Archive | March, 2018

Reduced levels of the endocannabinoid arachidonylethanolamide (AEA) in hair in patients with borderline personality disorder – a pilot study.

Stress. 2018 Mar 16:1-4. doi: 10.1080/10253890.2018.1451837. [Epub ahead of print] Wingenfeld K1, Dettenborn L2, Kirschbaum C3, Gao W3, Otte C1, Roepke S1. Author information Abstract Endocannabinoids are involved in depressive and anxious symptoms and might play a role in stress-associated psychiatric disorders. While alterations in the endogenous cannabinoid system have been repeatedly found in patients […]

Cannabinoid Receptors, Mental Pain and Suicidal Behavior: a Systematic Review.

Curr Psychiatry Rep. 2018 Mar 15;20(3):19. doi: 10.1007/s11920-018-0880-4. Colino L1, Herranz-Herrer J1, Gil-Benito E1, Ponte-Lopez T1, Del Sol-Calderon P1, Rodrigo-Yanguas M1, Gil-Ligero M2, Sánchez-López AJ2,3,4, de Leon J5,6,7, Blasco-Fontecilla H8,9,10. Author information Abstract PURPOSE OF REVIEW: The current serotonin-based biological model of suicidal behavior (SB) may be too simplistic. There is emerging evidence that other […]

An overview of health and safety in the Colorado cannabis industry.

Am J Ind Med. 2018 Mar 14. doi: 10.1002/ajim.22834. [Epub ahead of print] Walters KM1, Fisher GG1, Tenney L2,3. Author information Abstract BACKGROUND: Understanding worker health and safety in the rapidly growing legal U.S. cannabis industry is important. Although little published research exists, workers may be exposed to biological, chemical, and physical hazards. This study […]

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.

Neurology. 2018 Mar 14. pii: 10.1212/WNL.0000000000005254. doi: 10.1212/WNL.0000000000005254. [Epub ahead of print] Devinsky O1, Patel AD2, Thiele EA2, Wong MH2, Appleton R2, Harden CL2, Greenwood S2, Morrison G2, Sommerville K2; GWPCARE1 Part A Study Group. Collaborators (8) Author information Abstract OBJECTIVE: To evaluate the safety and preliminary pharmacokinetics of a pharmaceutical formulation of purified cannabidiol […]

Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows.

Reprod Domest Anim. 2018 Mar 14. doi: 10.1111/rda.13169. [Epub ahead of print] Bonsale R1, Seyed Sharifi R1, Dirandeh E2, Hedayat N1, Mojtahedin A1, Ghorbanalinia M2, Abolghasemi A3. Author information Abstract The objective of this study was to consider endocannabinoid system as inflammatory markers in bovine endometrium to better understand the role of this system in […]

Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.

Seizure. 2018 Mar 12;57:22-26. doi: 10.1016/j.seizure.2018.03.009. [Epub ahead of print] Tchekalarova J1, da Conceição Machado K2, Gomes Júnior AL2, de Carvalho Melo Cavalcante AA3, Momchilova A4, Tzoneva R4. Author information Abstract PURPOSE: Activation of CB1 receptors, produces anticonvulsant effect accompanied by memory disturbance both in animal seizure tests and in patients with epilepsy. Few reports […]

Clinical response to Nabiximols correlates with the down-regulation of immune pathways in Multiple Sclerosis.

Eur J Neurol. 2018 Mar 12. doi: 10.1111/ene.13623. [Epub ahead of print] Sorosina M1, Clarelli F1, Ferrè L1,2, Osiceanu AM1, Unal NT3, Mascia E1, Martinelli V2, Comi G2, Benigni F3, Esposito F1,2, Martinelli Boneschi F1,4,5. Author information Abstract BACKGROUND: Nabiximols (Sativex® ) is a cannabinoid-based compound used for the treatment of moderate to severe spasticity […]

“The difference is in the tomato at the end”: Understanding the motivations and practices of cannabis growers operating within Belgian Cannabis Social Clubs.

Int J Drug Policy. 2018 Mar 11;56:21-29. doi: 10.1016/j.drugpo.2018.02.016. [Epub ahead of print] Pardal M1. Author information Abstract BACKGROUND: In Belgium, Cannabis Social Clubs (CSCs) collectively organize the cultivation and distribution of cannabisfor the personal use of their members. In this paper we seek to improve understanding of the motivations and practices of cannabis growers […]

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis.

Inflamm Bowel Dis. 2018 Mar 10. doi: 10.1093/ibd/izy002. [Epub ahead of print] Irving PM1, Iqbal T2, Nwokolo C3, Subramanian S4, Bloom S5, Prasad N6, Hart A7, Murray C8, Lindsay JO9, Taylor A10, Barron R10, Wright S10. Author information Abstract BACKGROUND: Cannabidiol (CBD) exhibits anti-inflammatory properties that could improve disease activity in inflammatory bowel disease. This […]

Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia.

Epilepsy Behav. 2018 Mar 8. pii: S1525-5050(17)30942-3. doi: 10.1016/j.yebeh.2018.02.009. [Epub ahead of print] Neubauer D1, Perković Benedik M1, Osredkar D2. Author information Abstract PURPOSE: Refractory epilepsies in children present a major burden for patients and their families. Cannabidiol (CBD) has been suggested as a potential treatment for refractory epilepsies. The aim of this study was […]