Tag Archives: blood pressure

Cannabinoids in the Cardiovascular System.

Adv Pharmacol. 2017;80:329-366. doi: 10.1016/bs.apha.2017.05.002. Epub 2017 Jul 3. Ho WSV1, Kelly MEM2. Author information Abstract Cannabinoids are known to modulate cardiovascular functions including heart rate, vascular tone, and blood pressure in humans and animal models. Essential components of the endocannabinoid system, namely, the production, degradation, and signaling pathways of endocannabinoids have been described not […]

A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.

JCI Insight. 2017 Jun 15;2(12). pii: 93760. doi: 10.1172/jci.insight.93760. [Epub ahead of print] Jadoon KA1, Tan GD2, O’Sullivan SE1. Author information Abstract BACKGROUND: Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid used in multiple sclerosis and intractable epilepsies. Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced blood pressure (BP) response to stress. The aim […]

A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol.

Front Pharmacol. 2017 Feb 24;8:81. doi: 10.3389/fphar.2017.00081. eCollection 2017. Sultan SR1, Millar SA1, England TJ1, O’Sullivan SE1. Author information Abstract Despite cannabidiol (CBD) having numerous cardiovascular effects in vitro, its haemodynamic effects in vivo are unclear. Nonetheless, the clinical use of CBD (Epidiolex) is becoming more widespread. The aim of this systematic review was to establish whether CBD is associated with changes in haemodynamics in […]

Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture.

 2015 Nov 11;10(11):e0142728. doi: 10.1371/journal.pone.0142728. eCollection 2015. Martins CJ1, Genelhu V1,2, Pimentel MM3, Celoria BM1, Mangia RF1, Aveta T4, Silvestri C4, Di Marzo V4, Francischetti EA1,2. Author information Abstract The dysregulation of the endocannabinoid system is associated with cardiometabolic complications of obesity. Allelic variants in coding genes for this system components may contribute to differences in the susceptibility to obesity and related health […]

Endocannabinoids and the Cardiovascular System in Health and Disease.

2015;231:393-422. O’Sullivan SE1. Author information Abstract The endocannabinoid system is widely distributed throughout the cardiovascular system. Endocannabinoids play a minimal role in the regulation of cardiovascular function in normal conditions, but are altered in most cardiovascular disorders. In shock, endocannabinoids released within blood mediate the associated hypotension through CB1 activation. In hypertension, there is evidence for […]

A pivotal role for enhanced brainstem orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats.

 2015 Jun 18. pii: S0006-8993(15)00482-5. doi: 10.1016/j.brainres.2015.06.011. [Epub ahead of print] Ibrahim BM1, Abdel-Rahman AA2. Author information Abstract Orexin receptor 1 (OX1R) signaling is implicated in cannabinoid receptor 1 (CB1R) modulation of feeding. Further, our studies established the dependence of the central CB1R-mediated pressor response on neuronal nitric oxide synthase (nNOS) and extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation in […]

ALTERATIONS IN THE MEDULLARY ENDOCANNABINOID SYSTEM CONTRIBUTE TO AGE-RELATED IMPAIRMENT OF BAROREFLEX SENSITIVITY.

2015 Jan 29. [Epub ahead of print] Schaich CL1, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Author information Abstract As they age, Sprague-Dawley (SD) rats develop elevated systolic blood pressure associated with impaired baroreflex sensitivity (BRS) for control of heart rate. We previously demonstrated in young hypertensive (mRen2)27 rats that impaired BRS is restored by CB1 cannabinoid receptor […]

Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension.

2015 Jan 13. pii: S0303-7207(15)00016-7. doi: 10.1016/j.mce.2015.01.012. [Epub ahead of print] Szekeres M1, Nádasy GL2, Turu G1, Soltész-Katona E1, Benyó Z2, Offermanns S3, Ruisanchez É2, Szabó E4, Takáts Z4, Bátkai S5, Tóth ZE6, Hunyady L7. Author information Abstract Activation of G protein-coupled receptors (GPCRs) can induce vasoconstriction via calcium signal-mediated and Rho-dependent pathways. Earlier reports have shown that diacylglycerol produced during calcium signal generation can be […]

Neuronal Nitric Oxide Synthase Dependent Elevation in Adiponectin in the Rostral Ventrolateral Medulla Underlies GPR18-mediated Hypotension in Conscious Rats.

 2014 Aug 6. pii: jpet.114.216036. [Epub ahead of print] Neuronal Nitric Oxide Synthase Dependent Elevation in Adiponectin in the Rostral Ventrolateral Medulla Underlies GPR18-mediated Hypotension in Conscious Rats. Penumarti A1, Abdel-Rahman AA2. Author information Abstract Direct activation (abnormal cannabidiol; Abn CBD) of the endocannabinoid receptor GPR18 in the rostral ventrolateral medulla (RVLM) of conscious rats elevates local […]

The Novel Endocannabinoid Receptor GPR18 is Expressed in the Rostral Ventrolateral Medulla and Exerts Tonic Restraining Influence on Blood Pressure.

 2014 Jan 15. [Epub ahead of print] The Novel Endocannabinoid Receptor GPR18 is Expressed in the Rostral Ventrolateral Medulla and Exerts Tonic Restraining Influence on Blood Pressure. Penumarti A, Abdel-Rahman AA. Author information Abstract Systemic administration of the GPR18 agonist abnormal cannabidiol (Abn CBD) lowers blood pressure (BP). Whether GPR18 is expressed in the CNS and […]