Tag Archives: Cannabidiol

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.

Neurology. 2018 Mar 14. pii: 10.1212/WNL.0000000000005254. doi: 10.1212/WNL.0000000000005254. [Epub ahead of print] Devinsky O1, Patel AD2, Thiele EA2, Wong MH2, Appleton R2, Harden CL2, Greenwood S2, Morrison G2, Sommerville K2; GWPCARE1 Part A Study Group. Collaborators (8) Author information Abstract OBJECTIVE: To evaluate the safety and preliminary pharmacokinetics of a pharmaceutical formulation of purified cannabidiol […]

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis.

Inflamm Bowel Dis. 2018 Mar 10. doi: 10.1093/ibd/izy002. [Epub ahead of print] Irving PM1, Iqbal T2, Nwokolo C3, Subramanian S4, Bloom S5, Prasad N6, Hart A7, Murray C8, Lindsay JO9, Taylor A10, Barron R10, Wright S10. Author information Abstract BACKGROUND: Cannabidiol (CBD) exhibits anti-inflammatory properties that could improve disease activity in inflammatory bowel disease. This […]

Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia.

Epilepsy Behav. 2018 Mar 8. pii: S1525-5050(17)30942-3. doi: 10.1016/j.yebeh.2018.02.009. [Epub ahead of print] Neubauer D1, Perković Benedik M1, Osredkar D2. Author information Abstract PURPOSE: Refractory epilepsies in children present a major burden for patients and their families. Cannabidiol (CBD) has been suggested as a potential treatment for refractory epilepsies. The aim of this study was […]

Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence.

J Neurol Neurosurg Psychiatry. 2018 Mar 6. pii: jnnp-2017-317168. doi: 10.1136/jnnp-2017-317168. [Epub ahead of print] Stockings E1, Zagic D1, Campbell G1, Weier M1, Hall WD2,3, Nielsen S1, Herkes GK4, Farrell M1, Degenhardt L1. Author information Abstract Review evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Systematic search of Medline, Embase and PsycINFO was conducted […]

The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling.

Neuropharmacology. 2018 Mar 3. pii: S0028-3908(18)30102-3. doi: 10.1016/j.neuropharm.2018.03.001. [Epub ahead of print] Fogaça MV1, de Campos AC2, Coelho LD2, Duman RS3, Guimarães FS2. Author information Abstract Repeated injections of cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, attenuate the anxiogenic effects induced by Chronic Unpredictable Stress (CUS). The specific mechanisms remain […]

Clinical Challenges in the Growing Medical Marijuana Field.

R I Med J (2013). 2018 Mar 1;101(2):12-13. Barker J1. Author information Abstract Unique clinical challenges arise with the growing number of patients who possess medical marijuana cards. Medical marijuana patients with mental disorders can have worsening symptoms with marijuana use. Often there is sparse continuity of care between the patient and the medical marijuana […]

The current state and future perspectives of cannabinoids in cancer biology.

Cancer Med. 2018 Feb 23. doi: 10.1002/cam4.1312. [Epub ahead of print] Śledziński P1, Zeyland J1, Słomski R1,2, Nowak A1. Author information Abstract To date, cannabinoids have been allowed in the palliative medicine due to their analgesic and antiemetic effects, but increasing number of preclinical studies indicates their anticancer properties. Cannabinoids exhibit their action by a […]

Analytical and Pharmacological Challenges in Cannabis Research

Planta Med 2018; 84(04): 213 DOI: 10.1055/s-0044-101051 Editorial Georg Thieme Verlag KG Stuttgart · New York Jürg Gertsch Further Information Abstract Full Text Buy Article Permissions and Reprints The millennial history of the use of cannabis as crop, medicinal and recreational plant reads like a novel in which the most recent chapter is dedicated to the […]

Learning and Memory is Modulated by Cannabidiol When Administered During Trace Fear-Conditioning.

Neurobiol Learn Mem. 2018 Feb 9. pii: S1074-7427(18)30022-4. doi: 10.1016/j.nlm.2018.02.009. [Epub ahead of print] Uhernik AL1, Montoya ZT1, Balkissoon CD1, Smith JP2. Author information Abstract Cannabidiol (CBD) is thought to have therapeutic potential for treating psychiatric conditions that affect cognitive aspects of learning and memory, including anxiety and post-traumatic stress disorder (PTSD). Studies have shown […]

Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center.

Epilepsy Behav. 2018 Feb 8. pii: S1525-5050(18)30009-X. doi: 10.1016/j.yebeh.2018.01.026. [Epub ahead of print] Porcari GS1, Fu C2, Doll ED2, Carter EG2, Carson RP3. Author information Abstract Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately 1 in 3 patients continues to have seizures. Cannabidiol (CBD), one […]