Archive | June, 2017

Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy?

J Epilepsy Res. 2017 Jun 30;7(1):16-20. doi: 10.14581/jer.17003. eCollection 2017 Jun. Koo CM1, Kang HC2. Author information Abstract Epilepsy is an important disease that affects brain function, particularly in those under 3 years old. Uncontrolled seizures can affect cognitive function and quality of life. For these reasons, many trials have been conducted to investigate treatments […]

Participation of hypothalamic CB1 receptors in reproductive axis disruption during immune challenge.

J Neuroendocrinol. 2017 Jun 30. doi: 10.1111/jne.12499. [Epub ahead of print] Surkin PN1,2, Di Rosso ME3, Correa F4, Elverdin JC1, Genaro AM3,5, De Laurentiis A4, Fernández-Solari J1,2. Author information Abstract It is known that immune challenge inhibits reproductive function and that endocannabinoids (eCB) modulate sexual hormones. However, no studies have been performed to assess whether […]

Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice.

Neuropharmacology. 2017 Jun 30. pii: S0028-3908(17)30305-2. doi: 10.1016/j.neuropharm.2017.06.032. [Epub ahead of print] Owens RA1, Mustafa MA1, Ignatowska-Jankowska BM1, Damaj MI2, Beardsley PM1, Wiley JL3, Niphakis MJ4, Cravatt BF4, Lichtman AH5. Author information Abstract Substantial challenges exist for investigating the cannabinoid receptor type 1 (CB1)-mediated discriminative stimulus effects of the endocannabinoids, 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide; […]

Activation of CaMKKβ/AMPKα pathway by 2-AG in human platelets.

J Cell Biochem. 2017 Jun 29. doi: 10.1002/jcb.26251. [Epub ahead of print] Signorello MG1, Leoncini G1. Author information Abstract The objective of this study was to determine whether AMPK is activated by 2-arachidonoylglycerol (2-AG) and participates to the cytoskeleton control in human platelets. We found that 2-AG stimulates the AMPKα activation through a Ca2+ /Calmodulin-dependent […]

AM1241 alleviates MPTP-induced Parkinson’s disease and promotes the regeneration of DA neurons in PD mice.

Oncotarget. 2017 Jun 29. doi: 10.18632/oncotarget.18871. [Epub ahead of print] Shi J1,2, Cai Q1, Zhang J1, He X1, Liu Y1, Zhu R1,3, Jin L1. Author information Abstract The main pathological feature of Parkinson’s disease (PD) is the loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the role of cannabinoid receptor […]

Characterizing marijuana concentrate users: A web-based survey.

Drug Alcohol Depend. 2017 Jun 29;178:399-407. doi: 10.1016/j.drugalcdep.2017.05.034. [Epub ahead of print] Daniulaityte R1, Lamy FR2, Barratt M3, Nahhas RW4, Martins SS5, Boyer EW6, Sheth A7, Carlson RG2. Author information Abstract AIMS: The study seeks to characterize marijuana concentrate users, describe reasons and patterns of use, perceived risk, and identify predictors of daily/near daily use. […]

Smoked marijuana attenuates performance and mood disruptions during simulated night shift work.

Drug Alcohol Depend. 2017 Jun 28;178:534-543. doi: 10.1016/j.drugalcdep.2017.04.036. [Epub ahead of print] Keith DR1, Gunderson EW2, Haney M2, Foltin RW2, Hart CL3. Author information Abstract Individuals who work nonstandard schedules, such as rotating or night shifts, are more susceptible to workplace injuries, performance decrements, and reduced productivity. This population is also almost twice as likely […]

Chemical Tools for Studying Lipid-Binding Class A G Protein-Coupled Receptors.

Pharmacol Rev. 2017 Jul;69(3):316-353. doi: 10.1124/pr.116.013243. Cooper A1, Singh S1, Hook S1, Tyndall JDA1, Vernall AJ2. Author information Abstract Cannabinoid, free fatty acid, lysophosphatidic acid, sphingosine 1-phosphate, prostanoid, leukotriene, bile acid, and platelet-activating factor receptor families are class A G protein-coupled receptors with endogenous lipid ligands. Pharmacological tools are crucial for studying these receptors and […]

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.

Front Pharmacol. 2017 Jun 28;8:422. doi: 10.3389/fphar.2017.00422. eCollection 2017. Morales P1, Reggio PH1, Jagerovic N2. Author information Abstract Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its beneficial neuroprotective, […]

Are dispensaries indispensable? Patient experiences of access to cannabis from medical cannabis dispensaries in Canada.

Int J Drug Policy. 2017 Jun 28;47:1-8. doi: 10.1016/j.drugpo.2017.05.046. [Epub ahead of print] Capler R1, Walsh Z2, Crosby K2, Belle-Isle L3, Holtzman S2, Lucas P4, Callaway R5. Author information Abstract BACKGROUND: In 2001, Canada established a federal program for cannabis for therapeutic purposes (CTP). Medical cannabis dispensaries (dispensaries) are widely accessed as a source of CTP […]