Neurosci Biobehav Rev. 2017 May 30. pii: S0149-7634(17)30088-X. doi: 10.1016/j.neubiorev.2017.05.022.
[Epub ahead of print]
de la Tremblaye PB1, O’Neil DA1, LaPorte MJ1, Cheng JP1, Beitchman JA2, Thomas TC3, Bondi CO4, Kline AE5.
Abstract
The aim of this review is to discuss the research presented in a symposium entitled “Current progress in characterizing therapeutic strategies and challenges in experimental CNS injury” which was presented at the 2016 International Behavioral Neuroscience Society annual meeting. Herein we discuss diffuse and focal traumatic brain injury (TBI) and ensuing chronic behavioral deficits as well as potential rehabilitative approaches. We also discuss the effects of stress on executive function after TBI as well as the response of the endocrine system and regulatory feedback mechanisms. The role of the endocannabinoids after CNS injury is also discussed. Finally, we conclude with a discussion of antipsychotic and antiepileptic drugs, which are provided to control TBI-induced agitation and seizures, respectively. The review consists predominantly of published data.
Copyright © 2017 Elsevier Ltd. All rights reserved.
KEYWORDS:
Morris water maze (MWM); antiepileptic drugs (AEDs); antipsychotic drugs (APDs); controlled cortical impact (CCI); endocannabinoids; executive function; fluid percussion (FP) injury; rehabilitation; stress; traumatic brain injury
- PMID: 28576511
- DOI: 10.1016/j.neubiorev.2017.05.022
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