Archive | February, 2017

Changes in the Brain Endocannabinoid System in Rat Models of Depression.

Neurotox Res. 2017 Feb 28. doi: 10.1007/s12640-017-9708-y. [Epub ahead of print] Smaga I1,2, Jastrzębska J2, Zaniewska M2, Bystrowska B1, Gawliński D2, Faron-Górecka A3, Broniowska Ż1, Miszkiel J2, Filip M4,5. Author information Abstract A growing body of evidence implicates the endocannabinoid (eCB) system in the pathophysiology of depression. The aim of this study was to investigate the influence of changes in the eCB system, such as levels […]

MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future.

Eur J Endocrinol. 2017 Feb 28. pii: EJE-16-1044. doi: 10.1530/EJE-16-1044. [Epub ahead of print] Simon V1, Cota D2. Author information Abstract The endocannabinoid system (ECS), including cannabinoid type 1 and type 2 receptors (CB1R and CB2R), endogenous ligands called endocannabinoids and their related enzymatic machinery, is known to have a role in the regulation of energy balance. Past information generated on the ECS, […]

Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others?

Expert Rev Clin Pharmacol. 2017 Feb 28:1-13. doi: 10.1080/17512433.2017.1292849. [Epub ahead of print] Maccarrone M1,2, Maldonado R3, Casas M4,5,6, Henze T7, Centonze D8. Author information Abstract INTRODUCTION: The complexity of the endocannabinoid (eCB) system is becoming better understood and new drivers of eCB signaling are emerging. Modulation of the activities of the eCB system can be therapeutic in a number […]

Cannabinoids as gastrointestinal anti-inflammatory drugs.

Neurogastroenterol Motil. 2017 Mar;29(3). doi: 10.1111/nmo.13038. Fabisiak A1, Fichna J1. Author information Abstract In this mini-review, we focus on the potential of the endocannabinoid system as a target for novel therapies to treat gastrointestinal (GI) inflammation. We discuss the organization of the endocannabinoid signaling and present possible pharmacological sites in the endocannabinoid system. We also refer to […]

Flexible Bionanocomposites from Epoxidised Hemp Seed Oil Thermosetting Resin Reinforced with Halloysite Nanotubes.

J Phys Chem B. 2017 Feb 27. doi: 10.1021/acs.jpcb.7b00103. [Epub ahead of print] Shuttleworth PS, Díez-Pascual AM, Marco C, Ellis G. Abstract Hempseed (Cannabis sativa L.) oil comprises a variety of beneficial unsaturated triglycerides with well-documented nutritional and health benefits. However, it can become rancid over a relatively short time period leading to increased industrial costs and waste of a […]

Cannabidiol Affects MK-801-Induced Changes in the PPI Learned Response of Capuchin Monkeys (Sapajus spp.).

Front Pharmacol. 2017 Feb 27;8:93. doi: 10.3389/fphar.2017.00093. eCollection 2017. Saletti PG1, Maior RS2, Barros M3, Nishijo H4, Tomaz C5. Author information Abstract There are several lines of evidence indicating a possible therapeutic action of cannabidiol (CBD) in schizophrenia treatment. Studies with rodents have demonstrated that CBD reverses MK-801 effects in prepulse inhibition (PPI) disruption, which may indicate that CBD acts by improving […]

Oleoylethanolamide: A fat ally in the fight against obesity.

Physiol Behav. 2017 Feb 27. pii: S0031-9384(16)31199-4. doi: 10.1016/j.physbeh.2017.02.034. [Epub ahead of print] Brown JD1, Azari EK2, Ayala JE2. Author information Abstract Obesity is a pandemic, gateway disease that has thrived in modern, sedentary, high calorie-eating societies. Left unchecked, obesity and obesity-related diseases will continue to plague future generations with heavy burdens on economies, healthcare systems, and the […]

The Direct Actions of Cannabidiol and 2-Arachidonoyl Glycerol at GABAA Receptors.

Pharmacol Res. 2017 Feb 26. pii: S1043-6618(16)31139-2. doi: 10.1016/j.phrs.2017.02.022. [Epub ahead of print] Bakas T1, van Nieuwenhuijzen PS1, Devenish SO2, McGregor IS3, Arnold JC4, Chebib M5. Author information Abstract Cannabidiol (CBD) is a major non-intoxicating component of cannabis and possesses anti-epileptic, anxiolytic and anti-hyperalgesic properties. The mechanism of action of CBD in producing such effects remains unclear. Despite evidence that some […]

Nutritional status dependent endocannabinoid signalling regulates the integration of rat visceral information.

J Physiol. 2017 Feb 24. doi: 10.1113/JP273484. [Epub ahead of print] Khlaifia A1, Matias I2,3, Cota D2,3, Tell F1. Author information Abstract Communication form the viscera to the brain is essential to set physiological homoeostatic parameters but also to drive more complex behaviours such as mood, memory and emotional states. Here we investigated the impact of the nutritional status […]

Concise review of the management of iatrogenic emesis using cannabinoids: emphasis on nabilone for chemotherapy-induced nausea and vomiting.

Cancer Chemother Pharmacol. 2017 Feb 24. doi: 10.1007/s00280-017-3257-1. [Epub ahead of print] Pergolizzi JV Jr1, Taylor R1, LeQuang JA2, Zampogna G1, Raffa RB3. Author information Abstract Chemotherapy-induced nausea and vomiting (CINV) is a prevalent, distressing, and burdensome side effect of cancer chemotherapy. It is estimated to affect the majority of patients receiving certain anti-cancer drug regimens and can be treatment-limiting, […]