Amplification of mGlu5-endocannabinoid signaling rescues behavioral and synaptic deficits in a mouse model of adolescent and adult dietary polyunsaturated fatty acids imbalance.

J Neurosci. 2017 Jun 19. pii: 3516-16. doi: 10.1523/JNEUROSCI.3516-16.2017. [Epub ahead of print] Manduca A1,2,3, Bara A1,2,3, Larrieu T4,5, Lassalle O1,2,3, Joffre C4,5, Layé S4,5, Manzoni OJ6,2,3. Author information Abstract Energy-dense, yet nutritionally-poor food is a high-risk factor for mental health disorders. This is of particular concern during adolescence, a period often associated with increased […]

The Use of Cannabinoids in Treating Dementia

Buy options Current Neurology and Neuroscience Reports August 2017, 17:56 Authors Authors and affiliations Megan Weier Wayne HallEmail author Dementia (K Marder, Section Editor) First Online: 19 June 2017 DOI: 10.1007/s11910-017-0766-6 Cite this article as: Weier, M. & Hall, W. Curr Neurol Neurosci Rep (2017) 17: 56. doi:10.1007/s11910-017-0766-6 Part of the following topical collections: Topical Collection on […]

The case for cannabinoid CB1 receptors as a target for bronchodilator therapy for β-agonist resistant asthma.

Curr Drug Targets. 2017 Jun 15. doi: 10.2174/1389450118666170615101220. [Epub ahead of print] Ashton J1, Hancox RJ2. Author information Abstract Although b2-receceptor agonists are powerful bronchodilators and are at the forefront of asthma symptom relief, patients who use them frequently develop partial resistance to them. This can be a particularly serious problem during severe attacks, where […]

Synaptic functions of endocannabinoid signaling in health and disease.

Neuropharmacology. 2017 Jun 15. pii: S0028-3908(17)30286-1. doi: 10.1016/j.neuropharm.2017.06.017. [Epub ahead of print] Araque A1, Castillo PE2, Manzoni OJ3, Tonini R4. Author information Abstract Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of synaptic transmission and plasticity. They are synthetized “on demand” following physiological and/or pathological stimuli. Once released from postsynaptic […]

The cannabinoid system and pain.

Neuropharmacology. 2017 Jun 15. pii: S0028-3908(17)30285-X. doi: 10.1016/j.neuropharm.2017.06.015. [Epub ahead of print] Woodhams SG1, Chapman V2, Finn DP3, Hohmann AG4, Neugebauer V5. Author information Abstract Chronic pain states are highly prevalent and yet poorly controlled by currently available analgesics, representing an enormous clinical, societal, and economic burden. Existing pain medications have significant limitations and adverse […]

Assessing the role of serotonergic receptors in cannabidiol’s anticonvulsant efficacy.

Epilepsy Behav. 2017 Jun 15;73:111-118. doi: 10.1016/j.yebeh.2017.04.045. [Epub ahead of print] Pelz MC1, Schoolcraft KD2, Larson C3, Spring MG4, López HH5. Author information Abstract Cannabidiol (CBD) is a phytocannabinoid that has demonstrated anticonvulsant efficacy in several animal models of seizure. The current experiment validated CBD’s anticonvulsant effect using the acute pentylenetetrazol (PTZ) model. Furthermore, it […]

Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol.

Epilepsia. 2017 Jun 15. doi: 10.1111/epi.13815. [Epub ahead of print] Rosenberg EC1, Louik J2, Conway E2, Devinsky O2, Friedman D2. Author information Abstract Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many of these patients experience significant impairments in quality of life (QOL) […]

A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.

JCI Insight. 2017 Jun 15;2(12). pii: 93760. doi: 10.1172/jci.insight.93760. [Epub ahead of print] Jadoon KA1, Tan GD2, O’Sullivan SE1. Author information Abstract BACKGROUND: Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid used in multiple sclerosis and intractable epilepsies. Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced blood pressure (BP) response to stress. The aim […]

Inhibitory effect of trans-caryophyllene (TC) on leukocyte-endothelial attachment.

Toxicol Appl Pharmacol. 2017 Jun 14. pii: S0041-008X(17)30272-7. doi: 10.1016/j.taap.2017.06.016. [Epub ahead of print] Zhang Z1, Yang C1, Dai X2, Ao Y1, Li Y3. Author information Abstract trans-Caryophyllene (TC) is a major component found in the essential oils of many spices and foods/medicinal plants. It is a natural sesquiterpene and has been the subject of […]

Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders.

Neuroscience. 2017 Jun 14. pii: S0306-4522(17)30413-X. doi: 10.1016/j.neuroscience.2017.06.015. [Epub ahead of print] Korem N1, Lange R2, Hillard CJ2, Akirav I3. Author information Abstract The response to a traumatic experience may be rapid recovery or development of psychopathology such as posttraumatic stress disorder (PTSD). Impaired extinction of fear memories is thought to contribute to the development […]