Tag Archives: epilepsy

Cannabidiol as a treatment for epilepsy

Journal of Neurology – pp 1–3| Cite as Authors > Authors and affiliations >William O. Pickrell >Neil P. Robertson Email author Open Access Journal club First Online: 09 November 2017 Download fulltext PDF Despite an increasing number of anti-epileptic drugs (AEDs), the proportion of drug-resistant cases of epilepsy has remained fairly static at around 30% and the search for new and improved AEDs continues. […]

Cannabinoid receptor 1/2 double-knockout mice develop epilepsy.

Epilepsia. 2017 Nov 3. doi: 10.1111/epi.13930. [Epub ahead of print] Rowley S1, Sun X2, Lima IV1,3, Tavenier A2, de Oliveira ACP3, Dey SK2, Danzer SC1,4. Author information Abstract The endocannabinoid system has gained attention as an important modulator of activity in the central nervous system. Initial studies focused on cannabinoid receptor 1 (CB1), which is […]

The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy.

Neurocase. 2017 Oct 24:1-5. doi: 10.1080/13554794.2017.1391294. [Epub ahead of print] Warren PP1, Bebin EM1, Nabors LB1, Szaflarski JP1. Author information Abstract Epilepsy, commonly encountered by patients with brain tumors, is often refractory to standard therapies. Our aim was to examine the safety and efficacy of pharmaceutical grade cannabidiol (CBD; Epidiolex, GW Pharmaceuticals) in those patients […]

Medical Cannabinoids in Children and Adolescents: A Systematic Review.

Pediatrics. 2017 Oct 23. pii: e20171818. doi: 10.1542/peds.2017-1818. [Epub ahead of print] Wong SS1, Wilens TE2. Author information Abstract CONTEXT: Legalization of medical marijuana in many states has led to a widening gap between the accessibility and the evidence for cannabinoids as a medical treatment. OBJECTIVE: To systematically review published reports to identify the evidence […]

Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.

Proc Natl Acad Sci U S A. 2017 Oct 2. pii: 201711351. doi: 10.1073/pnas.1711351114. [Epub ahead of print] Kaplan JS1, Stella N1,2, Catterall WA3, Westenbroek RE1. Author information Abstract Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its efficacy from preclinical and clinical studies. Here we show that cannabidiol (CBD) effectively […]

A Resurging Boom in New Drugs for Epilepsy and Brain Disorders.

Expert Rev Clin Pharmacol. 2017 Sep 28. doi: 10.1080/17512433.2018.1386553. [Epub ahead of print] Younus I1, Reddy DS2. Author information Abstract INTRODUCTION: Epilepsy is one of the most common neurological diseases affecting approximately 50 million people worldwide. Despite many advances in epilepsy research, nearly a third of patients with epilepsy have refractory or pharmacoresistant epilepsy. Despite […]

Cannabidiol reduced frequency of convulsive seizures in drug resistant Dravet syndrome

Author affiliations http://dx.doi.org/10.1136/archdischild-2017-31370 Published in Archives of Disease in Childhood — Education & Practice Edition, September 2017 DOI 10.1136/archdischild-2017-313700 Pubmed ID 28939549 Authors Yasmin Moore, Robert Robinson Study design Design: Multinational double-blinded placebo-controlled trial. Patients randomised in 1:1 ratio to receive cannabidiol or placebo, in addition to stable antiepileptic treatment regime. Study question Setting: Twenty-three […]

Efficacy and safety of cannabis for treating children with refractory epilepsy.

Nurs Child Young People. 2017 Sep 11;29(7):32-37. doi: 10.7748/ncyp.2017.e907. Neale M1. Author information Abstract The aim of this literature review was to examine the evidence base for the safety and efficacy of cannabis in treating children with refractory epilepsy. Clinical and medical databases were searched and four articles were included in the final analysis, which […]

The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity.

Sci Rep. 2017 Sep 11;7(1):11152. doi: 10.1038/s41598-017-11606-1. Colangeli R1, Pierucci M2, Benigno A3, Campiani G4, Butini S4, Di Giovanni G5,6. Author information Abstract Synthetic cannabinoids and phytocannabinoids have been shown to suppress seizures both in humans and experimental models of epilepsy. However, they generally have a detrimental effect on memory and memory-related processes. Here we […]

Effects of arachidonyl-2′-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.

PLoS One. 2017 Aug 31;12(8):e0183873. doi: 10.1371/journal.pone.0183873. eCollection 2017. Luszczki JJ1,2, Patrzylas P2,3, Zagaja M2, Andres-Mach M2, Zaluska K1, Kondrat-Wrobel MW1, Szpringer M4, Chmielewski J5, Florek-Luszczki M6. Author information Abstract Accumulating evidence indicates that cannabinoid CB1 receptor ligands play a pivotal role in seizures, not only in preclinical studies on animals, but also in clinical […]