Archive | March, 2017

Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS.

Neuropharmacology. 2017 Mar 31. pii: S0028-3908(17)30129-6. doi: 10.1016/j.neuropharm.2017.03.037. [Epub ahead of print] Pasquarelli N1, Engelskirchen M2, Hanselmann J2, Endres S2, Porazik C1, Bayer H2, Buck E2, Karsak M3, Weydt P4, Ferger B5, Witting A2. Author information Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron system with limited therapeutic options. […]

Post-sensitization treatment with rimonabant blocks the expression of cocaine-induced behavioral sensitization and c-Fos protein in mice.

Pharmacol Biochem Behav. 2017 Mar 30. pii: S0091-3057(17)30199-5. doi: 10.1016/j.pbb.2017.03.006. [Epub ahead of print] Marinho EA1, Oliveira Lima AJ2, Yokoyama TS3, Santos-Baldaia R3, Ribeiro LT4, Baldaia MA4, da Silva RW3, Hollais AW3, Talhati F4, Longo BM3, Berro LF5, Frussa-Filho R6. Author information Abstract CB1 receptor antagonists have been shown to prevent acute and long-term behavioral […]

A natural product from Cannabis sativa subsp. sativa inhibits homeodomain-interacting protein kinase 2 (HIPK2), attenuating MPP+-induced apoptosis in human neuroblastoma SH-SY5Y cells.

Bioorg Chem. 2017 Mar 30;72:64-73. doi: 10.1016/j.bioorg.2017.03.011. [Epub ahead of print] Wang G1, Zhu L1, Zhao Y1, Gao S1, Sun D1, Yuan J2, Huang Y1, Zhang X3, Yao X4. Author information Abstract Homeodomain-interacting protein kinase 2 (HIPK2) is a conserved serine/threonine kinase, which regulate transcription, cell differentiation, proliferation and apoptosis. Previous evidences indicated that HIPK2 […]

A practical framework for regulating for-profit recreational marijuana in US States: Lessons from Colorado and Washington.

Int J Drug Policy. 2017 Mar 30. pii: S0955-3959(17)30066-X. doi: 10.1016/j.drugpo.2017.03.001. [Epub ahead of print] Carnevale JT1, Kagan R2, Murphy PJ3, Esrick J2. Author information Abstract Despite the federal prohibition against marijuana, state-level recreational use appears to be moving forward. Public opinion is shifting. Following well-publicized state-legalization in Washington and Colorado, states across the US […]

Cannabis, Cannabinoids, and Sleep: a Review of the Literature.

Curr Psychiatry Rep. 2017 Apr;19(4):23. doi: 10.1007/s11920-017-0775-9. Babson KA1, Sottile J2, Morabito D3. Author information Abstract PURPOSE OF REVIEW: The current review aims to summarize the state of research on cannabis and sleep up to 2014 and to review in detail the literature on cannabis and specific sleep disorders from 2014 to the time of […]

Carbonyl Compounds Produced by Vaporizing Cannabis Oil Thinning Agents.

J Altern Complement Med. 2017 Mar 29. doi: 10.1089/acm.2016.0337. [Epub ahead of print] Troutt WD1, DiDonato MD1. Author information Abstract OBJECTIVE: Cannabis use has increased in the United States, particularly the use of vaporized cannabis oil, which is often mixed with thinning agents for use in vaporizing devices. E-cigarette research shows that heated thinning agents […]

Terpene synthases from Cannabis sativa.

PLoS One. 2017 Mar 29;12(3):e0173911. doi: 10.1371/journal.pone.0173911. eCollection 2017. Booth JK1, Page JE2,3, Bohlmann J1,3. Author information Abstract Cannabis (Cannabis sativa) plants produce and accumulate a terpene-rich resin in glandular trichomes, which are abundant on the surface of the female inflorescence. Bouquets of different monoterpenes and sesquiterpenes are important components of cannabis resin as they define […]

Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds.

Int J Mol Sci. 2017 Mar 28;18(4). pii: E709. doi: 10.3390/ijms18040709. Conte R1, Marturano V2,3, Peluso G4, Calarco A5, Cerruti P6. Author information Abstract Phytocompounds have been used in medicine for decades owing to their potential in anti-inflammatory applications. However, major difficulties in achieving sustained delivery of phyto-based drugs are related to their low solubility […]

[Role of cannabinoid receptor 1-mediated synaptic plasticity in neuropathic pain and associated depression].

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Mar 28;42(3):340-345. doi: 10.11817/j.issn.1672-7347.2017.03.017. [Article in Chinese; Abstract available in Chinese from the publisher] Pan W1, Wang X2, Zhang G2, Yang J2. Author information Abstract in English, Chinese Neuropathic pain is a class of pain caused by an injury or diseases of the somatosensory system […]

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.

Nat Commun. 2017 Mar 28;8:14782. doi: 10.1038/ncomms14782. Bluett RJ1,2, Báldi R1, Haymer A1, Gaulden AD1, Hartley ND1,2, Parrish WP3, Baechle J1, Marcus DJ1,2, Mardam-Bey R1, Shonesy BC3, Uddin MJ4, Marnett LJ4,5, Mackie K6, Colbran RJ2,3,7,8, Winder DG1,2,3,7,8, Patel S1,2,3,7,8. Author information Abstract Stress is a ubiquitous risk factor for the exacerbation and development of affective […]