Archive by Author

Chemical Tools for Studying Lipid-Binding Class A G Protein-Coupled Receptors.

Pharmacol Rev. 2017 Jul;69(3):316-353. doi: 10.1124/pr.116.013243. Cooper A1, Singh S1, Hook S1, Tyndall JDA1, Vernall AJ2. Author information Abstract Cannabinoid, free fatty acid, lysophosphatidic acid, sphingosine 1-phosphate, prostanoid, leukotriene, bile acid, and platelet-activating factor receptor families are class A G protein-coupled receptors with endogenous lipid ligands. Pharmacological tools are crucial for studying these receptors and […]

Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

Neuropsychopharmacology. 2017 Jun 27. doi: 10.1038/npp.2017.130. [Epub ahead of print] Hillard CJ1. Author information Abstract The goal of this review is to summarize studies in which concentrations of circulating endocannabinoids in humans have been examined in relationship to physiological measurements and pathological status. The roles of endocannabinoids in the regulation of energy intake and storage […]

Incretin Secretion in Humans is under the Influence of Cannabinoid Receptors.

Am J Physiol Endocrinol Metab. 2017 Jun 27:ajpendo.00080.2017. doi: 10.1152/ajpendo.00080.2017. [Epub ahead of print] Chia CW1, Carlson OD2, Liu DD2, González-Mariscal I2, Santa-Cruz Calvo S2, Egan JM2. Author information Abstract The mechanisms regulating incretin secretion are not fully known. Human obesity is associated with altered incretin secretion and elevated endocannabinoid levels. Since cannabinoid receptors (CBRs) […]

Unity – Community – Cannabis & Love

Friday set the scene for the after party of Winnipeg’s first Unity Cup which followed the Meet and Greet held earlier at WEEDS Glass & Gifts. Those in attendance also celebrated Mat M’s. of WEEDS Winnipeg’s 50th birthday! Happy Birthday Mat!!! The after party at Nectars Nightclub was a yabbin’ dabbin’ due time! OneLove. Over 275 tickets were sold […]

Commentary: Navigating the complexities of marijuana.

Prev Med. 2017 Jun 23. pii: S0091-7435(17)30230-X. doi: 10.1016/j.ypmed.2017.06.026. [Epub ahead of print] Weiss S1, Wargo EM2. Author information Abstract Science needs to drive our thinking as we navigate a new legislative environment in which many Americans have access to marijuana for therapeutic or recreational use. With the responsibility to fund, conduct, and make use […]

Fundamentals of and Critical Issues in Lipid Autacoid Medicine: A Review.

Pain Ther. 2017 Jun 19. doi: 10.1007/s40122-017-0075-4. [Epub ahead of print] Keppel Hesselink JM1. Author information Abstract The identification of a number of families of lipid signal molecules since the 1990s created new therapeutic possibilities for a great number of disorders characterized by chronic inflammation and pain. These lipid autacoids have been explored in a […]

Changes in hemp secondary fiber production related to technical fiber variability revealed by light microscopy and attenuated total reflectance Fourier transform infrared spectroscopy.

PLoS One. 2017 Jun 22;12(6):e0179794. doi: 10.1371/journal.pone.0179794. eCollection 2017. Fernandez-Tendero E1,2,3, Day A2,3, Legros S4, Habrant A1, Hawkins S2, Chabbert B1. Author information Abstract Interest in hemp (Cannabis sativa L.) is increasing due to the development of a new range of industrial applications based on bast fibers. However the variability of bast fiber yield and […]

Cannabinoids in Pediatrics.

J Pediatr Pharmacol Ther. 2017 May-Jun;22(3):176-185. doi: 10.5863/1551-6776-22.3.176. Campbell CT, Phillips MS, Manasco K. Abstract Despite its controversial nature, the use of medical marijuana and cannabis-derived medicinal products grows more popular with each passing year. As of November 2016, over 40 states have passed legislation regarding the use of either medical marijuana or cannabidiol products. […]

ESSENTIAL DIETARY BIOACTIVE LIPIDS IN NEUROINFLAMMATORY DISEASES.

Antioxid Redox Signal. 2017 Jun 22. doi: 10.1089/ars.2016.6958. [Epub ahead of print] Catani MV1, Gasperi V2, Bisogno T3,4, Maccarrone M5,6. Author information Abstract Under physiological conditions, neurons and glia are in a healthy, redox-balanced environment; when injury perturbs this equilibrium, a neuroinflammatory state is established by activated microglia that triggers pro-inflammatory responses and alters the […]

A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.

EMBO J. 2017 Jun 21. pii: e201695347. doi: 10.15252/embj.201695347. [Epub ahead of print] Malenczyk K1,2, Girach F1, Szodorai E1, Storm P3, Segerstolpe Å4, Tortoriello G2, Schnell R5, Mulder J6, Romanov RA1,2, Borók E7, Piscitelli F8, Di Marzo V8, Szabó G9, Sandberg R4, Kubicek S10, Lubec G11, Hökfelt T2, Wagner L12, Groop L3, Harkany T13,2. Author […]