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AM1241 alleviates MPTP-induced Parkinson’s disease and promotes the regeneration of DA neurons in PD mice.

Oncotarget. 2017 Jun 29;8(40):67837-67850. doi: 10.18632/oncotarget.18871. eCollection 2017 Sep 15. Shi J#1,2, Cai Q#1, Zhang J1, He X1, Liu Y1, Zhu R1,3, Jin L1. Author information Abstract The main pathological feature of Parkinson’s disease (PD) is the loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the role of cannabinoid receptor […]

Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus co-infected patients (ANRS CO13-HEPAVIH).

J Viral Hepat. 2017 Oct 6. doi: 10.1111/jvh.12797. [Epub ahead of print] Nordmann S1,2, Vilotitch A1,2, Roux P1,2, Esterle L3, Spire B1,2, Marcellin F1,2, Salmon-Ceron D4,5, Dabis F3, Chas J6, Rey D7, Wittkop L3, Sogni P5,8, Carrieri P1,2; ANRS CO13 HEPAVIH Study Group. Author information Abstract Liver steatosis is common in Human Immunodeficiency Virus (HIV) […]

Cannabis and Cannabinoids for Chronic Pain.

Curr Rheumatol Rep. 2017 Oct 5;19(11):67. doi: 10.1007/s11926-017-0693-1. Romero-Sandoval EA1, Kolano AL2, Alvarado-Vázquez PA3. Author information Abstract PURPOSE OF REVIEW: The purpose of this study was to provide the most up-to-date scientific evidence of the potential analgesic effects, or lack thereof, of the marijuana plant (cannabis) or cannabinoids, and of safety or tolerability of their […]

Photobiomodulation Therapy Improves Acute Inflammatory Response in Mice: the Role of Cannabinoid Receptors/ATP-Sensitive K+ Channel/p38-MAPK Signalling Pathway.

Mol Neurobiol. 2017 Oct 4. doi: 10.1007/s12035-017-0792-z. [Epub ahead of print] Neves LMS1,2, Gonçalves ECD1,3, Cavalli J1, Vieira G1, Laurindo LR1, Simões RR4, Coelho IS3,4, Santos ARS3,4, Marcolino AM2, Cola M1, Dutra RC5,6. Author information Abstract Although photobiomodulation therapy (PBM) has been applied clinically for the treatment of pain and inflammation, wound healing, sports and […]

Human serum albumin: A modulator of cannabinoid drugs.

IUBMB Life. 2017 Oct 4. doi: 10.1002/iub.1682. [Epub ahead of print] Leboffe L1, di Masi A1, Trezza V1, Polticelli F1, Ascenzi P1. Author information Abstract The endocannabinoid system is a unique neuromodulatory system that affects a wide range of biological processes and maintains the homeostasis in all mammal body systems. In recent years, several pharmacological […]

Comparing Black and White Drug Offenders: Implications for Racial Disparities in Criminal Justice and Reentry Policy and Programming.

J Drug Issues. 2017;47(1):132-142. doi: 10.1177/0022042616678614. Epub 2016 Dec 21. Rosenberg A1, Groves AK2, Blankenship KM3. Author information Abstract Despite knowledge of racial bias for drug-related criminal justice involvement and its collateral consequences, we know less about differences between Black and White drug offenders. We compare 243 Blacks and White non-violent drug offenders in New […]

Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model.

J Pharmacol Exp Ther. 2017 Oct 2. pii: jpet.117.243808. doi: 10.1124/jpet.117.243808. [Epub ahead of print] Wilkerson JL1, Donvito G2, Grim TW3, Abdullah RA2, Ogasawara D3, Cravatt BF3, Lichtman AH2. Author information Abstract Diacylglycerol lipase (DAGL) α and β, the major biosynthetic enzymes of the endogenous cannabinoid (endocannabinoid) 2-arachidonylglycerol (2-AG), are highly expressed in the nervous […]

From Structure-Activity Relationships on Thiazole Derivatives to the In Vivo Evaluation of a New Radiotracer for Cannabinoid Subtype 2 PET Imaging.

Mol Pharm. 2017 Oct 2. doi: 10.1021/acs.molpharmaceut.7b00746. [Epub ahead of print] Caillé F, Cacheux F, Peyronneau MA, Jego B, Jaumain E, Pottier G, Ullmer C, Grether U, Winkeler A, Dollé F, Damont A, Kuhnast B. Abstract Upregulation of the cannabinoid type 2 receptors (CB2R) unveils inflammation processes of pathological disorders such as cancer, pain or […]

Is cannabis an effective treatment for joint pain?

Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):59-67. Epub 2017 Sep 28. Miller RJ1, Miller RE2. Author information Abstract Cannabis has been used to treat pain for thousands of years. However, since the early part of the 20th century, laws restricting cannabis use have limited its evaluation using modern scientific criteria. Over the last decade, the […]

Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.

Proc Natl Acad Sci U S A. 2017 Oct 2. pii: 201711351. doi: 10.1073/pnas.1711351114. [Epub ahead of print] Kaplan JS1, Stella N1,2, Catterall WA3, Westenbroek RE1. Author information Abstract Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its efficacy from preclinical and clinical studies. Here we show that cannabidiol (CBD) effectively […]