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cannabinoid enthusiasts always welcome

Cannabis for paediatric epilepsy: challenges and conundrums.

Med J Aust. 2018 Feb 19;208(3):132-136. Chen KA1, Farrar MA2, Cardamone M2, Lawson JA2. Author information Abstract Research is expanding for the use of cannabidiol as an anticonvulsant drug. The mechanism of cannabidiol in paediatric epilepsy is unclear but is thought to play a role in modulation of synaptic transmission. Evidence for its efficacy in […]

Regulating Cannabis Manufacturing: Applying Public Health Best Practices from Tobacco Control.

J Psychoactive Drugs. 2018 Feb 13:1-14. doi: 10.1080/02791072.2017.1422816. [Epub ahead of print] Orenstein DG1, Glantz SA2. Author information Abstract State legalization and regulation of cannabis, despite continued federal illegality, is a massive shift in regulatory approach. Manufactured cannabis, including concentrates, extracts, edibles, tinctures, topicals and other products, has received less attention than more commonly used […]

Plasma N-acylethanolamine and endocannabinoid levels in burning mouth syndrome: potential role in disease pathogenesis.

J Oral Pathol Med. 2018 Feb 13. doi: 10.1111/jop.12692. [Epub ahead of print] Barry A1, O’Halloran KD1, McKenna JP2, McCreary C2, Harhen B3,4, Kerr DM3,4, Finn DP3,4, Downer EJ5. Author information Abstract OBJECTIVE: The objective was to measure endocannabinoid (eCB) ligands and non-cannabinoid N-acylethanolamine (NAE) molecules in plasma from individuals with burning mouth syndrome (BMS), […]

Ultrasound-Assisted Extraction of Cannabinoids from Cannabis Sativa L. Optimized by Response Surface Methodology.

J Food Sci. 2018 Feb 13. doi: 10.1111/1750-3841.14075. [Epub ahead of print] Agarwal C1, Máthé K2, Hofmann T3, Csóka L1. Author information Abstract Ultrasonication was used to extract bioactive compounds from Cannabis sativa L. such as polyphenols, flavonoids, and cannabinoids. The influence of 3 independent factors (time, input power, and methanol concentration) was evaluated on […]

Cannabis use is associated with lower rates of initiation of injection drug use among street-involved youth: A longitudinal analysis.

Drug Alcohol Rev. 2018 Feb 12. doi: 10.1111/dar.12667. [Epub ahead of print] Reddon H1,2, DeBeck K1,3, Socias ME1,4, Dong H1, Wood E1,4, Montaner J1,4, Kerr T1,4, Milloy MJ1,4. Author information Abstract INTRODUCTION AND AIMS: Street-involved youth are known to be at elevated risk of initiating injection drug use. However, the impact of so-called ‘gateway’ drugs, […]

Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims.

Neurotherapeutics. 2018 Feb 12. doi: 10.1007/s13311-018-0610-y. [Epub ahead of print] García-Gutiérrez MS1,2, Navarrete F1,2, Navarro G3,4, Reyes-Resina I3,4, Franco R3,4, Lanciego JL4,5, Giner S6, Manzanares J7,8. Author information Abstract Recent studies point to the cannabinoid CB2 receptors (CB2r) and the non-cannabinoid receptor GPR55 as potential key targets involved in the response to stress, anxiety, and […]

Changes in the Peripheral Endocannabinoid System as a Risk Factor for the Development of Eating Disorders.

Endocr Metab Immune Disord Drug Targets. 2018 Feb 12. doi: 10.2174/1871530318666180213112406. [Epub ahead of print] Capasso A1, Milano W2, Cauli O3. Author information Abstract BACKGROUND AND OBJECTIVE: Eating Disorder (ED) is characterized by persistently and severely disturbed eating behaviours. They arise from a combination of long-standing behavioural, emotional, psychological, interpersonal, and social factors and result […]

Involvement of spinal cannabinoid receptors in the antipruritic effects of WIN 55,212-2, a cannabinoid receptor agonist.

Clin Exp Dermatol. 2018 Feb 9. doi: 10.1111/ced.13398. [Epub ahead of print] Bilir KA1, Anli G1, Ozkan E1, Gunduz O1, Ulugol A1. Author information Abstract BACKGROUND: Cannabinoids have been used for their analgesic and euphoric effects for millennia, but recently the antipruritic effects of cannabis have been discovered. Considering the similarities between pain and itch […]

Learning and Memory is Modulated by Cannabidiol When Administered During Trace Fear-Conditioning.

Neurobiol Learn Mem. 2018 Feb 9. pii: S1074-7427(18)30022-4. doi: 10.1016/j.nlm.2018.02.009. [Epub ahead of print] Uhernik AL1, Montoya ZT1, Balkissoon CD1, Smith JP2. Author information Abstract Cannabidiol (CBD) is thought to have therapeutic potential for treating psychiatric conditions that affect cognitive aspects of learning and memory, including anxiety and post-traumatic stress disorder (PTSD). Studies have shown […]

Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center.

Epilepsy Behav. 2018 Feb 8. pii: S1525-5050(18)30009-X. doi: 10.1016/j.yebeh.2018.01.026. [Epub ahead of print] Porcari GS1, Fu C2, Doll ED2, Carter EG2, Carson RP3. Author information Abstract Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately 1 in 3 patients continues to have seizures. Cannabidiol (CBD), one […]