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Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence.

J Neurol Neurosurg Psychiatry. 2018 Mar 6. pii: jnnp-2017-317168. doi: 10.1136/jnnp-2017-317168. [Epub ahead of print] Stockings E1, Zagic D1, Campbell G1, Weier M1, Hall WD2,3, Nielsen S1, Herkes GK4, Farrell M1, Degenhardt L1. Author information Abstract Review evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Systematic search of Medline, Embase and PsycINFO was conducted […]

Leveraging user perspectives for insight into cannabis concentrates.

Am J Drug Alcohol Abuse. 2018 Mar 7:1-14. doi: 10.1080/00952990.2018.1436179. [Epub ahead of print] Cavazos-Rehg PA1, Krauss MJ1, Sowles SJ1, Floyd GM1, Cahn ES1, Chaitan VL1, Ponton M1. Author information Abstract BACKGROUND: The US has seen an increase in the popularity of highly concentrated forms of cannabis (hereafter concentrates) and too little is known about […]

A stimulus-responsive, in situ-forming, nanoparticle-laden hydrogel for ocular drug delivery.

Drug Deliv Transl Res. 2018 Mar 5. doi: 10.1007/s13346-018-0504-x. [Epub ahead of print] Kabiri M1,2, Kamal SH1, Pawar SV1, Roy PR1, Derakhshandeh M1,3, Kumar U4, Hatzikiriakos SG1, Hossain S5, Yadav VG6,7. Author information Abstract Most medications targeting optic neuropathies are administered as eye drops. However, their corneal penetration efficiencies are typically < 5%. There is a […]

Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures.

Metab Brain Dis. 2018 Mar 4. doi: 10.1007/s11011-018-0195-5. [Epub ahead of print] Zareie P1, Sadegh M2, Palizvan MR1, Moradi-Chameh H3. Author information Abstract 2-Arachidonoylglycerol (2-AG) and anandamide are two major endocannabinoids produced, released and eliminated by metabolic pathways. Anticonvulsive effect of 2-AG and CB1 receptor is well-established. Herein, we designed to investigate the anticonvulsive influence […]

[Beneficial Effect of Medical Cannabis in the Treatment of a Pharmacoresistant Nausea Associated with a Somatoform Disorder in a Patient with Post-Polio Syndrome].

Dtsch Med Wochenschr. 2018 Mar;143(5):344-348. doi: 10.1055/s-0043-123897. Epub 2018 Mar 5. [Article in German; Abstract available in German from the publisher] Bleckwenn M1, Weckbecker K1, Voss S1. Author information Abstract in English, German HISTORY AND CLINICAL FINDINGS: We report a 79-year-old patient with post-polio syndrome (PPS). In the course of this disease, recurrent upper abdominal […]

The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling.

Neuropharmacology. 2018 Mar 3. pii: S0028-3908(18)30102-3. doi: 10.1016/j.neuropharm.2018.03.001. [Epub ahead of print] Fogaça MV1, de Campos AC2, Coelho LD2, Duman RS3, Guimarães FS2. Author information Abstract Repeated injections of cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, attenuate the anxiogenic effects induced by Chronic Unpredictable Stress (CUS). The specific mechanisms remain […]

Inhibition of 2-arachydonoylgycerol degradation attenuates orofacial neuropathic pain in trigeminal nerve-injured mice.

J Oral Sci. 2018 Mar 2. doi: 10.2334/josnusd.17-0005. [Epub ahead of print] Kamimura R1, Hossain MZ2, Unno S2, Ando H3, Masuda Y4, Takahashi K1, Otake M1, Saito I1, Kitagawa J2. Author information Abstract Current therapeutics are not effective for orofacial neuropathic pain, and better options are needed. The present study used inferior orbital nerve (ION)-injured […]

Self-medication of mood and anxiety disorders with marijuana: Higher in states with medical marijuana laws.

Drug Alcohol Depend. 2018 Mar 2;186:10-15. doi: 10.1016/j.drugalcdep.2018.01.009. [Epub ahead of print] Sarvet AL1, Wall MM2, Keyes KM3, Olfson M1, Cerdá M4, Hasin DS5. Author information Abstract BACKGROUND: Self-medication with drugs or alcohol is commonly reported among adults with mood or anxiety disorders, and increases the risk of developing substance use disorders. Medical marijuana laws […]

Clinical Challenges in the Growing Medical Marijuana Field.

R I Med J (2013). 2018 Mar 1;101(2):12-13. Barker J1. Author information Abstract Unique clinical challenges arise with the growing number of patients who possess medical marijuana cards. Medical marijuana patients with mental disorders can have worsening symptoms with marijuana use. Often there is sparse continuity of care between the patient and the medical marijuana […]

Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets.

Diabetologia. 2018 Mar 1. doi: 10.1007/s00125-018-4576-4. [Epub ahead of print] González-Mariscal I1, Montoro RA1, Doyle ME1, Liu QR1, Rouse M1, O’Connell JF1, Santa-Cruz Calvo S1, Krzysik-Walker SM1, Ghosh S1, Carlson OD1, Lehrmann E2, Zhang Y2, Becker KG2, Chia CW3, Ghosh P1, Egan JM4. Author information Abstract AIMS/HYPOTHESIS: The cannabinoid 1 receptor (CB1R) regulates insulin sensitivity […]