec 27. pii: STROKEAHA.116.015565. doi: 10.1161/STROKEAHA.116.015565. [Epub ahead of print] Falkstedt D1, Wolff V1, Allebeck P1, Hemmingsson T1, Danielsson AK2. Author information Abstract BACKGROUND AND PURPOSE: Current knowledge on cannabis use in relation to stroke is based almost exclusively on clinical reports. By using a population-based cohort, we aimed to find out whether there was an association between cannabis use and early-onset […]