Archive by Author

Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review.

Ann Intern Med. 2017 Aug 15. doi: 10.7326/M17-0477. [Epub ahead of print] O’Neil ME1, Nugent SM1, Morasco BJ1, Freeman M1, Low A1, Kondo K1, Zakher B1, Elven C1, Motu’apuaka M1, Paynter R1, Kansagara D1. Author information Abstract BACKGROUND: Cannabis is available from medical dispensaries for treating posttraumatic stress disorder (PTSD) in many states of the […]

Propagating the Haze? Community and professional perceptions of cannabis cultivation and the impacts of prohibition.

Int J Drug Policy. 2017 Aug 12;48:72-80. doi: 10.1016/j.drugpo.2017.07.015. [Epub ahead of print] Beckett Wilson H1, Taylor S2, Barrett G3, Jamieson J4, Grindrod L5. Author information Abstract BACKGROUND: Recent decades have seen substantial changes in the UK cannabis landscape, including increased domestic production, the ascendancy of stronger strains (namely ‘skunk’) and the drug‘s reclassification under […]

Marijuana and Cannabinoids in ESRD and Earlier Stages of CKD.

Am J Kidney Dis. 2017 Aug 12. pii: S0272-6386(17)30810-7. doi: 10.1053/j.ajkd.2017.06.020. [Epub ahead of print] Rein JL1, Wyatt CM2. Author information Abstract Marijuana is the most commonly used recreational drug in the United States, and legal recreational and medicinal use has gained public acceptance during the last decade. Twenty-nine US states have established medical marijuana […]

Neuroprotective activity of cannabinoid receptor-2 against oxidative stress and apoptosis in rat pups having experimentally-induced congenital hypothyroidism.

Dev Neurobiol. 2017 Aug 11. doi: 10.1002/dneu.22516. [Epub ahead of print] Alcigir ME1, Dogan HO2, Vural SA1, Yilmaz FM3. Author information Abstract In this study, it was aimed to show the cannabinoid receptor-2 (CB2) role, which is a part of neuroprotective endocannabinoidal system, against increasing nitric oxide synthetase (iNOS, eNOS) levels and the apoptotic activity […]

GPR55: A therapeutic target for Parkinson’s disease?

Neuropharmacology. 2017 Aug 11. pii: S0028-3908(17)30384-2. doi: 10.1016/j.neuropharm.2017.08.017. [Epub ahead of print] Celorrio M1, Rojo-Bustamante E1, Fernández-Suárez D2, Sáez E3, Estella-Hermoso de Mendoza A3, Müller CE4, Ramírez MJ5, Oyarzábal J3, Franco R6, Aymerich MS7. Author information Abstract The GPR55 receptor is expressed abundantly in the brain, especially in the striatum, suggesting it might fulfill a […]

The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.

Mol Brain. 2017 Aug 11;10(1):38. doi: 10.1186/s13041-017-0318-7. Shi QX1, Yang LK1, Shi WL2, Wang L1, Zhou SM1, Guan SY1, Zhao MG1, Yang Q3,4. Author information Abstract The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by […]

A Review of the Therapeutic Antitumor Potential of Cannabinoids.

J Altern Complement Med. 2017 Aug 11. doi: 10.1089/acm.2017.0016. [Epub ahead of print] Bogdanović V1, Mrdjanović J1, Borišev I2. Author information Abstract OBJECTIVES: The aim of this review is to discuss cannabinoids from a preclinical and clinical oncological perspective and provide the audience with a concise, retrospective overview of the most significant findings concerning the […]

Effects of smoked marijuana in experimentally induced asthma.

Am Rev Respir Dis. 1975 Sep;112(3):377-86. Tashkin DP, Shapiro BJ, Lee YE, Harper CE. Abstract After experimental induction of acute bronchospasm in 8 subjects with clinically stable bronchial asthma, effects of 500 mg of smoked marijuana (2.0 per cent delta9-tetrahydrocannabinol) on specific airway conductance and thoracic gas volume were compared with those of 500 mg […]

Cannabis phenolics and their bioactivities.

Curr Med Chem. 2017 Aug 10. doi: 10.2174/0929867324666170810164636. [Epub ahead of print] Pollastro F1, Minassi A1, Fresu LG2. Author information Abstract Although Cannabis sativa L. is one of the most versatile plant species with multipurpose use both as medical, alimentary source and as psychoactive abuse, its biomedical relevance focused the attention on major cannabinoids. Phytochemical […]

Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients.

Int J Mol Sci. 2017 Aug 10;18(8). pii: E1739. doi: 10.3390/ijms18081739. Jakubovski E1, Müller-Vahl K2. Author information Abstract We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical […]