Archive | November, 2018
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Hemp (Cannabis sativa L.) Seed Phenylpropionamides Composition and Effects on Memory Dysfunction and Biomarkers of Neuroinflammation Induced by Lipopolysaccharide in Mice.

ACS Omega. 2018 Nov 30;3(11):15988-15995. doi: 10.1021/acsomega.8b02250. Epub 2018 Nov 27. Zhou Y1, Wang S1, Ji J1, Lou H1, Fan P1. Author information Abstract Hempseed has achieved a growing popularity in human nutrition, particularly regarding essential amino acids and fatty acids. The multiple positive attributes of hempseed have led to the further study of its […]

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Stilbenoids and cannabinoids from the leaves of Cannabis sativa f. sativa with potential reverse cholesterol transport activity.

Food Funct. 2018 Nov 30. doi: 10.1039/c8fo01896k. [Epub ahead of print] Guo T1, Liu Q1, Hou P2, Li F2, Guo S2, Song W2, Zhang H3, Liu X3, Zhang S3, Zhang J4, Ho CT5, Bai N1. Author information Abstract Three new stilbenoids (1-3) and 16 known stilbenoids (4-6) and cannabinoids (7-19) were isolated from the leaves […]

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Cannabinoid receptor type-1 partially mediates metabolic endotoxemia-induced inflammation and insulin resistance.

Physiol Behav. 2018 Nov 29;199:282-291. doi: 10.1016/j.physbeh.2018.11.035. [Epub ahead of print] Grunewald ZI1, Lee S2, Kirkland R3, Ross M4, de La Serre CB5. Author information Abstract Circulating levels of bacterial lipopolysaccharide (LPS) or endotoxin are chronically elevated in obesity (metabolic endotoxemia), resulting in low-grade inflammation. Metabolic endotoxemia has been identified as a triggering factor for […]

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Autism Spectrum Disorder and Cannabidiol: Have We Seen This Movie Before?

Carlos A. Salgado MD, Daniel Castellanos, MD First Published November 29, 2018 Article Commentary https://doi.org/10.1177/2333794X18815412 Article information    Recently, the use of marijuana and cannabidiol (CBD) in children with autism spectrum disorder (ASD) has received increasing attention in the media with articles sensationally titled “Marijuana may be a miracle treatment for children with autism.”1,2 An […]

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States Move to Substitute Opioids With Medical Marijuana to Quell Epidemic.

New Online Views 4,747 Citations 0 33 Medical News & Perspectives November 28, 2018 States Move to Substitute Opioids With Medical Marijuana to Quell Epidemic Rebecca Voelker, MSJ Article Information JAMA. Published online November 28, 2018. doi:10.1001/jama.2018.17329 As state governments grapple with ways to curb the opioid epidemic in their own backyard, New York and Illinois took a […]

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Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis.

Front Cell Neurosci. 2018 Nov 28;12:441. doi: 10.3389/fncel.2018.00441. eCollection 2018. Ferreira FF1,2, Ribeiro FF1,2, Rodrigues RS1,2, Sebastião AM1,2, Xapelli S1,2. Author information Abstract The adult mammalian brain can produce new neurons in a process called adult neurogenesis, which occurs mainly in the subventricular zone (SVZ) and in the hippocampal dentate gyrus (DG). Brain-derived neurotrophic factor […]

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Emerging drugs for the treatment of Dravet syndrome.

Expert Opin Emerg Drugs. 2018 Nov 27. doi: 10.1080/14728214.2018.1552937. [Epub ahead of print] Brigo F1,2, Striano P3, Balagura G3, Belcastro V4. Author information Abstract Dravet syndrome (DS) is an early-onset genetic developmental epileptic encephalopathy characterized by multiple seizure types which are refractory to antiseizure medication. There is an unmet need for effective and tolerable drugs […]

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Can Your DNA Influence Your Bet-Placing? The Impact of Cannabinoid Receptor 1 Gene on Gambling Tasks.

Front Hum Neurosci. 2018 Nov 27;12:458. doi: 10.3389/fnhum.2018.00458. eCollection 2018. Qin H1, Zeng J1, Chen H1, Deng L2, Su L1,3. Author information Abstract Are we placing a bet by ourselves or has our DNA already made the decision for us? Previous research has suggested that some genes related to dopamine or serotonin can influence our […]

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Cannabinoids, Chemical Senses, and Regulation of Feeding Behavior. Tarragon E1,2, Moreno JJ3,4.

Chem Senses. 2018 Nov 27. doi: 10.1093/chemse/bjy068. [Epub ahead of print] Tarragon E1,2, Moreno JJ3,4. Author information Abstract The herb Cannabis sativa has been traditionally used in many cultures and all over the world for thousands of years as medicine and recreation. However, because it was brought to the Western world in the late 19th […]

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A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans.

Front Pharmacol. 2018 Nov 26;9:1365. doi: 10.3389/fphar.2018.01365. eCollection 2018. Millar SA1, Stone NL1, Yates AS2, O’Sullivan SE1. Author information Abstract Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review […]