Archive | December, 2017

Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

J Epilepsy Res. 2017 Dec 31;7(2):61-76. doi: 10.14581/jer.17012. eCollection 2017 Dec. Perucca E1,2. Author information Abstract The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ(9) – tetrahydrocannabinol (THC), utilized primarily for recreational purposes, are generally unsuitable for this […]

The three betrayals of the medical cannabis growing activist: From multiple victimhood to reconstruction, redemption and activism.

Int J Drug Policy. 2017 Dec 26;53:65-72. doi: 10.1016/j.drugpo.2017.12.004. [Epub ahead of print] Klein A1, Potter GR2. Author information Abstract While cannabis has been widely used in the UK for over 50 years, it is only in recent decades that domestic cultivation has become established. Public concern, media reporting and policing policy has emphasised the […]

Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats.

BMC Urol. 2017 Dec 29;17(1):121. doi: 10.1186/s12894-017-0313-4. Kim SD1, Cho KJ2, Kim JC3. Author information Abstract BACKGROUND: This study investigated changes in the expression of cannabinoid (CB) receptors and the effects of CB1 and CB2 agonists on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO) in rats. METHODS: Male Sprague Dawley rats were randomly […]

Investigating the relationships between alcohol consumption, cannabis use and circulating cytokines: a preliminary analysis.

Alcohol Clin Exp Res. 2017 Dec 29. doi: 10.1111/acer.13592. [Epub ahead of print] Karoly HC1, Bidwell LC2, Mueller R1, Hutchison K1. Author information Abstract BACKGROUND: In recent years, human and animal studies have converged to support altered inflammatory signaling as one molecular mechanism underlying the pathophysiology of alcohol use disorders (AUDs). Alcohol binds to receptors […]

Marijuana Use and Renal Function Among US Adults.

Am J Med. 2017 Dec 29. pii: S0002-9343(17)31193-2. doi: 10.1016/j.amjmed.2017.10.051. [Epub ahead of print] Lu C1, Papatheodorou SI2, Danziger J3, Mittleman MA4. Author information Abstract BACKGROUND: In recent years, the number of states that have legalized medical marijuana or retail sales has increased, bringing potential changes of marijuana use pattern among the general population. However, […]

Routes of administration for cannabis use – basic prevalence and related health outcomes: A scoping review and synthesis.

Int J Drug Policy. 2017 Dec 22;52:87-96. doi: 10.1016/j.drugpo.2017.11.008. [Epub ahead of print] Russell C1, Rueda S2, Room R3, Tyndall M4, Fischer B5. Author information Abstract BACKGROUND: Cannabis use is common, and associated with adverse health outcomes. ‘Routes of administration’ (ROAs) for cannabis use have increasingly diversified, in part influenced by developments towards legalization. This […]

Peripheral Endocannabinoids Associated with Energy Expenditure in Native Americans of Southwestern Heritage.

J Clin Endocrinol Metab. 2017 Dec 28. doi: 10.1210/jc.2017-02257. [Epub ahead of print] Heinitz S1, Basolo A1, Piaggi P1, Piomelli D2, Jumpertz von Schwartzenberg R3,4,5, Krakoff J1. Author information Abstract CONTEXT: The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and the related acylethanolamide oleoylethanolamide (OEA) have been implicated in energy expenditure (EE)-regulation and metabolic diseases. Muscle […]

Conversation with Raphael Mechoulam

Explore this journal > Previous article in issue: Alcoholics Anonymous in Ireland: AA’s first European experience Next article in issue: Genetic and environmental influences on the relationship between peer alcohol use and own alcohol use in adolescents View  issue TOC Volume 102, Issue 6 June 2007 Pages 887–893 Conversation with Raphael Mechoulam First published: 22 […]

“You got to love rosin: Solventless dabs, pure, clean, natural medicine.” Exploring Twitter data on emerging trends in Rosin Tech marijuana concentrates.

Drug Alcohol Depend. 2017 Dec 27;183:248-252. doi: 10.1016/j.drugalcdep.2017.10.039. [Epub ahead of print] Lamy FR1, Daniulaityte R2, Zatreh M3, Nahhas RW4, Sheth A5, Martins SS6, Boyer EW7, Carlson RG2. Author information Abstract BACKGROUND: “Rosin tech” is an emerging solventless method consisting in applying moderate heat and constant pressure on marijuana flowers to prepare marijuana concentrates referred […]

PTL401, a New Formulation Based on Pro-nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers.

J Pharm Sci. 2017 Dec 26. pii: S0022-3549(17)30890-0. doi: 10.1016/j.xphs.2017.12.020. [Epub ahead of print] Atsmon J1, Cherniakov I2, Izgelov D2, Hoffman A2, Domb AJ2, Deutsch L3, Deutsch F3, Heffetz D4, Sacks H4. Author information Abstract There is growing clinical interest in developing and commercializing pharmaceutical-grade cannabinoid products, containing primarily tetrahydrocannabinol (THC) and cannabidiol (CBD). The […]