Archive | October, 2017

Cannabis in fat: high hopes to treat obesity.

J Clin Invest. 2017 Oct 16. pii: 97042. doi: 10.1172/JCI97042. [Epub ahead of print] Hawkins MN1,2, Horvath TL2,3. Author information Abstract Cannabinoid receptor type-1 (CB1s) is known to have a substantial impact on the regulation of energy metabolism via central and peripheral mechanisms. In this issue of the JCI, Ruiz de Azua and colleagues provide […]

Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.

J Clin Invest. 2017 Oct 16. pii: 83626. doi: 10.1172/JCI83626. [Epub ahead of print] Ruiz de Azua I1, Mancini G1, Srivastava RK1, Rey AA1, Cardinal P2,3, Tedesco L4, Zingaretti CM5, Sassmann A6, Quarta C7,8, Schwitter C1, Conrad A1, Wettschureck N6, Vemuri VK9, Makriyannis A9, Hartwig J10, Mendez-Lago M10, Bindila L1, Monory K1, Giordano A5, Cinti […]

Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy.

J Am Soc Nephrol. 2017 Oct 13. pii: ASN.2017040371. doi: 10.1681/ASN.2017040371. [Epub ahead of print] Hinden L1, Udi S1, Drori A1, Gammal A1, Nemirovski A1, Hadar R1, Baraghithy S1, Permyakova A1, Geron M2, Cohen M3,4, Tsytkin-Kirschenzweig S3,4, Riahi Y5, Leibowitz G5, Nahmias Y3,4, Priel A2, Tam J6. Author information Abstract Altered glucose reabsorption via the […]

Recreational Cannabis Legalization and Opioid-Related Deaths in Colorado, 2000-2015.

Am J Public Health. 2017 Nov;107(11):1827-1829. doi: 10.2105/AJPH.2017.304059. Livingston MD1, Barnett TE1, Delcher C1, Wagenaar AC1. Author information Abstract OBJECTIVES: To examine the association between Colorado’s legalization of recreational cannabis use and opioid-related deaths. METHODS: We used an interrupted time-series design (2000-2015) to compare changes in level and slope of monthly opioid-related deaths before and […]

Human bone marrow mesenchymal stem cells secrete endocannabinoids that stimulate in vitro hematopoietic stem cell migration effectively comparable to beta adrenergic stimulation.

Exp Hematol. 2017 Oct 10. pii: S0301-472X(17)30813-5. doi: 10.1016/j.exphem.2017.09.009. [Epub ahead of print] Köse S1, Aerts-Kaya F1, Köprü AZ2, Nemutlu E3, Kuşkonmaz B4, Karaosmanoğlu B1, Taşkıran ZE5, Altun B6, Uçkan Çetinkaya D7, Korkusuz P8. Author information Abstract Granulocyte Colony-Stimulating Factor (G-CSF) is a well-known hematopoietic stem cell (HSC) mobilizing agent used in both allogeneic and […]

Effects of cannabinoid receptor type 2 in respiratory syncytial virus infection in human subjects and mice.

Virulence. 2017 Oct 9:0. doi: 10.1080/21505594.2017.1389369. [Epub ahead of print] Tahamtan A1, Samieipoor Y1, Nayeri FS2, Rahbarimanesh AA3, Izadi A3, Rashidi-Nezhad A4, Tavakoli-Yaraki M5, Farahmand M1, Bont L6, Shokri F7, Mokhatri-Azad T1, Salimi V1. Author information Abstract An accumulating body of evidence suggests that the endocannabinoid system plays a significant role in pathophysiological processes and […]

Cannabinoid receptor 2 as a novel target for promotion of renal cell carcinoma prognosis and progression.

J Cancer Res Clin Oncol. 2017 Oct 9. doi: 10.1007/s00432-017-2527-y. [Epub ahead of print] Wang J1, Xu Y1, Zhu L1, Zou Y1, Kong W1, Dong B1, Huang J1, Chen Y1, Xue W1, Huang Y2, Zhang J3. Author information Abstract PURPOSE: Renal cell carcinoma (RCC) is the most common malignancy of urogenital system, and patients with […]

Endocannabinoid-related compounds in gastrointestinal diseases.

J Cell Mol Med. 2017 Oct 9. doi: 10.1111/jcmm.13359. [Epub ahead of print] Pesce M1,2, D’Alessandro A1, Borrelli O2, Gigli S3, Seguella L3, Cuomo R1, Esposito G3, Sarnelli G1. Author information Abstract The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central […]

Potential of plant-sourced phenols for inflammatory bowel disease.

Curr Med Chem. 2017 Oct 9. doi: 10.2174/0929867324666171009100900. [Epub ahead of print] Xiao HT1, Wen B1, Shen XC2, Bian ZX1. Author information Abstract Inflammatory bowel disease (IBD) is an uncontrolled chronic inflammatory intestinal disorder, which requires medications for long-term therapy. Facing the challenges of severe side effects and drug resistance of conventional medications, to develop […]

A review of methods for the chemical characterization of cannabis natural products.

J Sep Sci. 2017 Oct 7. doi: 10.1002/jssc.201701003. [Epub ahead of print] Leghissa A1, Hildenbrand ZL2, Schug KA1. Author information Abstract Cannabis has garnered a great deal of new attention in the past couple of years in the United States due to the increasing instances of its legalization for recreational use and indications for medicinal […]