The interplay between inflammatory cytokines and the endocannabinoid system in the regulation of synaptic transmission.
Abstract
Copyright © 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
CB1 receptor; GABA; Glutamate; IL-1β; Multiple sclerosis; TNF; TRPV1
- PMID:
- 25268960
- [PubMed – as supplied by publisher]
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Highlights
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IL-1β regulates the synaptic effects of CB1 receptors.
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CB1 receptors regulate TNF-mediated potentiation of excitatory synaptic transmission.
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TRPV1 channels have a permissive role in the synaptic effects of IL-1β.
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Interplay between ECS and inflammatory cytokines controls behavior.
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ECS regulates neurodegenerative processes in multiple sclerosis.
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