Tag Archives: epilepsy

Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia.

Epilepsy Behav. 2018 Mar 8. pii: S1525-5050(17)30942-3. doi: 10.1016/j.yebeh.2018.02.009. [Epub ahead of print] Neubauer D1, Perković Benedik M1, Osredkar D2. Author information Abstract PURPOSE: Refractory epilepsies in children present a major burden for patients and their families. Cannabidiol (CBD) has been suggested as a potential treatment for refractory epilepsies. The aim of this study was […]

Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence.

J Neurol Neurosurg Psychiatry. 2018 Mar 6. pii: jnnp-2017-317168. doi: 10.1136/jnnp-2017-317168. [Epub ahead of print] Stockings E1, Zagic D1, Campbell G1, Weier M1, Hall WD2,3, Nielsen S1, Herkes GK4, Farrell M1, Degenhardt L1. Author information Abstract Review evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Systematic search of Medline, Embase and PsycINFO was conducted […]

Analytical and Pharmacological Challenges in Cannabis Research

Planta Med 2018; 84(04): 213 DOI: 10.1055/s-0044-101051 Editorial Georg Thieme Verlag KG Stuttgart · New York Jürg Gertsch Further Information Abstract Full Text Buy Article Permissions and Reprints The millennial history of the use of cannabis as crop, medicinal and recreational plant reads like a novel in which the most recent chapter is dedicated to the […]

Cannabis for paediatric epilepsy: challenges and conundrums.

Med J Aust. 2018 Feb 19;208(3):132-136. Chen KA1, Farrar MA2, Cardamone M2, Lawson JA2. Author information Abstract Research is expanding for the use of cannabidiol as an anticonvulsant drug. The mechanism of cannabidiol in paediatric epilepsy is unclear but is thought to play a role in modulation of synaptic transmission. Evidence for its efficacy in […]

Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center.

Epilepsy Behav. 2018 Feb 8. pii: S1525-5050(18)30009-X. doi: 10.1016/j.yebeh.2018.01.026. [Epub ahead of print] Porcari GS1, Fu C2, Doll ED2, Carter EG2, Carson RP3. Author information Abstract Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately 1 in 3 patients continues to have seizures. Cannabidiol (CBD), one […]

Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin.

Front Mol Neurosci. 2018 Feb 6;11:32. doi: 10.3389/fnmol.2018.00032. eCollection 2018. Maggio N1,2,3, Shavit Stein E1, Segal M4. Author information Abstract Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol(CBD) […]

Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities.

Mol Neurobiol. 2018 Jan 25. doi: 10.1007/s12035-018-0898-y. [Epub ahead of print] Upadhya D1,2,3, Castro OW1,2,4, Upadhya R1,2, Shetty AK5,6. Author information Abstract The hippocampus is one of the most susceptible regions in the brain to be distraught with status epilepticus (SE) induced injury. SE can occur from numerous causes and is more frequent in children […]

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial.

Lancet. 2018 Jan 25. pii: S0140-6736(18)30136-3. doi: 10.1016/S0140-6736(18)30136-3. [Epub ahead of print] Thiele EA1, Marsh ED2, French JA3, Mazurkiewicz-Beldzinska M4, Benbadis SR5, Joshi C6, Lyons PD7, Taylor A8, Roberts C8, Sommerville K9; GWPCARE4 Study Group. Collaborators (34) Author information Abstract BACKGROUND: Patients with Lennox-Gastaut syndrome, a rare, severe form of epileptic encephalopathy, are frequently treatment […]

The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report.

Eur J Intern Med. 2018 Jan 8. pii: S0953-6205(18)30003-7. doi: 10.1016/j.ejim.2018.01.003. [Epub ahead of print] Abrams DI1. Author information Abstract The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a […]

Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

J Epilepsy Res. 2017 Dec 31;7(2):61-76. doi: 10.14581/jer.17012. eCollection 2017 Dec. Perucca E1,2. Author information Abstract The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ(9) – tetrahydrocannabinol (THC), utilized primarily for recreational purposes, are generally unsuitable for this […]