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Canna~Fangled Abstracts

(±)-Sativamides A and B, Two Pairs of Racemic Nor-lignanamide Enantiomers from the Fruits of Cannabis sativa (Hemp Seed).

By January 18, 2018No Comments
J Org Chem. 2018 Jan 18. doi: 10.1021/acs.joc.7b02765.
[Epub ahead of print]

Abstract

PM 2 site 207(±)-Sativamides A (1) and B (2), two pairs of nor-lignanamide enantiomers featuring a unique benzo-angular triquinane skeleton, were isolated from the fruits of Cannabis sativa (hemp seed). Their structures were elucidated by detailed spectroscopic analysis and ECD calculations. The resolution of (+)- and (-)-sativamides A and B were achieved by chiral HPLC. Pretreatment of neuroblastoma cells with 1 and 2 significantly reduced the endoplasmic reticulum (ER) stress-induced cytotoxicity.
PMID: 29345463

 

DOI: 10.1021/acs.joc.7b02765
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