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cannabinoid enthusiasts always welcome

The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: clues for other neuroinflammatory diseases.

Prog Neurobiol. 2017 Oct 30. pii: S0301-0082(17)30070-9. doi: 10.1016/j.pneurobio.2017.10.007. [Epub ahead of print] Chiurchiù V1, van der Stelt M2, Centonze D3, Maccarrone M4. Author information Abstract Multiple sclerosis is the most common inflammatory demyelinating disease of the central nervous system, caused by an autoimmune response against myelin that eventually leads to progressive neurodegeneration and disability. […]

Combined deficiency of the Cnr1 and Cnr2 receptors protects against age-related bone loss by osteoclast inhibition.

Aging Cell. 2017 Jul 28. doi: 10.1111/acel.12638. [Epub ahead of print] Sophocleous A1,2,3, Marino S1,4, Kabir D1, Ralston SH2, Idris AI1,4. Author information Abstract The endocannabinoid system plays a role in regulating bone mass and bone cell activity and inactivation of the type 1 (Cnr1) or type 2 (Cnr2) cannabinoid receptors influences peak bone mass […]

Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression.

PLoS One. 2017 Jul 27;12(7):e0182141. doi: 10.1371/journal.pone.0182141. eCollection 2017. Zhang Y1, Kim DK1, Lu Y2, Jung YS1, Lee JM1, Kim YH3, Lee YS1, Kim J4, Dewidar B5, Jeong WI6, Lee IK7,8, Cho SJ4,8, Dooley S5, Lee CH3, Li X2, Choi HS1. Author information Abstract Fibrinogen, 1 of 13 coagulation factors responsible for normal blood clotting, […]

Cannabinoids and the Kidney: Effects in Health and Disease.

Am J Physiol Renal Physiol. 2017 Jul 26:ajprenal.00290.2017. doi: 10.1152/ajprenal.00290.2017. [Epub ahead of print] Park F1, Potukuchi PK2, Moradi H3, Kovesdy CP4. Author information Abstract Consumption of cannabis and various related products (cannabinoids) for both medicinal and recreational use is gaining popularity. Furthermore, regulatory changes are fostering a cultural shift towards increasing liberalization of cannabis […]

Cannabis may have positive impacts on mood, memory, fatigue, and obesity status in people with PD and MS.

An anonymous web-based survey was hosted on the Michael J. Fox Foundation and the National Multiple Sclerosis Society webpages from 15 February to 15 October 2016. In this survey they collected demographic and cannabis use information, and used standardized questionnaires to assess neurological function, fatigue, balance, and physical activity participation. The survey was viewed 801 times, and […]

Cannabis use in people with Parkinson’s disease and Multiple Sclerosis: A web-based investigation.

Complement Ther Med. 2017 Aug;33:99-104. doi: 10.1016/j.ctim.2017.07.002. Epub 2017 Jul 10. Kindred JH1, Li K2, Ketelhut NB3, Proessl F4, Fling BW5, Honce JM6, Shaffer WR7, Rudroff T8. Author information Abstract OBJECTIVES: Cannabis has been used for medicinal purpose for thousands of years; however the positive and negative effects of cannabis use in Parkinson’s disease (PD) […]

Cannabis Guidelines

Clin J Oncol Nurs. 2017 Aug 1;21(4):409. doi: 10.1188/17.CJON.409. Kennedy Sheldon L1. Author information Abstract Cannabis has been used for centuries in the treatment of medical conditions. Cannabis has been recommended for appetite, anxiety, depression, sleep, and migraines. However, the stigma associated with cannabis as a recreational drug has created challenges to the legitimacy and […]

New Methods for the Synthesis of Cannabidiol Derivatives.

Methods Enzymol. 2017;593:237-257. doi: 10.1016/bs.mie.2017.05.006. Epub 2017 Jul 3. Lago-Fernandez A1, Redondo V1, Hernandez-Folgado L1, Figuerola-Asencio L1, Jagerovic N2. Author information Abstract Cannabidiol (CBD) is one of the most abundant components isolated from Cannabis sativa. However, CBD is a nonpsychotropic phytocannabinoid. In the last decade, there has been a growing interest in its therapeutic effects. […]

Interventions for Neuropathic Pain: An Overview of Systematic Reviews.

Anesth Analg. 2017 Aug;125(2):643-652. doi: 10.1213/ANE.0000000000001998. Dosenovic S1, Jelicic Kadic A, Miljanovic M, Biocic M, Boric K, Cavar M, Markovina N, Vucic K, Puljak L. Author information Abstract Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains unsatisfactory. We systematically summarized evidence from systematic reviews (SRs) of randomized controlled trials on interventions […]

Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors.

Mol Neurobiol. 2017 Jul 21. doi: 10.1007/s12035-017-0689-x. [Epub ahead of print] Zhang J1, Chen C2,3. Author information Abstract Inhibition of monoacylglycerol lipase (MAGL), the primary enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain, produces profound anti-inflammatory and neuroprotective effects and improves synaptic and cognitive functions in animal models of Alzheimer’s disease (AD). However, […]