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[Argentina enacts first law on medical use of the cannabis plant. History and perspectives].

Medicina (B Aires). 2017;77(5):388-393. [Article in Spanish] De Vito EL1. Author information Abstract In the last few years, great expectations have risen in the society concerning the eventual therapeutic usefulness of compounds derived from the cannabis plant. It is well known that these compounds are being used in treating certain health conditions, either through medical […]

THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study.

Neurol Sci. 2017 Oct 19. doi: 10.1007/s10072-017-3148-6. [Epub ahead of print] Maniscalco GT1,2, Aponte R3, Bruzzese D4, Guarcello G5, Manzo V6, Napolitano M6, Moreggia O5, Chiariello F3, Florio C5,6. Author information Abstract Lower urinary tract dysfunctions (LUTDs) are commonly reported in multiple sclerosis (MS) patients and are mainly related to neurogenic overactive bladder (OAB). The […]

Inverse association of marijuana use with nonalcoholic fatty liver disease among adults in the United States.

PLoS One. 2017 Oct 19;12(10):e0186702. doi: 10.1371/journal.pone.0186702. eCollection 2017. Kim D1, Kim W2, Kwak MS3, Chung GE3, Yim JY3, Ahmed A1. Author information Abstract BACKGROUND & AIMS: The impact of marijuana on nonalcoholic fatty liver disease (NAFLD) is largely unknown. We studied the association between marijuana and NAFLD utilizing cross-sectional data from the National Health […]

Cannabis in fat: high hopes to treat obesity.

J Clin Invest. 2017 Oct 16. pii: 97042. doi: 10.1172/JCI97042. [Epub ahead of print] Hawkins MN1,2, Horvath TL2,3. Author information Abstract Cannabinoid receptor type-1 (CB1s) is known to have a substantial impact on the regulation of energy metabolism via central and peripheral mechanisms. In this issue of the JCI, Ruiz de Azua and colleagues provide […]

Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.

J Clin Invest. 2017 Oct 16. pii: 83626. doi: 10.1172/JCI83626. [Epub ahead of print] Ruiz de Azua I1, Mancini G1, Srivastava RK1, Rey AA1, Cardinal P2,3, Tedesco L4, Zingaretti CM5, Sassmann A6, Quarta C7,8, Schwitter C1, Conrad A1, Wettschureck N6, Vemuri VK9, Makriyannis A9, Hartwig J10, Mendez-Lago M10, Bindila L1, Monory K1, Giordano A5, Cinti […]

Activation of cannabinoid receptor 1 is involved in protection against mitochondrial dysfunction and cerebral ischaemic tolerance induced by isoflurane preconditioning.

Br J Anaesth. 2017 Oct 13. doi: 10.1093/bja/aex267. [Epub ahead of print] Cai M1,2, Yang Q1, Li G1, Sun S1, Chen Y1, Tian L1, Dong H1. Author information Abstract BACKGROUND: Isoflurane preconditioning (IPC) induces cerebral ischaemic tolerance, but the mechanism remains poorly understood. The aim of this study was to determine changes in mitochondrial function […]

Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy.

J Am Soc Nephrol. 2017 Oct 13. pii: ASN.2017040371. doi: 10.1681/ASN.2017040371. [Epub ahead of print] Hinden L1, Udi S1, Drori A1, Gammal A1, Nemirovski A1, Hadar R1, Baraghithy S1, Permyakova A1, Geron M2, Cohen M3,4, Tsytkin-Kirschenzweig S3,4, Riahi Y5, Leibowitz G5, Nahmias Y3,4, Priel A2, Tam J6. Author information Abstract Altered glucose reabsorption via the […]

Recreational Cannabis Legalization and Opioid-Related Deaths in Colorado, 2000-2015.

Am J Public Health. 2017 Nov;107(11):1827-1829. doi: 10.2105/AJPH.2017.304059. Livingston MD1, Barnett TE1, Delcher C1, Wagenaar AC1. Author information Abstract OBJECTIVES: To examine the association between Colorado’s legalization of recreational cannabis use and opioid-related deaths. METHODS: We used an interrupted time-series design (2000-2015) to compare changes in level and slope of monthly opioid-related deaths before and […]

Human bone marrow mesenchymal stem cells secrete endocannabinoids that stimulate in vitro hematopoietic stem cell migration effectively comparable to beta adrenergic stimulation.

Exp Hematol. 2017 Oct 10. pii: S0301-472X(17)30813-5. doi: 10.1016/j.exphem.2017.09.009. [Epub ahead of print] Köse S1, Aerts-Kaya F1, Köprü AZ2, Nemutlu E3, Kuşkonmaz B4, Karaosmanoğlu B1, Taşkıran ZE5, Altun B6, Uçkan Çetinkaya D7, Korkusuz P8. Author information Abstract Granulocyte Colony-Stimulating Factor (G-CSF) is a well-known hematopoietic stem cell (HSC) mobilizing agent used in both allogeneic and […]

Effects of cannabinoid receptor type 2 in respiratory syncytial virus infection in human subjects and mice.

Virulence. 2017 Oct 9:0. doi: 10.1080/21505594.2017.1389369. [Epub ahead of print] Tahamtan A1, Samieipoor Y1, Nayeri FS2, Rahbarimanesh AA3, Izadi A3, Rashidi-Nezhad A4, Tavakoli-Yaraki M5, Farahmand M1, Bont L6, Shokri F7, Mokhatri-Azad T1, Salimi V1. Author information Abstract An accumulating body of evidence suggests that the endocannabinoid system plays a significant role in pathophysiological processes and […]