Tag Archives: epilepsy

The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity.

Sci Rep. 2017 Sep 11;7(1):11152. doi: 10.1038/s41598-017-11606-1. Colangeli R1, Pierucci M2, Benigno A3, Campiani G4, Butini S4, Di Giovanni G5,6. Author information Abstract Synthetic cannabinoids and phytocannabinoids have been shown to suppress seizures both in humans and experimental models of epilepsy. However, they generally have a detrimental effect on memory and memory-related processes. Here we […]

Effects of arachidonyl-2′-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.

PLoS One. 2017 Aug 31;12(8):e0183873. doi: 10.1371/journal.pone.0183873. eCollection 2017. Luszczki JJ1,2, Patrzylas P2,3, Zagaja M2, Andres-Mach M2, Zaluska K1, Kondrat-Wrobel MW1, Szpringer M4, Chmielewski J5, Florek-Luszczki M6. Author information Abstract Accumulating evidence indicates that cannabinoid CB1 receptor ligands play a pivotal role in seizures, not only in preclinical studies on animals, but also in clinical […]

Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels.

Epilepsy Behav. 2017 Aug 15;75:29-35. doi: 10.1016/j.yebeh.2017.07.014. [Epub ahead of print] Vilela LR1, Lima IV2, Kunsch ÉB2, Pinto HPP3, de Miranda AS4, Vieira ÉLM1, de Oliveira ACP2, Moraes MFD3, Teixeira AL5, Moreira FA6. Author information Abstract Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits experimental seizures in animal models and alleviates certain types […]

Modulation of GABAA receptors in the treatment of epilepsy.

Curr Pharm Des. 2017 Aug 9. doi: 10.2174/1381612823666170809100230. [Epub ahead of print] Palma E1, Ruffolo G1, Cifelli P2, Roseti C3, van Vliet EA4, Aronica E4. Author information Abstract BACKGROUND: A variety of evidence suggested that an imbalance in excitatory and inhibitory neurotransmission could be one of the pathophysiological mechanisms underlying the occurrence and progression of […]

Antiepileptic drugs in clinical development: differentiate or die?

Curr Pharm Des. 2017 Aug 9. doi: 10.2174/1381612823666170809100524. [Epub ahead of print] Zaccara G1, Schmidt D2. Author information Abstract BACKGROUND: Animal models when carefully selected, designed and conducted, are important parts of any translational drug development strategy. However, research of new compounds for patients with drug-resistant epilepsies is still based on animal experiments, mostly in […]

Interactions between cannabidiol and commonly used antiepileptic drugs.

Epilepsia. 2017 Aug 6. doi: 10.1111/epi.13852. [Epub ahead of print] Gaston TE1, Bebin EM1,2, Cutter GR3, Liu Y3, Szaflarski JP1; UAB CBD Program. Author information Abstract OBJECTIVE: To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Serum levels were […]

Parent use of cannabis for intractable pediatric epilepsy: Everyday empiricism and the boundaries of scientific medicine.

Soc Sci Med. 2017 Aug 5;190:190-198. doi: 10.1016/j.socscimed.2017.08.003. [Epub ahead of print] Sobo EJ1. Author information Abstract Cannabis is an increasingly sought-after remedy for US children with intractable (biomedically uncontrollable) epilepsy. However, like other complementary-alternative medicine (CAM) modalities, and particularly as a federally illegal, stigmatized substance, it is unsanctioned by mainstream medicine. Parents are largely […]

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid.

Int J Mol Sci. 2017 Jul 31;18(8). pii: E1669. doi: 10.3390/ijms18081669. Kozela E1,2, Juknat A3,4, Vogel Z5,6. Author information Abstract The astrocytes have gained in recent decades an enormous interest as a potential target for neurotherapies, due to their essential and pleiotropic roles in brain physiology and pathology. Their precise regulation is still far from […]

Fewer Seizures With Cannabidiol in Catastrophic Epilepsy

Clinical Trials Update July 25, 2017 Anita Slomski, MA JAMA. 2017;318(4):323. doi:10.1001/jama.2017.8846 Cannabidiol reduced the frequency of convulsive seizures compared with placebo in Dravet syndrome, a childhood epilepsy disorder with a high mortality rate and no approved treatment in the United States, reported a clinical trial in the New England Journal of Medicine The study randomly assigned 120 children […]

[Cannabidiol: its use in refractory epilepsies].

Rev Neurol. 2017 Aug 16;65(4):157-160. [Article in Spanish; Abstract available in Spanish from the publisher] Pesantez-Rios G1, Armijos-Acurio L2, Jimbo-Sotomayor R2,3, Pascual-Pascual SI4, Pesantez-Cuesta G1. Author information Abstract in English, Spanish INTRODUCTION: Some epileptic syndromes are characterised by seizures that are difficult to control and are associated to delayed neuropsychomotor development, which results in a […]