A Review of the Therapeutic Antitumor Potential of Cannabinoids.

J Altern Complement Med. 2017 Aug 11. doi: 10.1089/acm.2017.0016. [Epub ahead of print] Bogdanović V1, Mrdjanović J1, Borišev I2. Author information Abstract OBJECTIVES: The aim of this review is to discuss cannabinoids from a preclinical and clinical oncological perspective and provide the audience with a concise, retrospective overview of the most significant findings concerning the […]

Effects of smoked marijuana in experimentally induced asthma.

Am Rev Respir Dis. 1975 Sep;112(3):377-86. Tashkin DP, Shapiro BJ, Lee YE, Harper CE. Abstract After experimental induction of acute bronchospasm in 8 subjects with clinically stable bronchial asthma, effects of 500 mg of smoked marijuana (2.0 per cent delta9-tetrahydrocannabinol) on specific airway conductance and thoracic gas volume were compared with those of 500 mg […]

Cannabis phenolics and their bioactivities.

Curr Med Chem. 2017 Aug 10. doi: 10.2174/0929867324666170810164636. [Epub ahead of print] Pollastro F1, Minassi A1, Fresu LG2. Author information Abstract Although Cannabis sativa L. is one of the most versatile plant species with multipurpose use both as medical, alimentary source and as psychoactive abuse, its biomedical relevance focused the attention on major cannabinoids. Phytochemical […]

Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients.

Int J Mol Sci. 2017 Aug 10;18(8). pii: E1739. doi: 10.3390/ijms18081739. Jakubovski E1, Müller-Vahl K2. Author information Abstract We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical […]

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution.

J Med Chem. 2017 Aug 9. doi: 10.1021/acs.jmedchem.7b00707. [Epub ahead of print] Nguyen T, German N, Decker AM, Langston TL, Gamage TF, Farquhar CE, Li JX, Wiley JL, Thomas BF, Zhang Y. Abstract Allosteric modulators of the cannabinoid CB1 receptor have recently been reported as an alternative approach to modulate the CB1 receptor for therapeutic […]

Modulation of GABAA receptors in the treatment of epilepsy.

Curr Pharm Des. 2017 Aug 9. doi: 10.2174/1381612823666170809100230. [Epub ahead of print] Palma E1, Ruffolo G1, Cifelli P2, Roseti C3, van Vliet EA4, Aronica E4. Author information Abstract BACKGROUND: A variety of evidence suggested that an imbalance in excitatory and inhibitory neurotransmission could be one of the pathophysiological mechanisms underlying the occurrence and progression of […]

Effects of Cannabidiol on Morphine Conditioned Place Preference in Mice.

Planta Med. 2017 Aug 9. doi: 10.1055/s-0043-117838. [Epub ahead of print] Markos JR1, Harris HM1, Gul W2,3, ElSohly MA2,4,3, Sufka KJ1,2. Author information Abstract This study sought to determine whether the cannabis constituent cannabidiol attenuates the development of morphine reward in the conditioned place preference paradigm. Separate groups of mice received either saline or morphine […]

Antiepileptic drugs in clinical development: differentiate or die?

Curr Pharm Des. 2017 Aug 9. doi: 10.2174/1381612823666170809100524. [Epub ahead of print] Zaccara G1, Schmidt D2. Author information Abstract BACKGROUND: Animal models when carefully selected, designed and conducted, are important parts of any translational drug development strategy. However, research of new compounds for patients with drug-resistant epilepsies is still based on animal experiments, mostly in […]

Structural barriers in access to medical marijuana in the USA-a systematic review protocol.

Syst Rev. 2017 Aug 7;6(1):154. doi: 10.1186/s13643-017-0541-4. Valencia CI1, Asaolu IO2, Ehiri JE2, Rosales C3. Author information Abstract BACKGROUND: There are 43 state medical marijuana programs in the USA, yet limited evidence is available on the demographic characteristics of the patient population accessing these programs. Moreover, insights into the social and structural barriers that inform […]

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men.

Sci Rep. 2017 Aug 8;7(1):7558. doi: 10.1038/s41598-017-07980-5. Kantae V1, Nahon KJ2,3, Straat ME2,3, Bakker LEH2, Harms AC4, van der Stelt M5, Hankemeier T4, Jazet IM2,3, Boon MR2,3, Rensen PCN2,3. Author information Abstract South Asians have a higher risk to develop obesity and related disorders compared to white Caucasians. This is likely in part due to […]