Tag Archives: epilepsy

The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report.

Eur J Intern Med. 2018 Jan 8. pii: S0953-6205(18)30003-7. doi: 10.1016/j.ejim.2018.01.003. [Epub ahead of print] Abrams DI1. Author information Abstract The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a […]

Do Cannabinoids Confer Neuroprotection Against Epilepsy? An Overview.

Open Neurol J. 2017 Dec 18;11:61-73. doi: 10.2174/1874205X01711010061. eCollection 2017. Capasso A1. Author information Abstract OBJECTIVE: Cannabinoid-based medications provide not only relief for specific symptoms, but also arrest or delay of disease progression in patients with pain, multiple sclerosis, and other conditions. Although they also seem to hold potential as anticonvulsant agents, evidence of their […]

Cannabinoids for epilepsy: What do we know and where do we go?

Epilepsia. 2017 Dec 6. doi: 10.1111/epi.13973. [Epub ahead of print] Brodie MJ1, Ben-Menachem E2. Author information Abstract Over the past decade there has been an increasing interest in using cannabinoids to treat a range of epilepsy syndromes following reports of some remarkable responses in individual patients. The situation is complicated by the fact that these […]

Cannabidiol as a treatment for epilepsy

Journal of Neurology – pp 1–3| Cite as Authors > Authors and affiliations >William O. Pickrell >Neil P. Robertson Email author Open Access Journal club First Online: 09 November 2017 Download fulltext PDF Despite an increasing number of anti-epileptic drugs (AEDs), the proportion of drug-resistant cases of epilepsy has remained fairly static at around 30% and the search for new and improved AEDs continues. […]

Cannabinoid receptor 1/2 double-knockout mice develop epilepsy.

Epilepsia. 2017 Nov 3. doi: 10.1111/epi.13930. [Epub ahead of print] Rowley S1, Sun X2, Lima IV1,3, Tavenier A2, de Oliveira ACP3, Dey SK2, Danzer SC1,4. Author information Abstract The endocannabinoid system has gained attention as an important modulator of activity in the central nervous system. Initial studies focused on cannabinoid receptor 1 (CB1), which is […]

The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy.

Neurocase. 2017 Oct 24:1-5. doi: 10.1080/13554794.2017.1391294. [Epub ahead of print] Warren PP1, Bebin EM1, Nabors LB1, Szaflarski JP1. Author information Abstract Epilepsy, commonly encountered by patients with brain tumors, is often refractory to standard therapies. Our aim was to examine the safety and efficacy of pharmaceutical grade cannabidiol (CBD; Epidiolex, GW Pharmaceuticals) in those patients […]

Medical Cannabinoids in Children and Adolescents: A Systematic Review.

Pediatrics. 2017 Oct 23. pii: e20171818. doi: 10.1542/peds.2017-1818. [Epub ahead of print] Wong SS1, Wilens TE2. Author information Abstract CONTEXT: Legalization of medical marijuana in many states has led to a widening gap between the accessibility and the evidence for cannabinoids as a medical treatment. OBJECTIVE: To systematically review published reports to identify the evidence […]

Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.

Proc Natl Acad Sci U S A. 2017 Oct 2. pii: 201711351. doi: 10.1073/pnas.1711351114. [Epub ahead of print] Kaplan JS1, Stella N1,2, Catterall WA3, Westenbroek RE1. Author information Abstract Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its efficacy from preclinical and clinical studies. Here we show that cannabidiol (CBD) effectively […]

A Resurging Boom in New Drugs for Epilepsy and Brain Disorders.

Expert Rev Clin Pharmacol. 2017 Sep 28. doi: 10.1080/17512433.2018.1386553. [Epub ahead of print] Younus I1, Reddy DS2. Author information Abstract INTRODUCTION: Epilepsy is one of the most common neurological diseases affecting approximately 50 million people worldwide. Despite many advances in epilepsy research, nearly a third of patients with epilepsy have refractory or pharmacoresistant epilepsy. Despite […]

Cannabidiol reduced frequency of convulsive seizures in drug resistant Dravet syndrome

Author affiliations http://dx.doi.org/10.1136/archdischild-2017-31370 Published in Archives of Disease in Childhood — Education & Practice Edition, September 2017 DOI 10.1136/archdischild-2017-313700 Pubmed ID 28939549 Authors Yasmin Moore, Robert Robinson Study design Design: Multinational double-blinded placebo-controlled trial. Patients randomised in 1:1 ratio to receive cannabidiol or placebo, in addition to stable antiepileptic treatment regime. Study question Setting: Twenty-three […]