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A Review of Adjunctive CNS Medications Used for the Treatment of Post-Surgical Pain.

CNS Drugs. 2017 Jun 2. doi: 10.1007/s40263-017-0440-1. [Epub ahead of print] Rai A1, Meng H1,2, Weinrib A2,3,4, Englesakis M5, Kumbhare D6, Grosman-Rimon L6, Katz J1,2,4, Clarke H7,8,9. Author information Abstract Inadequate post-operative pain management can have significant impacts on patients’ quality of life. Effective management of acute pain after surgery is important for early mobilization […]

Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits.

Neuropharmacology. 2017 Jun 1. pii: S0028-3908(17)30258-7. doi: 10.1016/j.neuropharm.2017.05.033. [Epub ahead of print] Lau BK1, Cota D2, Cristino L3, Borgland SL4. Author information Abstract The endocannabinoid system has emerged as a key player in the control of eating. Endocannabinoids, including 2-arachidonoylglycerol (2-AG) and anandamide (AEA), modulate neuronal activity via cannabinoid 1 receptors (CB1Rs) in multiple nuclei […]

Marijuana Use in the Elderly: Implications and Considerations.

Consult Pharm. 2017 Jun 1;32(6):341-351. doi: 10.4140/TCP.n.2017.341. Mahvan TD, Hilaire ML, Mann A, Brown A, Linn B, Gardner T, Lai B. Abstract OBJECTIVE: This article reviews the literature on the use of marijuana in the elderly. Pharmacists play an important role in the management of medications including drug use of potentially illegal drugs, including marijuana. […]

Biodegradation of Phenol and Benzene by Endophytic Bacterial Strains Isolated from Refinery Wastewater-Fed Cannabis sativa.

Environ Technol. 2017 May 31:1-35. doi: 10.1080/09593330.2017.1337232. [Epub ahead of print] Iqbal A1,2,3, Arshad M1, Hashmi I1, Karthikeyan R2, Gentry TJ3, Schwab AP3. Author information Abstract Presence of benzene and phenol in the environment can lead to serious health effects in humans. Development of efficient cleanup strategies for these pollutants is of significant importance. The […]

Cannabinoid CB1/CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-based anorexia.

Br J Pharmacol. 2017 May 31. doi: 10.1111/bph.13892. [Epub ahead of print] Scherma M1, Satta V1, Collu R1, Boi MF2, Usai P2, Fratta W1,3, Fadda P1,3. Author information Abstract BACKGROUND AND PURPOSE: Anorexia nervosa (AN) is a serious psychiatric condition characterized by excessive body weight loss and disturbed perceptions of body shape and size, often […]

Zonisamide ameliorates levodopa-induced dyskinesia and reduces expression of striatal genes in Parkinson model rats.

Neurosci Res. 2017 May 31. pii: S0168-0102(17)30063-9. doi: 10.1016/j.neures.2017.04.003. [Epub ahead of print] Oki M1, Kaneko S2, Morise S1, Takenouchi N3, Hashizume T4, Tsuge A1, Nakamura M1, Wate R1, Kusaka H1. Author information Abstract To investigate the difference in results according to the mode of levodopa administration and the effect of zonisamide (ZNS), we analyzed […]

Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis.

Pain. 2017 May 31. doi: 10.1097/j.pain.0000000000000966. [Epub ahead of print] Uhelski ML1, Gupta K, Simone DA. Author information Abstract Chronic pain and hyperalgesia, as well as pain resulting from episodes of vasoocclusion, are characteristic features of sickle cell disease (SCD) and are difficult to treat. Since there is growing evidence that increasing local levels of […]

The Cannabis Information Helpline: Assessing Interest in the Medicinal Use of Cannabis in Australia.

Subst Use Misuse. 2017 May 30:1-5. doi: 10.1080/10826084.2017.1298616. [Epub ahead of print] Gates PJ1, Albertella L1. Author information Abstract BACKGROUND: The majority of Australians support a change in legislation to allow the use of cannabis for medical purposes. Despite strong public support, very little is known about the patterns of medicinal cannabis use among Australians. […]

Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation.

Neurosci Biobehav Rev. 2017 May 30. pii: S0149-7634(17)30088-X. doi: 10.1016/j.neubiorev.2017.05.022. [Epub ahead of print] de la Tremblaye PB1, O’Neil DA1, LaPorte MJ1, Cheng JP1, Beitchman JA2, Thomas TC3, Bondi CO4, Kline AE5. Author information Abstract The aim of this review is to discuss the research presented in a symposium entitled “Current progress in characterizing therapeutic […]

Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress.

Drug Alcohol Depend. 2017 May 30;177:136-144. doi: 10.1016/j.drugalcdep.2017.03.030. [Epub ahead of print] Childs E1, Lutz JA2, de Wit H2. Author information Abstract OBJECTIVES: Cannabis smokers often report that they use the drug to relax or to relieve emotional stress. However, few clinical studies have shown evidence of the stress-relieving effects of cannabis or cannabinoid agonists. […]