Tag Archives: Cannabidiol

Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial.

Am J Psychiatry. 2017 Dec 15:appiajp201717030325. doi: 10.1176/appi.ajp.2017.17030325. [Epub ahead of print] McGuire P1, Robson P1, Cubala WJ1, Vasile D1, Morrison PD1, Barron R1, Taylor A1, Wright S1. Author information Abstract OBJECTIVE: Research in both animals and humans indicates that cannabidiol (CBD) has antipsychotic properties. The authors assessed the safety and effectiveness of CBD in […]

From “Azalla” to Anandamide: Distilling the Therapeutic Potential of Cannabinoids

Rajiv RadhakrishnanCorrespondence information about the author Rajiv RadhakrishnanEmail the author Rajiv Radhakrishnan , David A. Ross Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut PlumX Metrics DOI: http://dx.doi.org/10.1016/j.biopsych.2017.11.017  Abstract > Full Text > Images >References Article Outline Acknowledgments and Disclosures References Root of caper which is on a grave, root of acacia…[and] azalla (cannabis); these seven drugs […]

Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells.

United European Gastroenterol J. 2017 Dec;5(8):1108-1115. doi: 10.1177/2050640617698622. Epub 2017 Mar 13. Gigli S1, Seguella L1, Pesce M2, Bruzzese E3, D’Alessandro A2, Cuomo R2, Steardo L1, Sarnelli G2, Esposito G1. Author information Abstract BACKGROUND: Clostridium difficile toxin A is responsible for colonic damage observed in infected patients. Drugs able to restore Clostridium difficile toxin A-induced […]

Cannabidiol Does Not Convert to Δ9-Tetrahydrocannabinol in an In Vivo Animal Model.

Cannabis Cannabinoid Res. 2017 Dec 1;2(1):282-287. doi: 10.1089/can.2017.0032. eCollection 2017. Wray L1, Stott C1, Jones N1, Wright S1. Author information Abstract Introduction: Cannabidiol (CBD) can convert to Δ9-tetrahydrocannabinol (THC) in vitro with prolonged exposure to simulated gastric fluid; however, in vitro conditions may not be representative of the in vivo gut environment. Using the minipig, […]

Development of a simple and sensitive liquid chromatography triple quadrupole mass spectrometry (LC-MS/MS) method for the determination of cannabidiol (CBD), Δ9-tetrahydrocannabinol (THC) and its metabolites in rat whole blood after oral administration of a single high dose of CBD.

J Pharm Biomed Anal. 2017 Nov 28;150:25-32. doi: 10.1016/j.jpba.2017.11.054. [Epub ahead of print] Palazzoli F1, Citti C2, Licata M3, Vilella A4, Manca L4, Zoli M4, Vandelli MA5, Forni F5, Cannazza G6. Author information Abstract The investigation of the possible conversion of cannabidiol (CBD) into Δ9-tetrahydrocannabinol (THC) in vivo after oral administration of CBD is reported […]

Simple and fast gas-chromatography mass spectrometry assay to assess delta 9-tetrahydrocannabinol and cannabidiol in dogs treated with medical cannabis for canine epilepsy.

Curr Pharm Biotechnol. 2017 Nov 21. doi: 10.2174/1389201018666171122115815. [Epub ahead of print] Rotolo MC1, Graziano S1, Pellegrini M1, Corlazzoli D2, Antinori L2, Porcarelli L2, Pichini S3. Author information Abstract BACKGROUND: To date, an increasing number of pet owners, especially in the USA, are using cannabis-derived products containing generally delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to […]

Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA).

J Pharm Biomed Anal. 2017 Nov 20;149:532-540. doi: 10.1016/j.jpba.2017.11.044. [Epub ahead of print] Citti C1, Pacchetti B2, Vandelli MA3, Forni F3, Cannazza G4. Author information Abstract Hemp seed oil from Cannabis sativa L. is a very rich natural source of important nutrients, not only polyunsaturated fatty acids and proteins, but also terpenes and cannabinoids, which […]

Single-Dose Pharmacokinetics of Oral Cannabidiol Following Administration of PTL101: A New Formulation Based on Gelatin Matrix Pellets Technology.

Clin Pharmacol Drug Dev. 2017 Nov 10. doi: 10.1002/cpdd.408. [Epub ahead of print] Atsmon J1, Heffetz D2, Deutsch L3, Deutsch F3, Sacks H2. Author information Abstract Cannabidiol (CBD) is the main nonpsychoactive component of the cannabis plant. It has been associated with antiseizure, antioxidant, neuroprotective, anxiolytic, anti-inflammatory, antidepressant, and antipsychotic effects. PTL101 is an oral […]

Cannabidiol as a treatment for epilepsy

Journal of Neurology – pp 1–3| Cite as Authors > Authors and affiliations >William O. Pickrell >Neil P. Robertson Email author Open Access Journal club First Online: 09 November 2017 Download fulltext PDF Despite an increasing number of anti-epileptic drugs (AEDs), the proportion of drug-resistant cases of epilepsy has remained fairly static at around 30% and the search for new and improved AEDs continues. […]

Microwave-Assisted Extraction of Cannabinoids in Hemp Nut Using Response Surface Methodology: Optimization and Comparative Study.

Molecules. 2017 Nov 3;22(11). pii: E1894. doi: 10.3390/molecules22111894. Chang CW1, Yen CC2, Wu MT3, Hsu MC4,5, Wu YT6,7. Author information Abstract Hemp nut is commonly incorporated into several food preparations; however, most countries set regulations for hemp products according to their cannabinoid content. In this study, we have developed an efficient microwave-assisted extraction (MAE) method […]