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Chemical Tools for Studying Lipid-Binding Class A G Protein-Coupled Receptors.

Pharmacol Rev. 2017 Jul;69(3):316-353. doi: 10.1124/pr.116.013243. Cooper A1, Singh S1, Hook S1, Tyndall JDA1, Vernall AJ2. Author information Abstract Cannabinoid, free fatty acid, lysophosphatidic acid, sphingosine 1-phosphate, prostanoid, leukotriene, bile acid, and platelet-activating factor receptor families are class A G protein-coupled receptors with endogenous lipid ligands. Pharmacological tools are crucial for studying these receptors and […]

Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

Neuropsychopharmacology. 2017 Jun 27. doi: 10.1038/npp.2017.130. [Epub ahead of print] Hillard CJ1. Author information Abstract The goal of this review is to summarize studies in which concentrations of circulating endocannabinoids in humans have been examined in relationship to physiological measurements and pathological status. The roles of endocannabinoids in the regulation of energy intake and storage […]

Incretin Secretion in Humans is under the Influence of Cannabinoid Receptors.

Am J Physiol Endocrinol Metab. 2017 Jun 27:ajpendo.00080.2017. doi: 10.1152/ajpendo.00080.2017. [Epub ahead of print] Chia CW1, Carlson OD2, Liu DD2, González-Mariscal I2, Santa-Cruz Calvo S2, Egan JM2. Author information Abstract The mechanisms regulating incretin secretion are not fully known. Human obesity is associated with altered incretin secretion and elevated endocannabinoid levels. Since cannabinoid receptors (CBRs) […]

Commentary: Navigating the complexities of marijuana.

Prev Med. 2017 Jun 23. pii: S0091-7435(17)30230-X. doi: 10.1016/j.ypmed.2017.06.026. [Epub ahead of print] Weiss S1, Wargo EM2. Author information Abstract Science needs to drive our thinking as we navigate a new legislative environment in which many Americans have access to marijuana for therapeutic or recreational use. With the responsibility to fund, conduct, and make use […]

Levels of oxylipins, endocannabinoids and related lipids in plasma before and after low-level exposure to acrolein in healthy individuals and individuals with chemical intolerance.

Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:60-67. doi: 10.1016/j.plefa.2017.06.004. Epub 2017 Jun 15. Claeson AS1, Gouveia-Figueira S2, Häggström J3, Fowler CJ4, Nording ML2. Author information Abstract Oxylipins and endocannabinoids play important biological roles, including effects upon inflammation. It is not known whether the circulating levels of these lipids are affected by inhalation of the environmental […]

Perspectives of Cannabinoid type 2 receptor (CB2R) ligands in neurodegenerative disorders: Structure Affinity Relationship (SAfiR) and Structure Activity Relationship (SAR) Studies.

J Med Chem. 2017 Jun 13. doi: 10.1021/acs.jmedchem.7b00155. [Epub ahead of print] Spinelli F, Capparelli E, Abate C, Colabufo NA, Contino M. Abstract Up-regulation of CB2R on activated microglial cells, the first step in neurodegeneration, has been widely demonstrated, and this finding makes the receptor a promising target in the early diagnosis and treatment of […]

Attitudes Toward Medical Cannabis Legalization Among Serbian Medical Students.

Subst Use Misuse. 2017 Jun 12:1-7. doi: 10.1080/10826084.2017.1302959. [Epub ahead of print] Vujcic I1, Pavlovic A1, Dubljanin E2, Maksimovic J1, Nikolic A1, Sipetic-Grujicic S1. Author information Abstract BACKGROUND: Currently, medical cannabis polices are experiencing rapid changes, and an increasing number of nations around the world legalize medical cannabis for certain groups of patients, including those […]

Loose regulation of medical marijuana programs associated with higher rates of adult marijuana use but not cannabis use disorder.

Addiction. 2017 Jun 10. doi: 10.1111/add.13904. [Epub ahead of print] Williams AR1, Santaella-Tenorio J1, Mauro CM1, Levin FR1, Martins SS1. Author information Abstract BACKGROUND AND AIMS: Most U.S. states have passed medical marijuana laws (MMLs), with great variation in program regulation impacting enrollment rates. We aimed to compare changes in rates of marijuana use, heavy […]

A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity.

Hippocampus. 2017 Jun 8. doi: 10.1002/hipo.22747. [Epub ahead of print] Hurst K1, Badgley C1, Ellsworth T1, Bell S1,2, Friend L1,2, Prince B1, Welch J1, Cowan Z1, Williamson R1,2, Lyon C1, Anderson B1, Poole B1,2, Christensen M1,2, McNeil M1, Call J1, Edwards JG1,2. Author information Abstract GPR55, an orphan G-protein coupled receptor, is activated by lysophosphatidylinositol […]

Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK.

Chem Biol Interact. 2017 Jun 7. pii: S0009-2797(16)30434-3. doi: 10.1016/j.cbi.2017.06.005. [Epub ahead of print] Hwang YS1, Kim YJ2, Kim MO3, Kang M3, Oh SW3, Nho YH4, Park SH5, Lee J6. Author information Abstract Melanogenesis plays a critical role in the protection of skin against external stresses such as ultraviolet irradiation and oxidative stressors. This study […]